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Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 6 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (14 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (25 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (16 studies), Obesity (17 studies), Pregnancy (25 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (39 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

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Items found: 452
Title Modified
Different Vitamin D Receptor problems cause different COVID problems - Dec 2021 18 Dec, 2021
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
COVID, influenza, hepatitis B, measles, etc. vaccine responses vary with Vitamin D and its receptor 08 Dec, 2021
Gout 1.5 X more likely if a poor Vitamin D Receptor – 2014 04 Nov, 2021
Cancers and Vitamin D Receptors, including change with race – Feb 2021 24 Oct, 2021
Needing a high level of vitamin D is a good clue that the Vitamin D Receptor is deactivated 18 Oct, 2021
Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies 18 Oct, 2021
Poor Vitamin D receptor blocked Vitamin D from fighting avian influenza viruses (in mice) – July 2021 17 Oct, 2021
Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010 17 Oct, 2021
COVID-19 symptoms and comorbidities associated with the type of Vitamin D Receptor – Oct 2021 09 Oct, 2021
Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020 09 Oct, 2021
Little Vitamin D benefit if poor Vitamin D Receptor (400 studies annually) - Oct 2021 05 Oct, 2021
Enveloped virus infection (RSV, coronavirus, HIV, etc.) 1.5X more likely if poor Vitamin D Receptor – meta-analysis Dec 2018 02 Oct, 2021
PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021 23 Sep, 2021
Skin scars (Keloids) more likely if low vitamin D, poor Vitamin D receptor, or dark skin – Aug 2021 13 Sep, 2021
Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021 16 Aug, 2021
The vitamin d receptor and T cell function- June 2013 05 Aug, 2021
Atopies (allergy, asthma, rhinitis, etc.) variously associated with low Vitamin D and poor Vitamin D Receptor – Aug 2021 04 Aug, 2021
T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021 08 Jul, 2021
Male Infertility is associated with poor Vitamin D Receptor – July 2021 04 Jul, 2021
Poor male fertility is association with poor Vitamin D Receptor (less D to the cells) – July 2021 02 Jul, 2021
Poor response to Asthma inhaler if poor Vitamin D Receptor – Dec 2019 01 Jul, 2021
2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021 25 Jun, 2021
Graves' disease 2X more likely if poor Vitamin D Receptor (like many other autoimmune diseases) – May 2021 03 Jun, 2021
Quercetin (a flavonoid) helps activate the Vitamin D receptor – many studies 24 May, 2021
Vitamin D Receptor activation should reduce ARDS associated with COVID-19 - June 2020 23 May, 2021
Cytomegalovirus downregulates Vitamin D receptor, but tissues respond by increasing production – Sept 2016 19 May, 2021
Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021 26 Apr, 2021
Vitamin D may also get into cells via TRPV1 (not just VDR) – April 2021 08 Apr, 2021
Spondyloarthritis 5X more likely if poor Vitamin D Receptor – Dec 2020 10 Mar, 2021
Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019 26 Feb, 2021
Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020 17 Feb, 2021
Poor hip joint in infants associated with poor Vitamin D receptor – Jan 2021 31 Jan, 2021
Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021 15 Jan, 2021
Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020 31 Dec, 2020
Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020 09 Dec, 2020
Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021 07 Dec, 2020
Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020 03 Dec, 2020
Osteoporosis Risk varies with Vitamin D Receptor – three meta-analyses in 2020 25 Nov, 2020
Vitamin D Receptor is associated in over 58 autoimmune studies 12 Nov, 2020
Uterine Fibroids (uterine leiomyoma, need hysterectomy) 1.9 more likely if a Vitamin D receptor problem – Sept 2015 28 Oct, 2020
Risk of Major Depressive Disorder increased 2.2 X by a poor Vitamin D receptor – Oct 2020 10 Oct, 2020
Glaucoma 3.1 X more likely if a poor Vitamin D Receptor – Sept 2020 03 Oct, 2020
Spinal disc degeneration 1.8X more likely if poor Vitamin D Receptor – mata-analysis Sept 2020 17 Sep, 2020
Metabolic Syndrome risk increases about 20 percent if poor Vitamin D Receptor – Aug 2020 10 Aug, 2020
UVB phototherapy (which increases Vitamin D and VDR) decreased risk of many heart and stroke problems – July 2020 29 Jul, 2020
Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020 23 Jul, 2020
Respiratory problems in Children 1.4X more likely if poor Vitamin D receptor – April 2020 22 Jul, 2020
Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020 04 Jul, 2020
4X less of one chemo needed after vitamin D receptor activation - June 2020 02 Jun, 2020
Dengue virus 2X to 4X more likely if vitamin D receptor gene problems 08 May, 2020
Colorectal Cancer Patients 2.4 X more likely to have poor Vitamin D receptors (less D to cells) – April 2020 02 May, 2020
Crohn’s Disease is associated with poor Vitamin D Receptor (many solutions) – April 2020 29 Apr, 2020
3X reduction in Chemotherapy dose by Photodynamic Priming of Vitamin D Receptor (mice) – March 2020 30 Mar, 2020
Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018 10 Mar, 2020
Multiple Sclerosis 2X-3X more likely if poor Vitamin D Receptor – Meta-analysis Feb 2020 26 Feb, 2020
Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020 22 Feb, 2020
Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020 31 Jan, 2020
Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020 30 Jan, 2020
Parkinson’s disease 1.6X more likely if a poor Vitamin D Receptor – meta-analysis Jan 2020 28 Jan, 2020
Colorectal cancer linked to poor Vitamin D Receptor (yet again) – Jan 2020 22 Jan, 2020
Strong interactions between Vitamin D and the gut microbiota via Butyrate and VDR – Dec 2019 08 Jan, 2020
Autism 2X more likely if poor Vitamin D Receptor (yet again) – meta-analysis Jan 2020 05 Jan, 2020
Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019 31 Dec, 2019
Risk of Multiple Sclerosis varies with the Vitamin D Receptor – meta-analysis Dec 2019 26 Dec, 2019
Depression associated with poor Vitamin D Receptor (in mice) – Dec 2019 24 Dec, 2019
1.8 X more likely to have additional Dental Implant Failure if poor Vitamin D Receptor – Dec 2019 18 Dec, 2019
Autoimmune disease treated by Vitamin D, Zinc (and other activators of Vitamin D Receptor) – Oct 2019 17 Dec, 2019
Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 14 Dec, 2019
Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019 13 Dec, 2019
Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019 09 Dec, 2019
Parkinson’s disease 20 percent more likely in Asians if poor Vitamin D Receptor – meta-analysis April 2019 22 Nov, 2019
Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015 18 Nov, 2019
Vitamin D Receptor in gut can be activated by lithocholic acid produced by gut bacteria 16 Nov, 2019
Microbiomes of both gut and airway are affected by Vitamin D and Vitamin D Receptor – Nov 2018 16 Nov, 2019
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 15 Nov, 2019
Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017 12 Nov, 2019
Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015 12 Nov, 2019
Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 09 Nov, 2019
Cancer is leading cause of death - Vitamin D and Receptor activators help 09 Nov, 2019
Asthma 3.7X higher risk of poor Vitamin D Receptor (teens in Taiwan in this case) – Nov 2019 07 Nov, 2019
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 06 Nov, 2019
Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019 05 Nov, 2019
Increased risk of Osteoporosis if poor Vitamin D Receptor (UK males this time) – Sept 2019 01 Nov, 2019
Multiple Sclerosis much more likely if poor Vitamin D Receptor – several studies 31 Oct, 2019
Vitamin D Receptor summary 30 Oct, 2019
Liver Cirrhosis death is 4X more likely if poor Vitamin D Receptor – Sept 2018 29 Oct, 2019
Asthma is 20 percent more likely with a poor Vitamin D Receptor gene – meta-analysis Oct 2019 23 Oct, 2019
Temporary hair loss (Telogen Effluvium) is 15X more likely if poor Vitamin D Receptor – Oct 2019 22 Oct, 2019
Melatonin appears to also use the Vitamin D Receptor – Oct 2019 22 Oct, 2019
Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019 19 Oct, 2019
Hand, foot, and Mouth disease is 14X more likely if poor Vitamin D Receptor – Oct 2019 06 Oct, 2019
Lupus associated with both low vitamin D and Vitamin D receptor problems – April 2016 05 Oct, 2019
Non-alcoholic fatty liver disease and the Vitamin D Receptor – editorial Sept 2019 29 Sep, 2019
Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019 17 Sep, 2019
Leprosy risk is reduced by 3X for some types of Vitamin D Receptor (Brazil) – Sept 2019 13 Sep, 2019
Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018 10 Sep, 2019
Osteoporosis 3X higher risk of in white men having a poor Vitamin D receptor – Aug 2019 27 Aug, 2019
Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018 24 Aug, 2019
Osteoporosis is associated with genes such as the Vitamin D Receptor – July 2019 22 Aug, 2019
Created by admin. Last Modification: Monday October 3, 2022 16:22:58 GMT-0000 by admin. (Version 7)
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022        
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