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Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022

Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review

Nutrients 2022, 14(17), 3519; https://doi.org/10.3390/nu14173519
by Alessio Danilo Inchingolo et all

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. The review aims to investigate the effects of these molecules on bone metabolism and their role in several diseases such as osteopenia and osteoporosis, bone tumours, and periodontitis. The PubMed/Medline, Web of Science, Google Scholar, Scopus, Cochrane Library, and Embase electronic databases were searched for papers in line with the study topic. According to an English language restriction, the screening period was from January 2012 to 3 July 2022, with the following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” AND “bone”); (“quercetin” AND “bone”). A total of 36 papers were identified as relevant to the purpose of our investigation. The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis. Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration. According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies. The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
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VitaminDWiki - 6 studies in both categories VDR and Bone

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (14 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (25 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (16 studies), Obesity (17 studies), Pregnancy (25 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (39 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

VitaminDWiki pages with Vitamin D Receptor or VDR in title (400 as of Oct 2022)

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Items found: 452
Title Modified
Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014 23 Sep, 2016
Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016 22 Jul, 2016
Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analysis March 2013 22 Jul, 2016
Dengue Fever associated with poor vitamin D receptor – July 2002 01 May, 2016
Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016 24 Mar, 2016
Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 17 Mar, 2016
Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015 06 Jan, 2016
COPD strongly associated with Vitamin D receptor problems – meta-analysis Aug 2015 01 Dec, 2015
Growth Hormone problem (Acromegaly) 50 percent more likely if vitamin D receptor problem – March 2015 07 Nov, 2015
Vitamin D Receptors can be activated by other than Vitamin D - March 2015 18 Oct, 2015
Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015 18 Oct, 2015
Resistance exercise increases Vitamin D receptor for a few hours (in rats) – Oct 2015 17 Oct, 2015
Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015 13 Oct, 2015
Vitamin D Receptor can be modulated with a new compound – Feb 2014 01 Oct, 2015
Different response by Vitamin D Receptor to Vitamin D vs Vit. D analogs – Sept 2015 24 Sep, 2015
Vitamin D Receptor and immune differences between mice and men – Sept 2015 16 Sep, 2015
Vitamin D receptor genes vary a lot between races – Dec 2015 16 Sep, 2015
Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012 10 Sep, 2015
2.8X higher risk of osteoporosis if COPD and modified vitamin D receptor genes – Sept 2015 09 Sep, 2015
2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015 09 Sep, 2015
Vitamin D receptor functionality improved with probiotics – Sept 2015 02 Sep, 2015
Hypothesis Vitamin D receptor controls PTH without needing Vitamin D – Aug 2015 01 Sep, 2015
Poorly functioning Vitamin D Receptor (VDR) was 5X more likely in children with low vitamin D levels – July 2012 09 Aug, 2015
Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014 04 Aug, 2015
Vitamin D Receptors are important for health (technical)– May 2015 04 Aug, 2015
Genes in the blood are not static, 20 percent change with the seasons - such as Vitamin D Receptor – May 2015 13 May, 2015
Leprosy associated with changes to Vitamin D receptor genes (VDR)– April 2015 19 Apr, 2015
Health outcomes of vitamin D. Parts I (VDR) and II – 2014 23 Jan, 2015
Diseases, Vitamin D Receptor and other genes – June 2014 13 Jan, 2015
Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014 29 Dec, 2014
Ischemic stroke 2X more likely if Vitamin D Receptor gene problem – Dec 2014 17 Dec, 2014
Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 26 Nov, 2014
Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014 13 Jul, 2014
Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014 28 May, 2014
T1DM, toll-like receptors and vitamin D in rats – May 2014 21 May, 2014
Vitamin D receptor activation and Chronic Kidney Disease – Oct 2011 14 May, 2014
Subsequent melanomas associated with BsmI gene variation of VDR– May 2011 22 Mar, 2014
Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014 19 Mar, 2014
Vitamin D Receptor technical details – Jan 2010 11 Jan, 2014
The Overlooked Importance of VITAMIN D RECEPTORS - LEF Aug 2013 08 Jan, 2014
Free vitamin D (VDR) may be more important than total for bladder cancer – March 2013 06 Jan, 2014
Osteoporos 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013 31 Aug, 2013
Overlooked Importance of Vitamin D Receptors – Life Extension Mag. Aug 2013 21 Jul, 2013
Genes breast cancer and vitamin D receptor - Sept 2010 08 Jul, 2013
Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012 08 Jul, 2013
County with 20 pcnt higher breast cancer rate has 2X more modified vitamin D receptor – July 2012 08 Jul, 2013
Vitamin D receptor in breasts and breast cancer vary with race – March 2013 08 Jul, 2013
Hypothesis – Receptor activation more important than vitamin D levels – June 2011 12 May, 2013
Potential for vitamin D receptor agonists in the treatment of cardiovascular disease 03 Aug, 2011
Vitamin D receptors and breathing problems -April 2010 13 May, 2010
Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019 No value for 'modification_date_major'
Kidney failure 1.1 X more likely if poor Vitamin D Receptor – meta-analysis Dec 2019 No value for 'modification_date_major'
Created by admin. Last Modification: Monday October 3, 2022 16:22:58 GMT-0000 by admin. (Version 7)
Vitamin D Receptor activators (Resveratrol, Curcumin ,Quercetin) all improve bone – Review Aug 2022        
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