Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.
J Nutr. 2019 Apr 5. pii: nxz041. doi: 10.1093/jn/nxz041.
Mao C1, Li FR1, Yin ZX2, Lv YB3, Luo JS4, Yuan JQ1, Mhungu F1, Wang JN3, Shi WY3, Zhou JH3, Chen GC5, Gao X6, Kraus VB7, Wu XB1, Shi XM3.
1100 deaths
Mortality starts with:
People die sooner if they have low vitamin D
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- More vitamin D means fewer deaths – many studies
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Taking vitamin D extends life - 56 trials with 100,000 people - Dr. Greger video July 2016
- Much more likely to live longer if higher vitamin D – 27,000 seniors Feb 2017
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- 4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
- Senior women having low vitamin D were 2X more likely to die - Sept 2023
- Risk of death after bone fracture was 6.6 X higher if less than 10 ng of vitamin D – June 2017
See also VitaminDWiki
- You will live longer if you have a high level of vitamin D – March 2019
- Live longer if have more than 40 ng of Vitamin D (gene analysis of 10,500 people) – Jan 2019
- Top 10 causes of death - low vitamin D is associated with every cause - Nov 2018
- Chance of dying in hospital cut in half by just 10 ng higher level of Vitamin D – April 2016
Download the PDF from VitaminDWiki
BACKGROUND: High concentrations of plasma 25-hydroxyvitamin D [25(OH)D], a marker of circulating vitamin D, have been associated with a lower risk of mortality in epidemiologic studies of multiple populations, but the association for Chinese adults aged ≥80 y (oldest old) remains unclear.
OBJECTIVE: We investigated the association between plasma [25(OH)D] concentration and all-cause mortality among Chinese adults aged ≥80 y.
DESIGN:
The present study is a prospective cohort study of 2185 Chinese older adults (median age: 93 y). Prospective all-cause mortality data were analyzed for survival in relation to plasma 25(OH)D using Cox proportional hazards regression models, with adjustments for potential sociodemographic and lifestyle confounders and biomarkers. The associations were measured with HR and 95% CIs.
RESULTS:
The median plasma 25(OH)D concentration was 34.4 nmol/L at baseline. Over the 5466 person-year follow-up period, 1100 deaths were identified. Men and women were analyzed together as no effect modification by sex was found. After adjusting for multiple potential confounders, the risk of all-cause mortality decreased as the plasma 25(OH)D concentration increased (P-trend <0.01). Compared with the lowest age-specific quartile of plasma 25(OH)D, the adjusted HRs for mortality for the second, third, and fourth age-specific quartiles were 0.72 (95% CI: 0.57, 0.90), 0.73 (95% CI: 0.58, 0.93), and 0.61 (95% CI: 0.47, 0.81), respectively. The observed associations were broadly consistent across age and other subgroups. Sensitivity analyses generated similar results after excluding participants who died within 2 y of follow-up or after further adjustment for ethnicity and chronic diseases.
CONCLUSIONS:
A higher plasma 25-hydroxyvitamin D concentration was associated with a reduced risk of all-cause mortality among Chinese adults aged ≥80 y. This observed inverse association warrants further investigation in randomized controlled trials testing vitamin D supplementation in this age group.
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