Vitamin D Deficiency at 16-20 Weeks Gestation Is Associated with Impaired Lung Function and Asthma at 6 Years of Age.
Ann Am Thorac Soc. 2014 Mar 6.
Zosky GR 1, Hart PH, Whitehouse AJ, Kusel MM, Ang W, Foong RE, Chen L, Holt PG, Sly PD, Hall GL.
1University of Tasmania, School of Medicine, Hobart, Tasmania, Australia, University of Western Australia, Telethon Institute for Child Health Research, Subiaco, Australia ; Graeme.Zosky at utas.edu.au.
Rationale: Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal vitamin D deficiency during the early stages of lung development and post-natal lung function in human populations.
Objectives: To assess the association between maternal vitamin D deficiency, post-natal lung function and asthmatic status in a longitudinal birth cohort.
Methods: Serum was collected at 16-20 weeks gestation at the time of recruitment in a community based prospective birth cohort for measurement of vitamin D (25(OH)D). Lung function was assessed by spirometry according to ATS guidelines in children at 6 and 14 years of age. Demographic and clinical history data were collected by questionnaire at recruitment and at the follow up visits.
Measurements and Main Results: FVC Z-scores in both sexes (β; 0.007[0.001, 0.013], p = 0.02) and FEV1 Z-scores in females (β; 0.007[0.001, 0.013], p = 0.02) were positively associated with maternal serum 25(OH)D at 6 years of age. These associations were mostly absent at 14 years of age. Maternal vitamin D deficiency was positively associated with asthma at 6 years of age but only in males (OR; 3.03(1.02-9.02), p = 0.04).
Conclusions: This study supports the notion that vitamin D deficiency during lung development may impact on post-natal lung growth and increase the risk of developing lung disease.
PMID: 24601713
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Pages listed in BOTH of the categories BREATHING and PREGNANCY
- 40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3% – May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Resulting childhood Asthma cut in half if 4,400 IU Vitamin D daily while pregnant - RCT April 2023
- Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
- Small vitamin D doses given during pregnancy do not reduce childhood asthma – meta-analysis Dec 2020
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Childhood Asthma risk greatly reduced if mothers were given 4,400 IU Vitamin D daily – RCT 2019
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Asthma 7 percent less likely for every 40 IU increase in (early) maternal diet – Feb 2018
- Pregnant women with low vitamin D (e.g. asthmatics) were more likely to have infants with vitamin D problems (asthmatics) – Jan 2018
- Lots of sugar while pregnant doubles asthma risk – 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017
- Birth asphyxia 2.4 times more likely if mother was vitamin D deficient – 2016
- Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016
- Vitamin D during pregnancy reduces risk of childhood asthma by 13 percent – meta-analysis Dec 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
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- Asthma in 3 year olds decreased somewhat with 4,000 IU during pregnancy – RCT Jan 2016
- Asthma trial underway - 4,000 IU during pregnancy - March 2014
- Infant wheezing 40 percent less likely if mother supplemented with vitamin D, vitamin E, or Zinc – meta-analysis Aug 2015
- Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015
- Wheezing reduced 35 percent if vitamin D added during pregnancy – April 2015
- Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015
- Low vitamin D during pregnancy associated with four health problems in children – Jan 2015
- Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013
- Single dose of 200,000 IU of vitamin D during pregnancy did not reduce wheezing 3 years later – June 2013
- Season of birth associated with Pneumonia (10 %) and Multiple Sclerosis (30 %) – May 2013
- Dial D for danger – absurd editorial in Thorax – Oct 2012
- High maternal vitamin D resulted in 30 percent less infant problems with breathing – Nov 2011
- Smoking while pregnant lowers vitamin D and increases child asthma by 3.6 X – Aug 2011
- 800 IU Vitamin D while pregnant decrease child asthma by 2X- Sept 2010
- Vitamin D Newsletter May 2010
- Winter babies are more prone to food allergies
Pages listed in BOTH of the categories BREATHING and INFANT/CHILD
- 3X reduction in respiratory infections in children taking more than 800 IU of Vitamin D weekly – Nov 2024
- Risk of childhood pneumonia reduced 30% by high Vitamin D - Oct 2024
- Bronchopulmonary dysplasia, in a third of preemies, 87% reduced risk for just 1 ng higher Vitamin D level – Oct 2024
- Infant respiratory distress reduced by Vitamin D – meta-analysis July 2024
- Vitamin D levels are low during Recurrent Wheezing - Feb 2024
- Obese asthmatic children Vitamin D - 50,000 IU then 8,000 IU daily - RCT Jan 2024
- France has injected 200,000 infants with RSV vaccine, based on no long-term data - Here we go again - Dec 2023
- Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023
- Prevention of allergies, eczema, asthma, in children – Vitamin D during pregnancy is a principal solution – July 2023
- Respiratory infection, children and Vitamin D - many studies
- Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023
- 3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023
- Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023
- RSV kills 100,000 children annually around the world (Vitamin D can help)– May 2022
- Small doses of Vitamin D do not reduce childhood breathing allergies – meta-analysis Oct 2022
- Vitamin D reduces childhood allergic airway diseases (confirmed by metabolomics this time) – May 2022
- Wheezing and asthmatic children have weaker Vitamin D responses - May 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- Allergy medications may be improved by Vitamin D (6X for birch pollen in this case) – Aug 2021
- Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021
- Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021
- The 6 percent of infants hospitalized for ARI are 2.2 X more likely to be Vitamin D deficient – April 2021
- Acute pneumonia in children 3X less likely if greater than 30 ng of vitamin D – Jan 2021
- Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020
- Recurrent Wheezing in children is associated with low Vitamin D – several studies
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Gene which predicts wheezing is associated with low vitamin D – Oct 2019
- Bronchiolitis in children associated with both pollution and low solar – July 2019
- Allergic Rhinitis in infants treated by 1,000 IU vitamin D daily – June 2019
- Asthmatic children 5X more likely to have a poor Vitamin D Receptor – June 2019
- Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
- Childhood Asthma somewhat reduced by 2400 IU vitamin D late in pregnancy (néed more, earlier) March 2019
- Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019
- Black infant recurrent wheezing rate dropped from 42 percent to 31 percent with just 400 IU of vitamin D – RCT Dec 2018
- Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
- Immature lungs in immature newborns – Vitamin D helps – Sept 2018
- Bronchiolitis had 1.3 X longer hospitalization if low Vitamin D (1016 infants) – Sept 2018
- Pneumonia in Egyptian Children 3.6 X more likely if poor Vitamin D Receptor – Aug 2018
- Childhood pneumonia not treated by 100,000 IU of vitamin D – Cochrane (need more, inhaled) – July 2018
- Pneumonia is increasing (now 1 in 6 child deaths), more vitamin D studies needed – June 2018
- Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Both parents smoke – child’s vitamin D level was 30 percent lower and worse asthma – May 2018
- Allergic rhinitis in children reduced somewhat during pollen season by just 1,000 IU of vitamin D – RCT Jan 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Rapid newborn breathing (transient tachypnea) associated with low vitamin D – Dec 2017
- Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017
- Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017
- Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017