Exploring the association between magnesium deficiency and chronic obstructive pulmonary diseases in NHANES 2005–2018
Yixin Zhao, Hongwei Li, Zhenyu Wang, Yue Qi, Yu Chang, Yuguang Li, Dongsheng Xu & Xiao Chen
Scientific Reports volume 14, Article number: 25981 (2024) https://doi.org/10.1038/s41598-024-76374-1
Chronic Obstructive Pulmonary Disease (COPD) significantly impacts patients’ quality of life and burdens healthcare systems. Magnesium is crucial for lung function and reducing respiratory disease risk. This study investigates the association between Magnesium Depletion Score (MDS) and COPD and explores whether inflammatory markers mediate this relationship. A cross-sectional analysis was conducted using data from 30,490 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. MDS was calculated based on diuretic use, proton pump inhibitors, renal function, and alcohol consumption. Univariable and multivariable logistic regression analyses were performed to assess the association between MDS and COPD, adjusting for potential confounders. Mediation analysis was used to examine the roles of neutrophils, serum albumin, and the Systemic Immune-Inflammation Index (SII). In the univariable logistic model, higher MDS was significantly associated with increased COPD risk.
Specifically, compared to MDS = 0, the odds ratios (OR) for COPD were
- 2.50, 4.12, 6.13, 8.53, and 7.81 for MDS = 1, 2, 3, 4, and 5, respectively (all P < 0.001).
In the multivariable model, the ORs were 1.79, 2.25, 2.71, and 3.44 for MDS = 1, 2, 3, and 4, respectively (all P < 0.001). Higher neutrophil levels and SII were positively associated with increased COPD risk, while higher serum albumin levels were inversely associated. Mediation analysis indicated that neutrophils, serum albumin, and SII significantly mediated the MDS-COPD relationship. Higher MDS is significantly associated with increased COPD risk, mediated by systemic inflammation markers. Improving magnesium levels could potentially reduce COPD risk, warranting further research on magnesium supplementation in COPD prevention and management.
No such attachment on this page
VitaminDWiki – COPD fought by Vitamin D - many studies contains:
- Vitamin D is one of the alternate COPD therapies – March 2021
- COPD treated by Vitamin D – meta-analysis March 2022
- COPD quality of life improved by 400,000 IU Vitamin D loading dose – RCT July 2019
- COPD exacerbations 2X less often if low vitamin D then supplemented – meta-analysis Jan 2019
- Worse breathing with COPD is related to lower Vitamin D – June 2018
- COPD ICU stay is 2.4 days longer if low vitamin D – Oct 2015
- COPD and Vitamin D, concise (46 page) review – Dec 2016
- 100000 IU vitamin D monthly helps COPD patients – 3 RCT
- Those with Asthma or COPD had half the response to Vitamin D – March 2020
VitaminDWiki – Magnesium and Vitamin D contains
- Overview Magnesium and vitamin D
- Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
- The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
- Magnesium deficiency – causes and symptoms – May 2016
- Magnesium Depletion Score predicts increased risk of various health problems
- Vitamins and Metals needed by the Immune System – Jan 2020
- Magnesium: intake decreased, difficult to measure in body – Sept 2018
- Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
- Magnesium is important for health but levels are low – July 2018
- How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
- Magnesium etc. reduced in crops (must supplement) – 2009
Mg and Vitamin D
- Intracellular Magnesium and Vitamin D - a few studies
- Vitamin D and Magnesium need each other - many studies
- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
- 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
- Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
- Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
- Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
- Vitamin D Cofactors in a nutshell
- Magnesium and Vitamin D - similar, different and synergistic
Magnesium topics gathered on a page
- Vitamin D, Omega-3, and Magnesium are synergistic - many studies
- Magnesium and Cancer - many studies
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Low Magnesium associated with severe COVID – many studies
- Calcium to Magnesium Ratio - many studies
- Magnesium Role in Health and Longevity - many studies
- Magnesium reduces pain - many studies
- Vitamin D and Magnesium need each other - many studies
- Pregnancy helped by Magnesium - many studies
VitaminDWiki – Overview Magnesium and vitamin D has a venn diagram
| Magnesium | not Magnesium | |
| Vitamin D | Magnesium or Vitamin D Aging, Amyotrophic Lateral Sclerosis, Alzheimer's Disease; Asthma, Attention Deficit Disorder, Autism, Cancer, Cerebrovascular, Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis, Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones, Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis, Peripheral vascular disease; Pregnancy-related problems, Rheumatoid Arthritis, Sports-related problems, | Vitamin D only Acne, Allergy, Autoimmune, Bone, Breathing, Celiac, Cognition, Colds and Flu, Cystic Fibrosis, Dental, Fertility, hyperparathyroid, Immunity, Kidney, Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson, Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid, Tuberculosis, Vision, Hair, Skin, Sports |
| Not Vitamin D | Magnesium only Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy, Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation, Cramps, Fluoride Toxicity, Head Injuries, Central Nervous System Injuries, Magnesium Deficiency; Menopause, Mitral Valve Prolapse, Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS, Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence | Neither ALL OTHER DISEASES |
| 250 visitors, last modified 01 Nov, 2024, |