Front Pharmacol, 2020 Dec 17;11:604579. doi: 10.3389/fphar.2020.604579
Mohamed Said Boulkrane1, Victoria Hina1, Roman Melchakov1, Julia Fedotova2,3 julia.fedotova at mail.ru, Filippo Drago4, Lucia Gozzo4, Undurti Narasimha Das5, A. M. Abd El-Aty6,7 and Denis Baranenko1
1 1nternational Research Centre “Biotechnologies of the Third Millennium”，ITMO University, Saint-Petersburg, Russia,
2 Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia,
3 Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia,
4 Department of Biomedical and Biotechnological Sciences, Biological Tower, School of Medicine, University of Catania, Catania, Italy,
5 UND Life Sciences, Battle Ground, WA, United States,
6 Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt,
7 Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum, Turkey
Novel coronavirus disease (COVID-19) pandemic caused by SARS-CoV-2, for which there is no effective treatment except employing prevention strategies, has already instituted significant number of deaths. In this review, we provide a scientific view on the potential role of vitamin D in SARS-CoV-2 virus/COVID-19 disease. Vitamin D is well-known to play a significant role in maintaining the immune health of an individual. Moreover, it induces antimicrobial peptide expression that can decrease viral replication and regulate the levels of pro-inflammatory/anti-inflammatory cytokines. Therefore, supplementation ofvitamin D has the potential to reduce the incidence, severity and the risk of death from pneumonia resulting from the cytokine storm of many viral infections including COVID-19. We suggest that supplementation of subjects at high risk of COVID-19 with vitamin D (1.000 to 3.000 IU) to maintain its optimum serum concentrations may be of significant benefit for both in the prevention and treatment of the COVID-19.
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