Table of contents
- Efficacy and Safety of a Personalized Vitamin D3 Loading Dose Followed by Daily 2000 IU in Colorectal Cancer Patients with Vitamin D Insufficiency: Interim Analysis of a Randomized Controlled Trial
- VitaminDWiki - Cancer - Colon category contains
- Gut problems need gut-friendly forms of Vitamin D - see Overview Gut and vitamin D
Efficacy and Safety of a Personalized Vitamin D3 Loading Dose Followed by Daily 2000 IU in Colorectal Cancer Patients with Vitamin D Insufficiency: Interim Analysis of a Randomized Controlled Trial
Nutrients 2022, 14(21), 4546; https://doi.org/10.3390/nu14214546
by Sabine Kuznia et al
Note: need more than 40 ng of vitamin D to treat most cancers
A personalized vitamin D3 loading dose has not yet been tested in cancer patients. This interim analysis of the randomized, placebo-controlled VICTORIA trial analyzed the first recruited 74 German adults with nonmetastatic colorectal cancer, a tumor surgery within the past year, and 25-hydroxyvitamin D levels (25(OH)D) < 50 nmol/L. Study participants received a loading dose tailored for a baseline 25(OH)D level and BMI in the first 11 days, followed by a maintenance dose of 2000 IU of vitamin D3 daily until end of trial week 12. The mean 25(OH)D levels were 27.6, 31.0, and 34.1 nmol/L in the placebo group and 25.9, 63.1, and 75.5 nmol/L in the verum group during screening, visit 1 (end of loading dose), and visit 2 (end of maintenance dose), respectively. The prevalence of 25(OH)D) ≥ 50 nmol/L at visits 1 and 2 was 3.5% and 17.4% in the placebo group and 80.0% and 100% in the verum group. No events of 25(OH)D > 150 nmol/L or hypercalcemia were observed. Hypercalciuria events at visit 1 (n = 5 in verum and n = 1 in the placebo group; p = 0.209) receded after discontinuation of the study medication. The personalized loading dose effectively and safely increased the 25(OH)D levels, and 2000 IU of vitamin D3 daily sustained the achieved levels.
Download the PDF from VitaminDWiki
VitaminDWiki - Cancer - Colon category contains
- Cancer - Colon category listing has
147 items - 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
- 25+ Colon Cancer meta-analyses
- Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021
- Cancer - After diagnosis category listing has
117 items along with related searches - see also:
Overview Cancer-Colon and vitamin D. Overview Cancer and vitamin D Overview Gut and vitamin D Cancer and Vitamin D - many studies
Gut problems need gut-friendly forms of Vitamin D - see Overview Gut and vitamin D
Gut-friendly, Sublingual, injection, topical, UV, sunshineGetting Vitamin D into your blood and cells has the following chart
Getting Vitamin D into your blood and cells also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gutBio Form Speed Duration 10 Injection ($$$)
or Calcidiol or CalcitriolD - Slow
C -FastLong 10 Sun/UVB Slow Long 10 Topical
(skin patch/cream, vagina)Slow
Fast nanoNormal 9 Nanoemulsion -mucosal
perhaps activates VDRFast Normal 9? Inhaled (future) Fast Normal 8 Bio-D-Mulsion Forte Normal Normal 6 Water soluble (Bio-Tech) Normal Normal 4 Sublingual/spray
(some goes into gut)Fast Normal 3 Coconut oil based Slow Normal 2 Food (salmon etc.) Slow Normal 2 Olive oil based (majority) Slow Normal 10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 monthsColorectal Cancer – vitamin D did not help (too small of a response) – RCT Oct 2022(Cached) Printer Friendly Follow this page for updates7345 visitors, last modified 29 Oct, 2022, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 18745 Colorectal RCT.jpg admin 29 Oct, 2022 25.04 Kb 187 18744 Colon Cancer load then 2,000 IU daily_CompressPdf.pdf admin 29 Oct, 2022 488.89 Kb 206 - see also: