Hypomagnesemia in the Cancer Patient
Kidney360. 2021 Jan 28; 2(1): 154–166.. doi: 10.34067/KID.0005622020
Biruh T. Workeneh, 1 Nupur N. Uppal, 2 Kenar D. Jhaveri, 2 and Helbert Rondon-Berrioscorresponding author 3
Hypomagnesemia is a common medical problem that contributes to the morbidity and mortality of patients with cancer. This review summarizes magnesium physiology and highlights the mechanisms underlying magnesium disturbances due to cancer and cancer treatment. The causes of hypomagnesemia can be categorized according to the pathophysiologic mechanism: decreased intake, transcellular shift, gastrointestinal losses, and kidney losses. Patients with cancer are at risk for opportunistic infections, frequently experience cardiovascular complications, and often receive classes of medications that cause or exacerbate hypomagnesemia. Also, cancer-specific therapies are responsible for hypomagnesemia, including platinum-based chemotherapy, anti-EGF receptor mAbs, human EGF receptor-2 target inhibitors (HER2), and calcineurin inhibitors. Urinary indices, such as the fractional excretion of magnesium, can provide useful information about the etiology. The management of hypomagnesemia depends on the magnitude of hypomagnesemia and the underlying cause. We recommended checking serum magnesium at the beginning of treatment and as part of routine monitoring throughout cancer treatment. Opportunities exist for potential research and practice improvement, including further characterization of hypomagnesemia regarding the clinical effect on cancer outcomes, preventing hypomagnesemia in patients receiving high-risk anticancer agents, and developing effective therapeutic strategies.
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VitaminDWiki - Magnesium and Vitamin D contains
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Magnesium topics gathered on a page
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VitaminDWiki Magnesium pages with CANCER in title (11 as of June 2022)
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1479 visitors, last modified 09 Jun, 2022, |
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17800 | Cancer society grades.jpg | admin 09 Jun, 2022 | 33.43 Kb | 156 | |
17799 | Mg types.jpg | admin 09 Jun, 2022 | 170.85 Kb | 259 | |
17798 | Cancer drugs reduce Mg.jpg | admin 09 Jun, 2022 | 103.87 Kb | 206 | |
17797 | Reasons for hypoMg.jpg | admin 09 Jun, 2022 | 69.93 Kb | 182 | |
17796 | Hypomagnesemia in the Cancer Patient.pdf | admin 09 Jun, 2022 | 771.96 Kb | 159 |