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Low magnesium if poor kidney, poor gut, cancer, cancer drugs – Jan 2021


Hypomagnesemia in the Cancer Patient

Kidney360. 2021 Jan 28; 2(1): 154–166.. doi: 10.34067/KID.0005622020
Biruh T. Workeneh, 1 Nupur N. Uppal, 2 Kenar D. Jhaveri, 2 and Helbert Rondon-Berrioscorresponding author 3


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Hypomagnesemia is a common medical problem that contributes to the morbidity and mortality of patients with cancer. This review summarizes magnesium physiology and highlights the mechanisms underlying magnesium disturbances due to cancer and cancer treatment. The causes of hypomagnesemia can be categorized according to the pathophysiologic mechanism: decreased intake, transcellular shift, gastrointestinal losses, and kidney losses. Patients with cancer are at risk for opportunistic infections, frequently experience cardiovascular complications, and often receive classes of medications that cause or exacerbate hypomagnesemia. Also, cancer-specific therapies are responsible for hypomagnesemia, including platinum-based chemotherapy, anti-EGF receptor mAbs, human EGF receptor-2 target inhibitors (HER2), and calcineurin inhibitors. Urinary indices, such as the fractional excretion of magnesium, can provide useful information about the etiology. The management of hypomagnesemia depends on the magnitude of hypomagnesemia and the underlying cause. We recommended checking serum magnesium at the beginning of treatment and as part of routine monitoring throughout cancer treatment. Opportunities exist for potential research and practice improvement, including further characterization of hypomagnesemia regarding the clinical effect on cancer outcomes, preventing hypomagnesemia in patients receiving high-risk anticancer agents, and developing effective therapeutic strategies.
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Created by admin. Last Modification: Thursday June 9, 2022 22:35:40 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
17800 Cancer society grades.jpg admin 09 Jun, 2022 33.43 Kb 156
17799 Mg types.jpg admin 09 Jun, 2022 170.85 Kb 259
17798 Cancer drugs reduce Mg.jpg admin 09 Jun, 2022 103.87 Kb 206
17797 Reasons for hypoMg.jpg admin 09 Jun, 2022 69.93 Kb 182
17796 Hypomagnesemia in the Cancer Patient.pdf admin 09 Jun, 2022 771.96 Kb 159