Cutaneous Melanoma: Sheep in Wolves Clothing?
Anticancer Research 42: 5021-5025 (2022) doi:10.21873/anticanres.16010
FRANK R. DE GRUIJL1 and BRUCE K. ARMSTRONG2
1 dermatology, Leiden University Medical Center, Leiden, the Netherlands;
2 School of Global and Population Health, The University of Western Australia, Perth, WA, Australia
NOTE: Sunbeds are used infrequently
and have much higher raitio of UV/UVB than sunlight
Cutaneous melanoma incidence in European-origin populations has risen steeply, however, mortality has not, as 73 years of Danish cancer data strikingly show. It has been suggested that such divergent trends in the US are due to overdiagnosis from increasing diagnostic scrutiny and lowering diagnostic threshold. Alternatively, the increase in melanoma incidence may be largely due to increased sun exposure, which would imply that most of these new, sun-caused, melanomas are non-lethal. Consistent with this hypothesis, Icelandic data show an increase in melanoma incidence, predominantly in young women (<50 years), which paralleled increasing sunbed use that remitted after a campaign against sunbeds. Meanwhile, melanoma mortality in young people remained virtually zero. The increase in mortality was mainly in the elderly (>50 years) and dictated by year of birth. This transient excess of melanoma in young people is most likely attributable to skin burns from sunbeds which, like sunburns, carry a high risk of melanoma. High exposure ofnaevi to UV radiation can induce transient clinical and pathological features of melanoma, which might explain some of the apparent rise in incidence. Ways of distinguishing non-lethal from potentially lethal thin melanomas are sorely needed.
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People who get UVA daily rarely get melanoma
Vitamin D levels from daily UVB build up and prevent DNA damage from UVA
Outdoor workers, gardeners, native Americans, seafarers, etc,
VitaminDWiki pages with MELANOMA in title (42 as of Oct 2022)
This list is automatically updated
Items found: 46
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Modified |
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Melanoma risk reduced by Vitamin D and other nutrients - 2023 |
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27 Jun, 2024 |
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Melanoma death risk 0.63 X lower if poor Vitamin D Binding Gene – July 2023 |
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26 Aug, 2023 |
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Metastatic Melanoma survived 2X longer if adequate level of Vitamin D – July 2023 |
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03 Aug, 2023 |
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Melanoma is 1.4X more-likely if low Vitamin D – meta-analysis May 2023 |
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18 May, 2023 |
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Melanoma might be suppressed by Vitamin D - many studies |
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25 Nov, 2022 |
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Melanoma Cancer detected more often (perhaps due to infrequent intense UVA) – Oct 2022 |
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07 Oct, 2022 |
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Overview Suntan, melanoma and vitamin D |
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28 Nov, 2021 |
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Melanoma not treated by small doses of vitamin D (100,000 IU every 50 days) – RCT June 2021 |
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30 Jun, 2021 |
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Melanoma huge increase - perhaps due to use of sunscreen or lower vitamin D - Aug 2014 |
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26 Apr, 2021 |
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Melanoma associated with vitamin D less than 30 ng (9X) – March 2021 |
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13 Mar, 2021 |
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Recurrence of malignant melanoma may be reduced by 100,000 IU of vitamin D monthly – trial underway 2017 |
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13 Mar, 2021 |
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Melanoma 25 X more likely if low vitamin D – Feb 2018 |
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13 Mar, 2021 |
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Sunlight on skin has decreased 9X while melanoma has increased 30X – Feb 2020 |
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20 Feb, 2020 |
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Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 |
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11 Jan, 2020 |
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Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 |
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06 Nov, 2019 |
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Melanoma Is a Disease of Office Workers - Dec 2018 |
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12 Dec, 2018 |
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Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018 |
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20 Nov, 2018 |
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UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017 |
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09 Oct, 2017 |
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Non-melanoma skin cancer varies with latitude, melanoma does not – April 2017 |
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23 May, 2017 |
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Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016 |
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27 Jan, 2017 |
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People with metastatic melanoma and initially Vitamin D deficient had 4.7 times worse outcome if not get enough D – Dec 2016 |
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31 Dec, 2016 |
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Vitamin D being considered for Melanoma – active vitamin D is produced by skin – Nov 2016 |
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01 Dec, 2016 |
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Melanoma survival doubled with Vitamin D binding protein polymorphism – Nov 2015 |
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18 Nov, 2015 |
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Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014 |
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24 Oct, 2014 |
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Melanoma REDUCED by those getting the most UV, unless 5 blistering sunburns while in teen years – June 2014 |
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05 Jun, 2014 |
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Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014 |
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28 May, 2014 |
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Melanoma and Vitamin D genes - multiple papers |
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22 Mar, 2014 |
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Subsequent melanomas associated with BsmI gene variation of VDR– May 2011 |
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22 Mar, 2014 |
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Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014 |
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19 Mar, 2014 |
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Decreased risk of non-melanoma skin cancer by working outdoors in Europe – April 2013 |
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22 Dec, 2013 |
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UV and Melanoma: are they related – 2013 |
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19 Dec, 2013 |
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The Protective Role of Vitamin D Signaling in Non-Melanoma Skin Cancer - Nov 2013 |
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14 Dec, 2013 |
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Melanoma is 44 percent LESS LIKELY if get sun on the job – Nov 2013 |
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01 Dec, 2013 |
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Melanoma not as thick if recently had a sunny vacation – Nov 2013 |
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14 Nov, 2013 |
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UVA most likely causes melanoma to progress– Sept 2011 |
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10 Nov, 2013 |
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Prostate Cancer increased melanoma rate by 2X (vitamin D not mentioned) Nov 2013 |
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09 Nov, 2013 |
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Melanoma and Vitamin D - association is not certain - 2012 |
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14 Jul, 2013 |
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Melanoma reduces by half the amount of vitamin D activated by the skin – March 2013 |
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17 Apr, 2013 |
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Melanoma less likely when far from equator – Oct 2012 |
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07 Dec, 2012 |
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Red-haired mice can get melanoma without UV - Oct 2012 |
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29 Nov, 2012 |
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Hypothesis – worldwide increase in Melanoma due to UVA – Oct 2011 |
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17 Oct, 2012 |
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Sun exposure is associated with increased survival from melanoma – 2005 |
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07 Oct, 2012 |
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No association found between melanoma and low vitamin D levels – Sept 2012 |
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12 Sep, 2012 |
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UVB, Smoking and second cancers after melanoma – Jan 2012 |
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06 Mar, 2012 |
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Perhaps 28-40 ng of vitamin D would be good for Melanoma patients – Feb 2011 |
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06 Mar, 2011 |
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Study Suggests Indoor Tanning Boosts Chances of Melanoma |
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27 May, 2010 |