Dose-response relationship between serum 25-hydroxyvitamin D and the risk of metabolic syndrome
Clin Nutr. 2021 Mar 4;40(4):1530-1536. doi: 10.1016/j.clnu.2021.02.031
Shaojing Yu 1, Lulu Song 2, Qing Wei 1, Yongman Lv 3, Zhengce Wan 4
Metabolic Syndrome category has the following
See also
- Overview Metabolic Syndrome and vitamin D
- Overview Diabetes and vitamin D
- Overview Obesity and Vitamin D
- Diabetes, Metabolic Syndrome and Magnesium - many studies
- Arteries and Atherosclerosis and Vitamin D - many studies
- Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
- Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
- Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
- Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
- Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
- Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
- Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018
- Metabolic Syndromes fought by Vitamin D in 6 ways – Oct 2023
Metabolic Syndrome images from web (nothing about vitamin D)
Background & aims: There are conflicting results for the association of 25-hydroxyvitamin D [25(OH)D] with metabolic syndrome (MetS). The aim of this study was to investigate the relationship between serum 25(OH)D concentration and MetS and its components in a Chinese adult population.
Methods: A cross-sectional study of 25,691 men and 22,146 women from China was performed in 2017. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel Ш. Logistic and restricted cubic spline regression analyses were used to assess the association between 25(OH)D and MetS.
Results: Of the 43,837 participants aged 18-96 years, the prevalence of MetS was 21.0%. The adjusted odds ratios (ORs) for MetS decreased gradually with increasing 25(OH)D concentrations (P for trend < 0.001). Compared with the lowest 25(OH)D quartile, the adjusted ORs (95% CIs) for MetS from second to the highest quartile were 0.95 (0.88-1.02), 0.82 (0.76-0.88), and 0.70 (0.65-0.75), respectively. We observed a linear dose-response relationship between 25(OH)D concentrations and MetS risk (P for nonlinear trend = 0.35); the risk of MetS decreased by 20% (OR = 0.80, 95%CI: 0.77-0.82) for each 10 ng/ml increment in 25(OH)D concentration. The inverse association was more evident in men and participants with eGFR <60 ml/min/1.73 m2 or AST ≥40 U/L (all P for interaction < 0.05). Moreover, significant inverse relationships were observed between 25(OH)D and elevated triglycerides, reduced high-density lipoprotein cholesterol and elevated blood pressure.
Conclusions: These findings suggested that higher 25(OH)D concentrations were independently associated with a dose-response decreased risk of MetS among Chinese adults.
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