Obese get less benefit from vaccines: influenza, hepatitis B, rabies and now COVID-19 - March 2021

BMI, age, and gender affect COVID-19 vaccine antibody response MDEdge

based on preprint Feb 26 - seems like only 10% or less

VitaminDWiki observes that
1) Obese have lower levels of vitamin D
2) Lower levels of vitamin D are associated with poorer immune systems

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VitaminDWiki

• Virus (adeno-36) increases Obesity which then increases risk of another virus (Influenza) - Oct 2013

Overview Obesity and Vitamin D contains the following summary

• FACT: People who are obese have less vitamin D in their blood
• FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
• FACT: When obese people lose weight the vitamin D level in their blood increases
• FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
• FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
• FACT: Less weight gain by senior women with > 30 ng of vitamin D
• FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
• FACT: Obese lost 3X more weight by adding $10 of Vitamin D
• FACT: Those with darker skins were more likely to be obese Sept 2014
• OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
• OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
  • and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
• SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
• SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
    risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc.
• Obesity category has 442 items

See also: Weight loss and Vitamin D - many studies   Child Obesity and Vitamin D - many studies   Obesity, Virus, and Vitamin D - many studies
Obese need more Vitamin D

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

• Normal weight     Obese     (50 ng = 125 nanomole)

Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has the following
Fast weight loss by Obese Adults: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus

Flu has the following

Vitamin D fights all phases of Influenza

• FACT: Vitamin D PREVENTS Influenza 7X lower risk
• FACT: Vitamin D SUPRESSES Influenza ( Vitamin D Hammer )
  • Single dose of 50,000 IU of vitamin D stops Influenza symptoms
• FACT: Vitamin D PREVENTS & SUPRESSES Sepsis which is a rare but deadly consequence of Influenza
• FACT: Vitamin D enhances the activity of vaccines.
• FACT: improves Flu vaccine effectiveness and reduces side effects
• FACT: Vitamin D has virtually no side effects
  • but 1 in 300 get people get muscle pain or itching due to lower magnesium levels
• FACT: Vitamin D prevents/suppresses over 120 health problems (left column)
• FACT: Both COVID-19 and Influenza are enveloped viruses
  • Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011
• FACT: Do not take vitamin D if Sarcoidosis, excess Calcium, Chemotherapy
• CONCLUSION To help protect/suppress influenza, take 50,000 IU of Vitamin D once a week
     during the flu season if you are an average weight adult

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Web

• How obesity could create problems for a COVID vaccine Nature Oct 2020