Oral Vitamin D versus Injectable Vitamin D in Treating Obese Women with Vitamin D Deficiency
Egyptian Journal of Hospital Medicine, Volume 94, Issue 1, January 2024, Page 311-314 DOI: 10.21608/ejhm.2024.337170
Background: Vitamin D deficiency is a widespread problem especially in females. The presence of different vitamin D preparations (oral, parenteral) with no definite evidence about the most appropriate method for vitamin D deficiency treatment aroused the need for more studies about the most effective route.
Aim: To evaluate the oral vitamin D preparation compared to intramuscular (IM) vitamin D preparation in correcting vitamin D deficiency in affected women. Subjects and methods: This is an interventional research performed on obese female patients diagnosed with vitamin D deficiency in the 2019–2022 timeframe for outpatient clinics at Zagazig University Hospitals. Eighty females were included in the study. They were allocated randomly into 2 equal groups (40 females per group); oral group and injection groups, based on their preference. Pre and post intervention assessment was done by assessing the level of serum vitamin D.
Results: There was statistically insignificant difference among studied groups concerning vitamin D level before therapy, while there was significant difference between them after therapy, where oral group had significantly higher level. Within each group, there was significant increase in vitamin D level after therapy. There was statistically significant positive correlation between percent of increase in vitamin D and both age and body mass index (BMI) of patients in the oral group, but no significant correlation was detected in injectable group between age and percent of change.
Conclusion: Treatment for vitamin D insufficiency works well when administered intramuscularly and orally but oral group showed more improvement.
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Summary: Oral has bigger response to smaller dose (by VitaminDWiki)
| Oral | Injection | |
| 1st month | 50K weekly for 4 weeks | 200K |
| 2nd month | 50K once a month | 200K |
| 3rd month | 50K once a month | 200K |
| Total IU | 300K | 600K |
| Initial Level | 8.4 ng | 8.4 ng |
| Final level | 26 ng | 21 ng |
| % >20 ng | 100% | 75% |
Doubt that they waited the extra 6+ weeks that injection takes for a peak response
A better experiment would have just given 300K injection once.
Then both groups would get the same dose
and the injection grojup would have 3 months to respond
VitaminDWiki – Injection contains:
- Vitamin D injections last longer (3 month vs 2 month) than loading doses
- Getting Vitamin D into your body shows the many ways of getting Vitamin D
- Injections are currently made by medical professionals into muscle
- Home injection of Vitamin D appears to be possible in the future
- Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
- While Vitamin D2 is historically the common form, Vitamin D3 is far better
- Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
- Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
- 100,000 IU single dose of vitamin D - 2010 has the following
- Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies might include injection
Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017
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