Prediabetes Patients Have Fewer Gut Bugs MedPageToday
News Release for Endocrinology Conference
Significant Differences in Fecal Microbiota Are Associated with Various Stages of Glucose Tolerance in African-American Male Veterans
African American men divided into 4 groups
- stable glucose tolerance,
- stable impaired fasting glucose
or stable impaired glucose tolerance, - worsened glucose tolerance
- improved glucose tolerance.
There were significant differences in bacterial composition between the first and second groups (P=0.03) at the phylum level. Bacteroidetes was higher and Firmicutes was lower with worse glycemic control in the second group.
The Bacteroidetes/Firmicutes ratio was 1.9 versus 0.9 in group 1 and 2 (P=0.01) and 1.9 versus 1.1 in group 1 and 3 (P=0.04).
Proteobacteria decreased over the period in groups 2 and 4 compared to group 1 (P=0.04 for both).
At the family and genus levels, in group 2 versus group 1 there was less Prevotella, and a higher Bacteroides/Prevotella ratio in the second group at 5.6 to 2.7 (P=0.05). There was also less Enterobacteriacea (P=0.03), and more Ruminococcae (P=0.01) and Veillonelacea (P=0.02).
"We speculate that lower abundance of Prevotella may be associated with worsening glycemia, and conversely higher abundance of Akkermansia might be associated with improving glycemia, thus corroborating suggestions from previous studies,"
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