Unveiling the Novel Impact of Vitamin D Injections at Birth on the Prognosis of Newborns: A Double-blind Study
Oman Medical Journal 2024, Vol. 39, No. 4: e650 DOI 10.5001/omj.2024.89
Hassan Boskabadi1, Tahereh Sadeghi2 and Mina Mostafavi1*
- 1 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- 2 Department of Pediatrics, School of Nursing and Midwifery, Nursing and Midwifery Care Research Center, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Objectives: Vitamin D deficiency can harm both the infant and the mother, potentially altering the trajectory of the child’s life. This study aimed to delve into the potentially life-changing impact of vitamin D intake at birth on the prognosis of premature newborns.
Methods: We conducted a double-blind, randomized clinical trial study, between 2021–2022, including 100 infants admitted to the neonatal intensive care unit of Ghaem Hospital in Mashhad, Iran. Premature infants with a gestational age of < 34 weeks and requiring the neonatal intensive care unit admission were randomly allocated into two groups. The intervention group consisted of infants who received 10 000 units of vitamin D, while the control group comprised infants who did not receive any vitamin D at birth. The infants were evaluated based on clinical symptoms, the requirement and duration of oxygen therapy, the necessity and length of mechanical ventilation, the method of oxygen therapy administered, and the length of their hospital stay.
Results: This study included 56 (56.0%) boys and 44 (44.0%) girls. A significant difference was observed between the intervention and control groups regarding maternal age frequency (p =0.013). Additionally, the frequency of mechanical ventilation (p =0.030), surfactant administration (p =0.009), and the number of times surfactant was administered (p =0.020) also showed significant differences between both groups.
Conclusions: Vitamin D intake at birth could potentially revolutionize the management of respiratory complications in premature infants, a crucial discovery for healthcare practitioners and researchers.
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VitaminDWiki – Preterm birth and low Vitamin D - many studies as of Feb 2025 contains
- 2X less risk of respiratory distress syndrome if 50,000 IU of Vitamin D just before premature birth – RCT May 2024
- Supplement preterm infants with vitamin D if less than 80 ng – RCT Sept 2021
- Preemies should have vitamin D supplements – reaching an agreement – April 2021
- Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020
- Vitamin D intervention reduces preterm births and low birth weight by 60 percent – Cochrane Reviews – Nov 2017
- FDA petitioned to acknowledge that vitamin D cuts preterm birth rate in half – May 2018
- Preterm birth is related to Vitamin D Receptor problems – many studies agree
- Preemies have many problems for decades