ASSESSMENT OF VITAMIN D LEVELS AND ITS BIOCHEMICAL MARKERS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A CASE-CONTROL STUDY
Int J Med Pub Health 2024; 14 (2); 741-745 DOI: 10.5530/ijmedph.2024.2.142
P. Yasodamma1, Appari Kanaka Maha Lakshmi2, Bharathi Gangumalla3, Ganedi Seshu Kumari4
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder primarily affecting joints, with systemic implications. Vitamin D, beyond its role in calcium homeostasis and bone health, has immunomodulatory properties. Emerging evidence suggests a link between vitamin D deficiency and RA severity.
Objectives: This study aims to:
- i) Assess serum 25- hydroxyvitamin D levels in RA patients compared to healthy controls
- ii)Analyze biochemical markers associated with vitamin D metabolism in both groups.
- iii)Investigate the correlation between vitamin D levels and RA disease severity.
Material and Methods: A case-control study was conducted over 12 months at an outpatient clinic affiliated with Rangaraya Medical College, Kakinada. The study included 100 participants: 50 RA patients diagnosed per American College of Rheumatology criteria and 50 age- and sex-matched healthy controls. Exclusion criteria included other autoimmune diseases, chronic inflammatory conditions, and current vitamin D supplementation. Baseline demographic and clinical data were collected, along with serum levels of 25- hydroxyvitamin D, calcium, phosphate, parathyroid hormone (PTH), C- reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Statistical analyses included independent t-tests, Pearson correlation, and multivariate regression.
Results: RA patients exhibited significantly lower serum 25-hydroxyvitamin D levels (15.4 ± 5.2 ng/mL) compared to controls (28.6 ± 6.3 ng/mL, p < 0.001). They also had elevated PTH, CRP, and ESR levels, and reduced serum calcium. A significant negative correlation was found between vitamin D levels and RA disease activity (DAS28, r = -0.42, p = 0.003). Multivariate regression identified RA duration, DAS28 score, serum calcium, PTH, and CRP as independent predictors of vitamin D deficiency.
Conclusion: RA patients show significant vitamin D deficiency, correlating with disease severity. Monitoring and addressing vitamin D levels may be crucial in managing RA.
Download the PDF from VitaminDWiki
VitaminDWiki – Rheumatoid Arthritis category contains
Highlights of RA studies in VitaminDWiki
RA worse if low Vitamin D
- Rheumatoid Arthritis score extrapolates to zero at 51 ng of Vitamin D (India) – June 2024
- Rheumatoid Arthritis is more severe if low vitamin D – July 2023
- Rheumatoid arthritis pain was 5.8 X more likely if low vitamin D – Aug 2017
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Rheumatoid Arthritis strongly associated with low vitamin D – meta-analysis April 2016
- Rheumatoid Arthritis associated with lower vitamin D and higher latitude – meta-analysis Jan 2016
- Adaptive and innate immune system, vitamin D genes, and Rheumatoid Arthritis – June 2019
- Resveratrol Role in Autoimmune Disease-A Mini-Review. – Dec 2016
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Arthritis runs in Pakistani families (Vitamin D Receptor) – March 2019
- Juvenile idiopathic arthritis 2.2 X more likely if poor Vitamin D Receptor – Aug 2018
- Juvenile Rheumatoid Arthritis 8 X more likely if poor Vitamin D receptor – Dec 2017
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Vitamin D in rheumatoid arthritis-towards clinical application – April 2016
- Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
- Rheumatoid arthritis, genes and vitamin D – May 2013
RA Treated by Vitamin D
- Several rheumatic diseases treated by high-dose vitamin D, but made worse if Calcium was added – April 2022
- Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Rheumatoid arthritis reduced by 440,000 IU of Vitamin D over 4 months – Oct 2015
- Connective tissue disorders (Lupus, RA, etc) treated by vitamin D – May 2016
- 43 percent of Rheumatoid Arthritis patients have Vitamin D prescriptions (15 countries) – June 2017
- Big increase in vitamin D supplementation in just 2 years after Swiss rheumatology report – Dec 2013
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Note: Vitamin D receptor problems (such as RA) are best treated by infrequent large doses of Vitamin D
| 697 visitors, last modified 05 Jul, 2024, |
| ID | Name | Uploaded | Size | Downloads | |
|---|---|---|---|---|---|
| 21395 | RA Score.webp | admin 05 Jul, 2024 | 19.10 Kb | 83 | |
| 21394 | RA score.pdf | admin 05 Jul, 2024 | 106.28 Kb | 42 |