Table of contents
Thyroid and parathyroid related items in VitaminDWiki
82 items in the category - See also Overview Hyperparathyroidism and vitamin D
- Overview Thyroid and Vitamin D
- PTH 4470 items as of Feb 2020
- "GRAVES DISEASE" 428 items as of Feb 2020
Intervention AND Thyroid/Parathyroid
- Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021
- Vitamin D not help when not give enough (Graves Disease in this case – 26 ng) – Jan 2020
- Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019
- Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
- 2800 IU of vitamin D before and after parathyroid surgery helped a lot – RCT Jan 2014
- 50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism – Jan 2013
VitaminDWiki pages with HASHIMOTO'S in title (8 as of Jan 2023)
This list is automatically updated
Items found: 8Hashimoto's is associated with low Vitamin D - meta-analysis - Dec 2021
Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis
J Int Med Res. 2021 Dec;49(12):3000605211060675. doi: 10.1177/03000605211060675.
Jingwen Zhang 1, Yuting Chen 2, Hongyan Li 1, Hong Li 1Objective: To perform a meta-analysis of randomized controlled trials to evaluate the efficacy of vitamin D supplementation on thyroid autoimmunity markers in Hashimoto's thyroiditis (HT).
Methods: This meta-analysis included randomized controlled clinical trials identified by a systematic search of electronic databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to August 2020. All studies included patients with HT that received vitamin D supplementation irrespective of the doses administered or the duration of treatment. The primary and secondary outcome measures were thyroid peroxidase antibody (TPOAb) and/or thyroglobulin antibody (TGAb) titres.
Results: Eight studies (n = 652) were included. There was significant heterogeneity between the studies. Using a random-effect model, vitamin D supplementation reduced TPOAb titre (standardized mean difference SMD: -1.11; 95% confidence interval CI: 1-1.92, -0.29) and TGAb titre (SMD: -1.12; 95% CI: -1.96, -0.28). A subgroup analysis demonstrated that vitamin D supplementation for >3 months resulted in a decrease in TPOAb titre (SMD: -1.66, 95% CI: -2.91, -0.41) but treatment ≤3 months was ineffective. Treatment with vitamin D3 decreased TPOAb titre (SMD: -1.48; 95% CI: -2.53, -0.42) whereas vitamin D did not.
Conclusion: These data suggest that vitamin D reduces autoantibody titre in patients with HT.
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Thyroid on the web
- Overtreatment of Indolent Thyroid Tumors JAMA April 2016
Nothing about Vitamin D, Full text online - Vitamin D and thyroid diseases 2015
"levels below 12.5 ng/ml should be considered as an additional, but important risk factor for development of thyroid autoimmunity, both chronic autoimmune thyroiditis and Graves' disease"
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All of the articles
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- Extended-Release Calcifediol is useful for Hyperparathyroidism - Sept 2024
- Thyroidectomy and Vitamin D - many studies
- PTH and Vitamin D - many studies
- Hashimoto's thyroiditis: Vitamin D was the most important of 11 variables – Aug 2022
- Maasai have PTH and bone resorption (CTX) circadian rhythms – April 2022
- Vitamin D cannot distinguish between thyroid cancer and other thyroid problems – all have low levels – Feb 2022
- High Vitamin D associated with 3.4 X less risk of possibly Cancerous Thyroid Nodules - Feb 2022
- 1.8 X more heart medicines needed by children after heart surgery if low Vitamin D – July 2021
- Parathyroid response to Vitamin D among obese
- Parathyroid hormone level is inversely associated with both Vitamin D and age – April 2021
- Half as many problems if take Vitamin D (300,000 IU) before thyroidectomy – RCT Jan 2021
- Parathyroid increase with age associated with worsening Vitamin D genes – April 2020
- Vitamin D not help when not give enough (Graves Disease in this case – 26 ng) – Jan 2020
- Chronic Hypoparathyroidism typically uses daily Calcium, alternate day is 7X better – Jan 2019
- PTH failed to decrease with Vitamin D if overweight and had low Magnesium – Aug 2019
- Magnesium, Vitamin D, Omega-3, TSH - importance and testing - Dean and Baggerly - Oct 2019
- Parathyroid – Vitamin D inflection points might be at both 16 and 32 ng – Oct 2019
- Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019
- Hashimoto's thyroiditis 3.2 X more likely if low vitamin D – meta-analysis May 2019
- Graves' disease 1.4 X more likely if poor Vitamin D Receptor – March 2019
- Patent to treat secondary hyperparathyroidism with 30 ng Vitamin D – March 2018
- Primary hyperparathyroidism surgery associated with 8 X increased risk of bone fracture if low vitamin D – May 2018
- Thyroid and vitamin D are the only body components which have a receptor on every cell in the body
- Heart Failure is predicted by PTH (but vitamin D both prevents and treats HF) – Jan 2018
- Increased occurrence of Graves' and Hashimoto's diseases if poor Vitamin D genes – Nov 2014
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
- Parathyroid Hormone levels increase 63 percent with age (33,000 people) – Sept 2017
- Thyroid problems more than double when both Vitamin D and Iodine are low – Sept 2017
- The Role of Vitamin D in Thyroid Diseases – Sept 2017
- Ischemic Stroke risk best predicted by Vitamin D, including PTH improves the prediction – Feb 2017
- Sunshine vitamin and thyroid – Jan 2017
- Sunshine vitamin and thyroid - Jan 2017
- Thyroid diseases and vitamin D – review 2015
- Lots of vitamin D supplementation by those with Primary Hyperparathyroidism – Sept 2015
- Graves' disease and Hashimoto's thyroiditis 1.5X less likely for each 2 ng more vitamin D – Sept 2015
- 3000 IU of vitamin D minimum to reduce parathyroid hormone (PTH) – meta-analysis Sept 2015
- Hypothesis Vitamin D receptor controls PTH without needing Vitamin D – Aug 2015
- Critically ill injected with 300,000 IU of vitamin D, 3X more likely to die if PTH did not respond - RCT July 2015
- Graves Disease is 2.2X more likely with low vitamin D – meta-analysis May 2015
- Autoimmune Thyroid Disease 3X more likely if low vitamin D – meta-analysis April 2015
- Following primary hyperparathyroidism surgery 1600 IU vitamin D was not enough to help - RCT Feb 2015
- PTH reduced 3.5 pmol by vitamin D intervention which added 22 ng – meta-analysis June 2014
- Vitamin D helps with T2 Diabetes, hyperparathyroidism, PCOS, and some other endocinological diseases – Sept 2014
- Diabetes after giving birth was associated with low vitamin D combined with high PTH – May 2014
- Hyperparathyroidism – still not absolutely, positively sure that vitamin D should be used to treat it – March 2014
- 2800 IU of vitamin D before and after parathyroid surgery helped a lot – RCT Jan 2014
- Autoimmune Thyroid Disease 2X more likely if low vitamin D – Dec 2013
- Fix Thyroid then increase vitamin D - Oct 2013
- Long term Hashimoto's Thyroiditis has lower level of vitamin D – Jan 2013
- 50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism – Jan 2013
- Thyroid and parathyroid
- Worse diabetic vision is associated with low vitamin D or high PTH - Nov 2012
- African-Americans need only 20 ng of vitamin, not 30 ng, based on iPTH – Sept 2012
- PTH does not plateau with increasing vitamin D, but does decrease with patient age – Aug 2012
- Calcium and bone disorders in pregnancy – May 2012
- Hypothesis: Primary hyperparathyroidism might increase when vitamin D levels increase – Aug 2012
- 2X more Thyroid Cancer malignancy if less than 15 ng of vitamin D – June 2012
- Variations in Parathyroid Hormone Concentrations in Patients with Low Vitamin D – June 2012
- PTH boosts immune response when vitamin D levels are low – May 2012
- Vitamin D testing typically not needed, but in 9 cases it is – April 2012
- Interaction between Vitamin D and calcium – April 2012
- Primary Hyperparathyroidism perfectly predicted with a Vitamin D-Based nomogram – Nov 2011
- Children have PTH problems when vitamin D is less than 15 ng – Nov 2011
- Hashimoto's Thyroiditis and Vitamin D - multiple studies
- Need 40 ng of vitamin D to have proper PTH levels – May 2011
- Chronic kidney disease and PTH – Calcium – Phosphate – Vitamin D – April 2011
- Vitamin D and autoimmune thyroid diseases. – Jan 2011
- Vitamin D and Primary Hyperparathyroidism – 2011, 2016
- Overview Thyroid and Vitamin D
- Every Thyroidectomy patient should get vitamin D and Calcium – Nov 2010
- Patients low on vitamin D stay in hospital longer after thyroid removal – Dec 2010
- Price and Masterjohn on Vitamin A Vitamin D and Vitamin K – 2010
- Review concludes that vitamin D and Calcium help after thyroid removal – Aug 2010
- Overview Hyperparathyroidism and vitamin D
- PTH needs vitamin D level higher than 13 ng – Cohort June 2010
- Iodine deficiency might cause obesity
- Survey Shows Dogma Not Data Can Dictate Doctors' Decisions - June 2010
- Japanese decided that 28 ng mimimum for proper parathyroid hormone – June 2010
What is the difference between the Intact Parathyroid Hormone and the Parathyroid Hormone (asked AI)
The difference between Intact Parathyroid Hormone (iPTH) and Parathyroid Hormone (PTH) primarily lies in the specific forms of the hormone that each assay measures and their clinical utility.
Intact Parathyroid Hormone (iPTH)
The iPTH assay measures the level of 1-84 PTH, which is the full, active form of the hormone, along with large truncated fragments of non-1-84 PTH, including 7-84 PTH. This assay is widely used, especially in the context of managing patients with chronic kidney disease, including those on dialysis, to assess parathyroid function and secondary hyperparathyroidism. The iPTH assay is considered the standard measurement for PTH in clinical practice and is used for approximately 90% of Japanese dialysis patients 1.
Parathyroid Hormone (PTH)
When referring to PTH without specifying "intact," it generally encompasses the entire spectrum of PTH forms, including both the active form and various inactive fragments. However, the term "whole PTH" specifically refers to assays that measure only the 1-84 PTH molecule without the inactive fragments. The whole PTH assay is more specific for the active form of the hormone and may provide a more accurate reflection of parathyroid function in certain clinical scenarios 1 .
Key Differences and Clinical Implications
Assay Specificity: The iPTH assay measures both the active form of PTH (1-84) and its large truncated fragments (e.g., 7-84 PTH), whereas the whole PTH assay specifically measures only the 1-84 PTH molecule 1.
Clinical Utility: The iPTH assay is widely used in managing patients with chronic kidney disease and secondary hyperparathyroidism. It has a high correlation with non-1-84 PTH fragments, which can be significant in certain patient populations. On the other hand, the whole PTH assay, by focusing solely on the active form of the hormone, may offer a more precise evaluation of parathyroid function in specific contexts 1.
Interpretation and Misclassification: Studies have shown that there can be significant differences in the classification of parathyroid hormone status between the iPTH and whole PTH assays, with a portion of patients potentially being misclassified into different guideline categories based on the assay used. This highlights the importance of assay selection in the accurate diagnosis and management of parathyroid-related disorders 1.
In summary, while both iPTH and PTH assays are used to evaluate parathyroid function and manage related disorders, they differ in their specificity and the forms of PTH they measure. The choice between these assays depends on the clinical context, with the iPTH assay being more commonly used in practice due to its broader measurement of PTH forms, including both active and inactive fragments 1.
Details, hyperlinks, images, etc. are at Perplexity Feb 2024Thyroid and parathyroidPrinter Friendly Follow this page for updates68714 visitors, last modified 29 Feb, 2024, This page is in the following categories (# of items in each category)