Asthma is also fought by Magnesium - several studies

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How does Magnesium fight asthma (prevent and treat) - asked Perplexity AI Dec 2024

Magnesium plays multiple important roles in both preventing and treating asthma through several key mechanisms:
Prevention Mechanisms
Anti-inflammatory Effects
Magnesium helps prevent asthma attacks by dampening inflammation in the airways and stabilizing mast cells 1 8
 It also blocks the release of chemicals that cause airway inflammation 9
Smooth Muscle Function
The mineral acts as a calcium channel blocker, helping to maintain relaxed bronchial smooth muscles and prevent constriction of airways 7 8
 This bronchodilating effect is particularly important since asthma involves hyperresponsive airway smooth muscles 4
Treatment Applications
Emergency Treatment
Intravenous magnesium sulfate serves as an effective emergency treatment when first-line therapies fail 6
 It reduces hospital admission rates by:

• 68% in children
• 25% in adults 6

Therapeutic Mechanisms
During an acute asthma attack, magnesium provides relief through multiple pathways:

• Relaxes and opens constricted airways
• Blocks chemicals causing muscle spasms
• Increases nitric oxide levels to reduce inflammation
• Inhibits cholinergic neuromuscular transmission 1 7

Supplementation Effects
Oral Supplements
Daily oral magnesium supplementation can improve:

• Peak expiratory flow rate
• Forced expiratory volume
• Overall lung function parameters 1 3

However, while some studies show promise for oral supplementation, more research is needed to definitively establish its effectiveness in preventing asthma attacks 1 9

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Causal effect of serum magnesium on the risk of 9 respiratory diseases: a Mendelian randomization study

preprint https://doi.org/10.21203/rs.3.rs-3342596/v1FREE PDF
Jingtao Zhang, Yang Li, Zhaohao Huang, Zhiguo Chen, Xuxing Wu, and 1 more

Objective: Although the association between serum magnesium and respiratory diseases has been explored, the causal effects of serum magnesium on respiratory diseases are largely unknown. Here we performed a Mendelian randomization(MR) analysis to investigate the association between serum magnesium concentrations and risk of 9 respiratory diseases.

Methods: Mendelian randomization was conducted using single-nucleotide polymorphisms(SNPs) associated with serum magnesium as instrumental variables.To select SNPs, we used publicly available summary-level data from Genome-wide association studies (GWASs). We used inverse-variance weighted (IVW), weighted median, MR-Egger regression approaches in this analysis.The IVW method was used in the primary analysis to obtain the causal estimates.

Results: Genetically predicted serum magnesium was inversely associated with the risk of asthma.The odds ratios in genetically predicted serum magnesium concentrations was 0.229 (95% confidence interval [CI] 0.065-0.806; p=0.022),which was further confirmed by multiple sensitivity analyses. Other diseases such as pulmonary embolism, lobar pneumonia, COVID-19, lung adenocarcinoma, lung squamous cell carcinoma, bronchiectasis, tuberculosis and interstitial lung disease did not yield statistically significant results.

Conclusions: High genetically predicted serum magnesium was causally associated with a decreased risk of asthma and suggested that serum magnesium concentrations may be crucial to prevent the onset of asthma.

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Role of nebulised magnesium sulfate in treating acute asthma in children: a systematic review and meta-analysis - May 2024

BMJ Paediatr Open. 2024 May 23;8(1):e002638. FREE PDF

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Magnesium for treatment of asthma in children - Sept 2009

Canadian Family Physician September 2009; 55 (9) 887-889;
Marcela Davalos Bichara and Ran D. Goldman

QUESTION Magnesium is considered adjuvant therapy for moderate to severe asthma exacerbations in adults, but can it be used to treat children?

ANSWER Magnesium seems to be beneficial in the treatment of moderate to severe asthma in children. It is a safe drug to administer, but there have been minor side effects reported, such as epigastric or facial warmth, flushing, pain and numbness at the infusion site, dry mouth, malaise, and hypotension. Owing to its bronchodilating and anti-inflammatory effects, magnesium is an encouraging adjuvant therapy for pediatric patients who do not respond to conventional treatment in acute severe exacerbations. Future studies should focus on establishing the optimal dosage for maximal benefits and the best route of administration. Magnesium should also be considered as a prophylactic treatment.
 Download the PDF from VitaminDWiki

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Study The Relation Between Serum Magnesium level and The Severity of Asthma Oct 2023

. Kirkuk Journal of Medical Sciences, 2023; 11(2): 51-63. FREE PDF
Yousif Muhammad Hassan1, Muhammed W. AL Obiady 2

• Background: Asthma is one of the most common chronic diseases globally and has been increasing in prevalence over the last few decades. The aim of this study is to assess the serum Magnesium levels in bronchial asthma patients in relation to severity stage.
• Methods: A case control study conducted at Baghdad Teaching Hospital at Baghdad Medical City complex of fifty patients were diagnosed as bronchial asthma according to GINA guideline and fifty healthy individuals as a control group.
• Result: Serum Magnesium levels were lower in asthmatic patients (36%), compared with healthy controls (4%), and significantly lower in asthmatic patients during exacerbation compared with stable asthmatics.
• Conclusions: Serum Magnesium levels have a positive correlation with the level of symptom control in asthma. In uncontrolled asthma, serum Magnesium is significantly low. Hence, it might be useful as a biomarker in assessing control or severity of asthma.

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Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity - Oct 2016

Pulmonary Medicine FREE PDF
Mohammed Nadeem Shaikh, Brahma Reddy Malapati, Ruchi Gokani, Bhavita Patel, Mitul Chatriwala

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3+ VitaminDWiki Magnesium pages have ASTHMA in the title

The list is automatically updated

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VitaminDWiki – Overview Asthma and Vitamin D contains

• VitaminDWiki pages containing ASTHMA in title (164 as of Nov 2024)
• Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014
  • Started with 100,000 IU loading dose and has standard-of-care Asthma drug
• Asthma may be treated by Vitamin D if more than 40 ng for 12 months – Sept 2018
• Those with Asthma or COPD had half the response to Vitamin D – March 2020
  • Those with Asthma need larger doses to get the same response.
  • Probably need gut-friendly Vitamin D
• CDC funded study: 1.3 X Asthma risk if vaccination contained aluminum – Sept 2022
• Asthma occurrence rate reduced 3X by Vitamin D – 8 study meta-analysis - Aug 2021
• Asthma in child 2.3 X more likely if both parents asthmatic (unless add Vitamin D) – VDAART Nov 2018
• Adult-onset asthma 2X more likely if low vitamin D and not hyperallergenic – May 2018
• Children had poor lung function if mothers had low vitamin D while pregnant – Nov 2022
• 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
  • CDC list of high-risk for COVID-19 includes Asthma
• Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018
• Asthmatic children taking Corticosteroids had 2X more vitamin D intake, but lower levels – July 2017
• Traffic pollution increases asthma unless supplement with Vitamin D (mice) June 2018
• Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
• Proof that Vitamin D Works 92 health problems prevented/treated as of Nov 2020
  • Asthma has been proven to be treated by Vitamin D in at least 4 random controlled trials
• Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016
• Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019
• Women with asthma 35X more likely to be vitamin D deficient – Oct 2013
• If high vitamin D during pregnancy the child is 5X less likely to get asthma
• Asthma is treated by Vitamin D – now they are trying to understand why – Feb 2015
• Increase in vitamin D deficiency may partially explain increases in asthma and allergies – Jan 2015
• Why deficiencies in vitamin D and magnesium are linked to asthma Magnesium allows muscles to relax
• Babies 3.6X more likely to go to hospital for asthma if asthmatic mother had low vitamin D while pregnant – June 2019
• The worse the bronchial asthma, the lower the vitamin D – Jan 2017 has the following chart

click on the chart to see the study

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VitaminDWiki – Magnesium and Vitamin D contains

369 items in category, see also

• Overview Magnesium and vitamin D
• Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
• The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
• Magnesium deficiency – causes and symptoms – May 2016
• Magnesium Depletion Score predicts increased risk of various health problems
• Vitamins and Metals needed by the Immune System – Jan 2020
• Magnesium: intake decreased, difficult to measure in body – Sept 2018
• Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
• Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
• Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
• Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
• Magnesium is important for health but levels are low – July 2018
• How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
• Magnesium etc. reduced in crops (must supplement) – 2009

Magnesium and Vitamin D

• Intracellular Magnesium and Vitamin D - a few studies
• Vitamin D and Magnesium need each other - many studies
• Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
• 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
• Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
• Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
• Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
• Vitamin D Cofactors in a nutshell
• Magnesium and Vitamin D - similar, different and synergistic

12+ VitaminDWiki Magnesium pages have MANY STUDIES in the title
The list is automatically updated

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Associations between Magnesium and other categories

Omega-3 33,  Diabetes 27,  Vitamin K 27,  Calcium 26,  Virus 25,  Zinc 24,  Cardiovascular 17,  Bone - Health 15,  Vitamin B12 15,  Iron 14,  Depression 14,  Supplement 12,  Vitamin C 11,  Obesity 11,  Hypertension 11,  Headache 10,  Boron 10,  Pregnancy 10,  Metabolic Syndrome 9,  Intervention 9,  Mortality and D 8,  Iodine 8,  Seniors 8,  Deficiency of Vitamin D 8,  Books,   videos on Vitamin D 7,  Pain - chronic 7,  Resveratrol 7,  Interactions with Vitamin D 6,  Vitamin D and Vitamin A 6,  Cognitive 6,  Falls and Fractures 5,  Trauma and surgery 5,  Kidney 5,  Women 5,  Osteoporosis 4,  Breathing 4,  Infant-Child 4,  ADHD 4,  Cancer - Breast 4,  Cancer - Colon 4,  Predict Vitamin D 4,  Associations 4,  Off Topic 4,  Curcumin 4 (Nov 2023)

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VitaminDWiki – Vitamin D, Omega-3, and Magnesium are synergistic - many studies

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2+ VitaminDWiki Omega-3 pages have ASTHMA in the title

The list is automatically updated

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40,500 studies contain both Omega-3 and Asthma - Dec 2024

Google Scholar

• The Effects of Omega-3 Fatty Acids Supplementation in Bronchial Asthma - April 2023 FREE PDF
  • RCT success: Omega-3, Vitamin C, plus Zinc
• Primary Prevention of Pediatric Asthma through Nutritional Interventions - Feb 2022 FREE PDF

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Has there been any use of vitamin D and Magnesium to treat asthma? – asked Perplexity AI Dec 2024

Vitamin D and magnesium have shown promising potential in asthma management through several mechanisms and clinical studies.
Vitamin D's Role
Mechanisms of Action
Vitamin D helps manage asthma by reducing airway inflammation, suppressing proinflammatory cytokines, and decreasing airway smooth muscle proliferation  1
It can also attenuate viral-induced asthma attacks by reducing rhinovirus replication and promoting antiviral pathways  6
.Clinical Evidence
Vitamin D supplementation has shown a 30% reduction in asthma exacerbations in patients with mild to moderate asthma and low vitamin D levels  2
This is particularly significant in patients with baseline vitamin D levels below 25 nmol/L  2
Magnesium's Role
Mechanisms of Action
Magnesium functions by:

• Inhibiting smooth muscle contraction
• Reducing acetylcholine release from nerve endings
• Decreasing histamine secretion from mast cells
• Supporting respiratory muscle function  1

Clinical Findings
Low magnesium levels are significantly associated with increased asthma severity and poor disease control  4
Studies have shown that serum magnesium levels progressively decrease as asthma severity increases  4
Combined Effects
The relationship between these nutrients is significant, as serum magnesium levels affect circulating vitamin D concentrations  4
Both vitamin D and magnesium deficiencies are highly prevalent in asthmatic patients, and their low levels correlate with:

• More frequent asthma attacks
• Increased respiratory infections
• Severe exacerbations
• Limited response to bronchodilators  7

Treatment Implications
While evidence supports the role of these nutrients in asthma management, supplementation should be considered in the context of deficiency. Vitamin D supplementation represents a low-cost, low-risk approach to treating and controlling asthma when deficiency is present   2

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What are the recommended doses of Vitamin D and Magnesium for asthma patients – asked Perplexity AI Dec 2024

Vitamin D Dosing
For Adults

• 400-4,000 IU per day has shown effectiveness in reducing asthma exacerbations  1
• Most beneficial effects are seen in vitamin D deficient patients (<25 nmol/L)  1
• Treatment can reduce asthma exacerbations by approximately 30% in deficient adults  2

For Children

• For vitamin D deficient children: 50,000 IU initial dose followed by 8,000 IU daily  4
• The Endocrine Society recommends weekly doses of 50,000 IU vitamin D2 for deficient children   2

Magnesium Dosing
Intravenous Administration

• Standard dose: 25-75 mg/kg up to 2g for bronchodilation  3
• Typical administration time is 20-35 minutes  3
• Used primarily for acute severe exacerbations  9

Oral Supplementation

• Studies have used various doses:
  • 200-290 mg magnesium citrate
  • 340 mg magnesium citrate
  • 450 mg magnesium amino-chelate
  • 300 mg magnesium glycine  6

Safety Considerations
The risk of major toxicity from magnesium is minimal at standard doses in patients with normal renal function  10
. For vitamin D, doses within the mentioned ranges are considered safe and represent a low-cost, low-risk approach to treating asthma when deficiency is present  2