Loading...
 
Toggle Health Problems and D

Better response 6 months after Pfizer vaccinations if higher vitamin D – Aug 2022


Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2

Biomedicines. 2022 Aug 17;10(8):1993.doi: 10.3390/biomedicines10081993.
Paola Zelini 1 , Piera d'Angelo 2 , Emanuele Cereda 3 , Catherine Klersy 4 , Peressini Sabrina 5 , Riccardo Albertini 5 , Giuseppina Grugnetti 6 , Anna Maria Grugnetti 6 , Carlo Marena 7 , Sara Cutti 7 , Daniele Lilleri 1 , Irene Cassaniti 1 8 , Baldanti Fausto 1 8 , Riccardo Caccialanza 3

The use of micronutrients such as vitamin D could improve the response to viral vaccines, particularly in immunosuppressed and immunosenescent subjects. Here, we analysed the association between serum 25-hydroxyvitamin D (25OHD) levels and the immune response elicited by the BNT162b2 vaccine in a cohort of 101 healthcare workers naïve for SARS-CoV-2 infection. We observed no significant differences in anti-spike (S) IgG and T-cell responses according to the 25OHD status at baseline. However, significant correlations between the 25OHD concentration at baseline and (i) the anti-S response (p < 0.020) and (ii) the neutralizing antibody (NT) titre (p = 0.040) at six months after the second dose were detected. We concluded that adequate levels of vitamin D may improve the immune response to mRNA vaccines such as BNT162b2, and that further larger studies are warranted in order to confirm these preliminary observations.
 Download the PDF from VitaminDWiki



Created by admin. Last Modification: Saturday August 27, 2022 16:22:44 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
18343 Pfizer 6 month_CompressPdf.pdf admin 27 Aug, 2022 233.13 Kb 153