- Association between vitamin D and bladder neoplasm; a systematic review and meta-analysis
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6 Meta-anayses of Bladder Cancer
Association between vitamin D and bladder neoplasm; a systematic review and meta-analysis
Journal of Nephropharmacology DOI: 10.34172/npj.2024.11668
Anna Ghorbani Doshantapeh'|lj, Mohammad Hamidi Madam2!«, Ali Khodaparast’’!«, Rasoul Jafari Ai-ismaiii'!«, Ardeshir Matoofi5«, Delnia Heidari'l«, Golmis Abdolmohammadi7!«, Farshad Gharebakhshi8,9 , Jahanbakhsh Vahdatnejad10*Introduction: Bladder neoplasm ranks as the second most prevalent reproductive system malignancy worldwide. On the other hand, the vitamin D as an anti-cancer agent has been a subject of long-standing speculation. Hence, the objective of this study is to explore the correlation between vitamin D and bladder neoplasm risk.
Materials and Methods: This systematic review and meta-analysis were designed following the PRISMA checklist. Eligible studies were identified through searches on ProQuest, PubMed, Web of Science, Google Scholar, and Cochrane, with no time restrictions until November 18, 2023. Data analysis was conducted utilizing the STATA 14 software.
Results: Serum vitamin D levels less than 50 nmol/L increased the risk of
- bladder neoplasm (OR: 1.33; 95% CI: 1.08, 1.64),
- muscle-invasive bladder cancer (MIBC) (OR: 2.73; 95% CI: 1.80, 4.14) and
- non-muscle invasive bladder cancer (NMIBC) (OR: 1.87 (95% CI: 1.39, 2.52)).
However, the risk of bladder neoplasm in people whose serum vitamin D level was less than 50 nmol/L did not increase with age. Vitamin D serum levels greater than or equal to 50 nmol/L in people aged 40 to 49 (OR: 0.51; 95% CI: 0.27, 0.99) prevented bladder neoplasm, but no significant association was seen in people over 50 years old. In addition, there was no significant association between daily vitamin D intake and the risk of bladder neoplasm (OR: 1.13; 95% CI: 0.63, 2.06).
Conclusion: The serum vitamin D less than 50 nmol/L was correlated with bladder cancer risk increasing, including MIBC and NMIBC.
VitaminDWiki -
6 Meta-anayses of Bladder Cancer This list is automatically updated
- Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016
- Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015
- Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015
- Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014
Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024Printer Friendly Follow this page for updates68 visitors, last modified 23 May, 2024, This page is in the following categories (# of items in each category)