Effects of vitamin D supplementation on patients with chronic heart failure: A meta-analysis
Nutrition Clinique et Métabolisme https://doi.org/10.1016/j.nupar.2024.05.001
Objective
To systematically evaluate the effect of vitamin D supplementation on cardiac function in patients with chronic heart failure.
Methods
Search multiple databases to find randomized controlled trials of vitamin D for chronic heart failure from the self-built database until September 1, 2023. Meta-analysis was performed using RevMan5.3 and Stata15.0 software.
Results
Eighteen articles were included. Vitamin D supplementation has
improved
- left ventricular ejection fraction [WMD = 3.18%, 95%CI (1.07, 5.3), P < 0.05] and
- 6-minute walking distance [MD = −11.54, 95%CI (−22,215, −0.871), P < 0.05], has
decreased
- left ventricular end-diastolic diameter [MD = −1.67, 95%CI (−2.88, −0.46), P < 0.05],
- left ventricular end-diastolic volume [MD = −11.94, 95%CI (−20.59, −3.29), P < 0.05],
- N-terminal forebrain natriuretic peptide [WMD = −0.7, 95%CI (0.24, 1.16), P < 0.05].
Conclusion
Vitamin D supplementation can improve cardiac function, inhibit ventricular remodeling, and increase exercise endurance inpatients with chronic heart failure.
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