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Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012

Vitamin D Deficiency, Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis

Dement Geriatr Cogn Disord 2012 Vol. 33, No. 5, 2012 ;33:297-305
Thorleif Etgena,b thorleif.etgen at klinikum-traunstein.de, Dirk Sanderc,d, Horst Bickela, Kerstin Sanderd, Hans Förstla
A Department of Psychiatry and Psychotherapy, Technische Universität München,
B Department of Neurology, Kliniken Südostbayern – Klinikum Traunstein,
C Department of Neurology, Benedictus Krankenhaus Tutzing, and
D Department of Neurology, Technische Universität München, Munich, Germany

Background: Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency.

Methods: A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency.

Results: Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency.
Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91–3.00; p < 0.0001).

Conclusions: Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started.

Copyright © 2012 S. Karger AG, Basel

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Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012

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- VitaminDWiki Mega-Search (Interim Version) MegaSearchOverview Vitamin D and neurocognitive function – Holick April 2014 Postoperative cognitive dysfunction 8 X more likely if low vitamin D – March 2018 Vitamin D deficiency 4.7 times more likely in bipolar disorder, schizophrenia, or schizoaffective disorder – Sept 2016 Slower cognitive decline if higher vitamin D (1500 adults, 5 years) – Feb 2018 Diabetics with low vitamin D had more cognitive impairment– Aug 2013 Dementia 13X more likely in elderly with low vitamin D – May 2014 Seniors able to remember new information 2X better if OK vitamin D – Feb 2018 Short-term memory 2X better for those who took slightly more vitamin D 14 years before – Sept 2014 "Senior moment" 25X more likely with low vitamin D - Feb 2012 Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 Preeclampsia doubles the risk of mild cognitive impairment – July 2017 Teens able to think better after vitamin D levels raised to just 25 nanograms – RCT April 2017 Poor memory (among diabetics) if have low vitamin D – Aug 2015 Low vitamin D associated with cognition in women who were 5 years older – Oct 2013 Better memory if take lots of vitamin D (senior rats) – May 2015 2X better attention and working memory if high vitamin D among seniors living in communities – April 2015 More depression associated with more dementia in seniors (vitamin D not mentioned) – July 2014

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