A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre‐diabetes
BioFactors , 01 October 2019 https://doi.org/10.1002/biof.1569
Nahid Karamzad Vahid Maleki Kristin Carson‐Chahhoud Samaneh Azizi Amirhossein Sahebkar Bahram Pourghassem Gargari
Items in both categories Diabestes and Vitamin K are listed here:
- T2 Diabetes is also fought by Vitamin K2 – several studies
- Vitamin K2-7 helps bone, blood vessels, cancer, diabetes, etc. – June 2022
- Diabetes and pre-diabetes helped by Vitamin K in animal studies – review Oct 2019
- Importance of Vitamin K – Pizzorno – July 2018
- Vitamin K2 substantially reduces risk of T2 Diabetes (7 percent for every 10 ug) – review Nov 2017
- The health benefits of vitamin K – Oct 2015
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
553 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 57 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 30 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Overview Vitamin K and Vitamin D contains the following summary
Vitamin K2 is similar to D3 in many ways
- Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
- Both vitamins appear to influence health in large number of ways
- Both vitamins in the body are about 1/10 that of a century ago
Example: Grass-fed beef has a lot more K2, D3, and Magnesium - Need very little of both vitamins: <1 milligram daily
- When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
- Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
One of the reasons: [https://www.perplexity.ai/search/is-there-a-vitamin-k2-blood-te-vVTdLPwcTFyi1Z_PM8yvTw|No simple blood test for K2 as of Dec 2024]
Diabetes mellitus and pre‐diabetes are prevalent endocrine disorders associated with substantial morbidity and premature mortality. Vitamin K is known to have several beneficial effects on complications of diabetes and pre‐diabetes. However, systematic consolidation of evidence is required to quantify these effects in order to inform clinical practice and research. A systematic search in PubMed, Scopus, Embase, ProQuest, and Google Scholar databases was undertaken from database inception up to October 2018 to evaluate functional roles of different forms of vitamin K on diabetes and pre‐diabetes. From 3,734 identified records, nine articles met the inclusion criteria and were evaluated.
Vitamin K supplementation was found to be associated with significant reductions in- blood glucose (six studies),
- increased fasting serum insulin (four studies),
- reduced hemoglobin A1c (three studies),
- reduced homeostatic model assessment‐insulin resistance index (HOMA‐IR) (two studies), and
- increased ß‐cell function (two studies)
in diabetic animal studies. Following 2‐hour oral glucose tolerance test, vitamin K supplementation was observed to be effective in reducing blood glucose and insulin levels in the pre‐diabetic population. However, no evidence of effect was observed for fasting blood sugar, insulin, HOMA‐IR, and homeostatic model assessment‐β‐cell function index (two studies).
A statistically significant effect was also noted with vitamin K in improving- dyslipidemia (three studies) as well as
- oxidative stress and inflammatory markers (five studies)
in diabetic animals. In conclusion, clinical trials and animal studies confirm that vitamin K supplementation may improve both clinical features and complications of diabetes and pre‐diabetes. However, quantification of clinical efficacy in the pre‐diabetic population and among individuals with comorbidities requires further investigation.
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Diabetes and pre-diabetes helped by Vitamin K in animal studies – review Oct 2019(Cached) Printer Friendly Follow this page for updates4368 visitors, last modified 02 Oct, 2019, This page is in the following categories (# of items in each category)