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How active vitamin D (Calcitriol) deals with cancer – June 2015

Mechanistic Effects of Calcitriol in Cancer Biology.

Nutrients. 2015 Jun 19;7(6):5020-5050.
Díaz L1, Díaz-Muñoz M2, García-Gaytán AC3, Méndez I4.

1Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Tlalpan, Mexico City 14000, Mexico. lorenzadiaz at gmail.com.
2Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico. mdiaz at comunidad.unam.mx.
3Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico. acgarciag02 at gmail.com.
4Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Blvd. Juriquilla 3001, Querétaro 76230, Mexico. isabelcm at unam.mx.

Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways.
In the context of cancer, calcitriol

regulates the cell cycle,
induces apoptosis,
promotes cell differentiation and
acts as anti-inflammatory factor within the tumor microenvironment.

In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.

PMID: 26102214
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See also VitaminDWiki

Calcitriol category listing has 62 items along with related searches
Cancer category listing has 293 items along with related searches
Active vitamin D appears to treat cancer – more studies needed – June 2018
Active Vitamin D level should not be used for Prospective Studies of Cancer – Aug 2018

How active vitamin D (Calcitriol) deals with cancer – June 2015

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- Active Vitamin D level should not be used for Prospective Studies of Cancer – Aug 2018 Active vitamin D appears to treat cancer – more studies needed – June 2018 Vitamin D and receptor reduce carcinogenic effects of pollutants – July 2015

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