Mechanistic roles for calcium and vitamin D in the regulation of body weight
Obes Rev. 2012 Mar 2. doi: 10.1111/j.1467-789X.2012.00986.x.
M. J. Soares1 m.soares at curtin.edu.au
L. L. Murhadi1,
A. V. Kurpad2,
W. L. Chan She Ping-Delfos1,
L. S. Piers3
1 Program of Nutrition, School of Public Health, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
2 Department of Physiology, St John's National Academy of Health Sciences, Bangalore, India
3 Centre for Health & Society, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia
Article first published online: 2 MAR 2012
© 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity
Low intakes of calcium and inadequate vitamin D status often cluster with higher prevalence rates of obesity. Consequently, there has been much interest in the mechanisms by which calcium and vitamin D could regulate body weight and adiposity. This review has focused on randomized controlled trials (RCTs) that have manipulated these nutrients and studied pathways of energy balance.
Overall, there is consistent evidence that calcium and vitamin D increase whole body fat oxidation
after single and multiple meals, and that calcium promotes a modest energy loss through increased faecal fat excretion.
The evidence is equivocal for
- a greater diet-induced thermogenesis,
- increased lipolysis,
- suppression of key lipogenic enzymes,
- decreased hunger ratings or
- reduced energy/macronutrient intake.
Emerging evidence suggests a potential improvement in insulin sensitivity following vitamin D that would impinge on food intake and substrate oxidation.
However, the very few RCTs on supplemental vitamin D and energy balance have not explored postprandial avenues of the hormone's actions.
Future efforts in this area need to define the threshold intake of these nutrients that would maximize metabolic and gastrointestinal outcomes.
Such studies would provide a platform for endorsing the non-skeletal role of calcium and vitamin D in human pathophysiology.
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First two sentences of conclusion
It is our opinion that calcium with or without vitamin D modulates human energy metabolism.
The evidence is convincing that calcium increases fat oxidation after a single meal and over several meals of the day
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Vitamin D may need Calcium to fight obesity – Aug 2022
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Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
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The influence of Vitamin D and Calcium on fat and obesity – March 2014
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Obesity reduction with Calcium and vitamin D – controversy May 2012
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Adding Calcium and Vitamin D does not consistently reduce obesity – May 2012
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How might Calcium and Vitamin D cause weight loss – Mar 2012
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Weight loss and Vitamin D, Calcium, and Magnesium
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Black women lacking Calcium and Vitamin D weighed more – Aug 2011
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Middle-aged women gained weight if they did not drink fortified milk – Sept 2010
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More calcium and vitamin D resulted in weight loss – Sept 2010
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How Calcium might help reduce obesity – June 2010
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Calcium and vitamin D aided weight loss – RCT Sept 2010
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32 ng vitamin D and 500 mg of Calcium helped reduce weight by 5.6 kg – Sept 2010
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Calcium deficiency is a risk factor for overweight female teenagers April 2010
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Vitamin D and Calcium after Gastric bypass - April 2010
How might Calcium and Vitamin D cause weight loss – Mar 2012
8963 visitors, last modified 03 Aug, 2022,
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This page is in the following categories (# of items in each category)
This list is automatically updated
- Vitamin D may need Calcium to fight obesity – Aug 2022
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- The influence of Vitamin D and Calcium on fat and obesity – March 2014
- Obesity reduction with Calcium and vitamin D – controversy May 2012
- Adding Calcium and Vitamin D does not consistently reduce obesity – May 2012
- How might Calcium and Vitamin D cause weight loss – Mar 2012
- Weight loss and Vitamin D, Calcium, and Magnesium
- Black women lacking Calcium and Vitamin D weighed more – Aug 2011
- Middle-aged women gained weight if they did not drink fortified milk – Sept 2010
- More calcium and vitamin D resulted in weight loss – Sept 2010
- How Calcium might help reduce obesity – June 2010
- Calcium and vitamin D aided weight loss – RCT Sept 2010
- 32 ng vitamin D and 500 mg of Calcium helped reduce weight by 5.6 kg – Sept 2010
- Calcium deficiency is a risk factor for overweight female teenagers April 2010
- Vitamin D and Calcium after Gastric bypass - April 2010
8963 visitors, last modified 03 Aug, 2022, |