Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension.
Curr Protein Pept Sci. 2019 Aug 7. doi: 10.2174/1389203720666190807130504
Lin L1, Zhang L1, Li C1, Gai Z1, Li Y1.
Shandong University of Traditional Chinese Medicine, 250003 Ji-nan. China.
Hypertension category listing contains the following
see also
Overview Overview Hypertension and Vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies
- Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
- Hypertension risk reduced 4X if adequate level of Vitamin D – July 2024
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Magnesium reduces hypertension - FDA allows claim - Jan 2022
- Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
- High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
- Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
- Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018
Items in both categories Hypertension and Vitamin D Receptor are listed here:
- 4 Cardiovascular diseases are associated with little vitamin D getting to cells – May 2023
- Health problems running in family may be due to poor vitamin D (hypertension, VDR in this case) Sept 2022
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Preeclampsia reduced by Vitamin D - many studies
- Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019
- Helicobacter pylori infection and low vitamin D – several studies
- Hypertension, Vitamin D, and Vitamin D Receptor – Aug 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Hypertension, Vitamin D Receptor, and FokI gene – Editorial Aug 2014
Vitamin D, as a natural medicine, is known to regulate calcium and phosphate homeostasis. But abundant research has shown that vitamin D also plays a regulatory role in autoimmunity, inflammation, angiogenesis and vascular cell activity. Since the vitamin D receptor (VDR) is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention. Hypertension is a disease with high incidence and high cardiovascular risk. In recent years, both clinical trials and animal experiments have shown that vitamin D plays a regulatory role in decreasing blood pressure (BP) through inhibiting renin- angiotensin-aldosterone system activity, modulating function of vascular wall and reducing vascular oxidative stress.
A growing body of data suggest that vitamin D deficiency is associated with increased cardiovascular disease risk in hypertension, even short-term vitamin D deficiency may directly raise BP and promote target organ damage.
Due to the high correlation between vitamin D and hypertension, vitamin D supplementation therapy may be a new insight in the treatment of hypertension. The aim of this review will explore the mechanisms of the vitamin D and VDR in regulating the BP and protecting against the target organ damage.
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