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- Influence of vitamin D supplementation on immune function of healthy aging people: A pilot randomized controlled trial
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17 studies in both categories Immunity and Intervention
Influence of vitamin D supplementation on immune function of healthy aging people: A pilot randomized controlled trial
Front Nutr. 2022 Nov 1;9:1005786.doi: 10.3389/fnut.2022.1005786
Honglin Dong 1 2 , Viktorija Asmolovaite 1 , Sebastien Farnaud 2 , Derek Renshaw 2Objectives: This study aims to investigate the influence of vitamin D supplementation on immune function of healthy older adults.
Materials and methods: Designed as a randomized controlled trial, 21 participants (55-85 years) completed the study during May-November 2018 in Coventry, England. The participants were randomized into vitamin D or the control group, stratified by age, gender and body mass index. The vitamin D group (n = 12) took vitamin D3 tablets of 1,000 IU/day for 12 weeks plus vitamin D education leaflet, while the control group (n = 9) were only provided with the leaflet. At baseline, 6 and 12 weeks, plasma 25(OH)D levels and immunological and metabolic parameters including phagocytic activity of granulocytes and monocytes, tumor necrosis factor, interleukin 6, lymphocyte subsets and fasting blood glucose and lipid were measured. Dietary vitamin D intake was analyzed at baseline and week 12. Data were presented as mean ± SD. Two-way repeated measures ANOVA and independent t-test were used to analyze the data.
Results: At baseline, 42.9% of the participants were vitamin D deficiency (25(OH)D < 25 nmol/L), only 10% achieved a level of 25(OH)D > 50 nmol/L. Overweight/obese participants (n = 9) had significantly lower mean plasma 25(OH)D concentration (22.3 ± 8.7 nmol/L) than normal weight participants (48.1 ± 34.3 nmol/L) (P = 0.043). There was a significant increase in plasma 25(OH)D concentration in vitamin D group compared with that in control group (P = 0.002) during the intervention period. The plasma 25(OH)D concentration in vitamin D group was increased at 6 weeks (from 38.4 ± 37.0 nmol/L at baseline to 51.0 ± 38.2 nmol/L) with little change observed between 6 and 12 weeks (51.8 ± 36.4 nmol/L). The plasma creatinine concentration in vitamin D group was significantly decreased compared with the control group (P = 0.036) (79.8 ± 7.0 µmol/L at baseline vs 75.1 ± 5.4 µmol/L at week 12). No significant effect of vitamin D supplementation was determined on immunological parameters.
Conclusion: Vitamin D deficiency is common among the aging population in the UK even during the summertime. Vitamin D supplementation at 1,000 IU/day for 12 weeks significantly increased plasma 25(OH)D concentration but showed no effect on metabolic and immunological parameters except decreased plasma creatinine.
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17 studies in both categories Immunity and Intervention This list is automatically updated
- Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024
- Immune systems not improved with 1,000 IU of vitamin D daily (not a surprise) – Nov 2022
- Immune systems of overweight black women improved by monthly 60,000 IU Vitamin D – RCT Oct 2022
- 2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022
- Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021
- Sublingual Vitamin D sometimes is better than tablet – April 2020
- Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020
- Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019
- Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015
- T-cells increased with monthly doses of 140,000 IU vitamin D – April 2014
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013
- Middle ear infection (Otitis Media) and Vitamin D – many studies
- Viral infection reduced 90 percent with 2000 IU of vitamin D – Dec 2010
- Yet again - more than 10000 IU of vitamin D treats MS – July 2011
Immune systems not improved with 1,000 IU of vitamin D daily (not a surprise) – Nov 2022493 visitors, last modified 17 Nov, 2022, This page is in the following categories (# of items in each category)