Lyme disease and Vitamin D Receptor - many studies

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Lyme Disease Blocks Vitamin D Absorption by 80 X - video March 2024

Dr. Berg 6 minutes

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Lyme disease reduced Vitamin D Receptor by 8X to 50X - June 2019

Vitamin D Receptor - activation and deactivation- self-hacked June 2019

• Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and “dead” Borrelia reduces it by 8 times 63
  • This could explain why people develop autoimmune conditions after Lyme infection.

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Half of NE US Ticks have Lyme Disease - Jan 2025

TrialSiteNews

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Vitamin D Receptor - reduced by Lyme, easily restored by supplements

Chronic Lyme disease - includes VDR Feb 2019

The following text which is copied from the source, and has no active hyperlinks

Borrelia and the VDR
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.9)

Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment. Jun Sun 10)

Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is Borrelia burgdorferi. Live Borrelia burgdorferi reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates (“dead” Borrelia) reduced it by 8 times 11)

• 8) Human Tick-Borne Diseases in Australia., Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ, Front Cell Infect Microbiol9p3(2019)
• 9) Microbial manipulation of receptor crosstalk in innate immunity. Hajishengallis G, Lambris JD, Nat Rev Immunol11p187-200(2011 Mar)
• 10) Vitamin D and mucosal immune function. Sun J, Curr Opin Gastroenterolp(2010 Jul 15)  Download the PDF from VitaminDWiki
• 11) Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD, PLoS Pathog5pe1000444 (2009 May)  Download the PDF from VitaminDWiki

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Lyme Disease and Vitamin D Receptor Activators

Note: I do not have Lyme Disease, but have a poor vitamin D receptor
Nature's Essentials Resveratrol 500mg is an Amazon Resveratrol with high bio-availability which I have been taking

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Vitamin D Receptor category has the following

537 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 49 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (14 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (25 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (16 studies), Obesity (17 studies), Pregnancy (25 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (39 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

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Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk increase	Health Problem
50	Lyme Disease *
28	Leprosy - another says 3X
15	Chronic Heart Failure
15	Temporary hair loss
14.7	Childhood solid cancers
14	Hand, Foot, and Mouth disease
13	Sepsis
12	COVID Death
11	Metabolic Syndrome
9.6	Chronic Periodontitis    and smoke
8	Juvenile Rheumatoid Arthritis
8.0	Preterm birth
7.6	Crohn's disease
7.5	Respiratory Tract Infections
7.0	Lung Cancer
5.8	Low back pain in athletes
5	Respiratory Distress in preemies
5	Ulcerative Colitis
5	Coronary Artery Disease
5	Asthma Child see also 1.3, 2.0 and 3.7
4.6	Breast Cancer * 16.9 X another study
4.3	Severe COVID in kids
4.1	Vitiligo
4	Liver Cirhosis
4	Polycystic ovary syndrome
3.8	Lupus
3.6	Pneumonia - children
3.3	Pre-term birth
3.1	Colon Cancer survival
3	Multiple Sclerosis
3	Dengue
3	Waist size
3	Ischemic Stroke
3	Alzheimer’s 9X in women
3	Parkinson’s
3	Gestational Diabetes
2.9	Hand, Foot, Mouth Disease
2.8	Osteoporosis & COPD
2.7	Gastric Cancer
2.6	Lupus in children
2.5	Lumbar Disc Degeneration
2.4	Lung Cancer
2.3	Cardio
2.3	Autism
2.2	Juvenile idiopathic arthritis
2.1	Adolescent idiopathic scoliosis in Asians
2	Obesity
2	Diabetic Retinopathy
2	Parkinson's
2	Wheezing/Asthma see also 5X
2	Melanoma   Non-melanoma Skin Cancers
2	Myopia
2	Preeclampsia
1.9	Uterine Fibroids
1.9	Early tooth decay
1.8	Diabetic nephropathy
1.8	Sleep Apnea
1.6	Diabetes - Type I
1.6	Prostate Cancer while black
1.5	Diabetes -Type II
1.5	Gout
1.5	Pertussis
1.5	Obesity
1.4	Graves Disease
1.4	Rheumatoid arthritis
1.3	Hypertension
1.3	Childhood asthma see also 5X
1.3	Psoriasis in Caucasians
1.3	Tuberculosis

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Vitamin D Receptor Activators

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

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VitaminDWiki - Vitamin D Receptor deactivated by some health problems - many studies

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Have any of the following been found to prevent or treat Lyme Disease: Resveratrol Omega-3 Magnesium Zinc Quercetin Curcumin Berberine Butyrate Sulforaphane Ginger "Essential oils" "intense exercise"?

Perplexity (using CLAUDE 3.5 SONNET Oct 2024)

Based on the available research, here's what we know about the potential of those compounds for preventing or treating Lyme disease:
Resveratrol
Resveratrol, found in Japanese knotweed, has shown some promise:

• It has antimicrobial and anti-inflammatory properties that may help against Lyme disease  1 5
• A 2020 Johns Hopkins study found Japanese knotweed extract had greater activity against Borrelia burgdorferi (the Lyme bacteria) than some antibiotics   5
• Resveratrol appears safe at typical supplement doses, though it may have blood-thinning effects  5

Other Compounds

• Omega-3, magnesium, zinc, quercetin, curcumin: While these have general anti-inflammatory properties, there's no strong evidence specifically for Lyme disease prevention or treatment.
• Berberine: Some preliminary research suggests potential antimicrobial activity, but more studies are needed on its effects for Lyme disease.
• Butyrate, sulforaphane, ginger: No significant evidence was found regarding their use for Lyme disease.
• Essential oils: Oregano and thyme oils have shown some in vitro activity against B. burgdorferi, but clinical evidence is lacking   6

Exercise
While exercise may have general health benefits, there's no evidence that "intense exercise" specifically prevents or treats Lyme disease.
Key Points

• None of these compounds are proven treatments for Lyme disease.
• The most effective prevention methods remain avoiding tick bites and prompt tick removal  8
• Antibiotics are the standard treatment for diagnosed Lyme disease  8

It's important to consult with a healthcare provider for proper diagnosis and treatment of Lyme disease rather than relying solely on supplements or alternative remedies.

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20,000 hits as of April 2025 on VDR activators and Lyme Disease

Google Scholar

• Synergistic Antimicrobial Potential of Herbal and Essential Oil Compounds Against Borrelia burgdorferi and Other Bacterial Pathogens Jan 2025 Resveratrol occurs 9 times
• Characteristics of Clinics Offering Nontraditional Lyme Disease Therapies in Lyme Endemic States of the United States - Jan 2025 FREE PDF
  scores of therapies are described - costing $200 to $2,000. No mention of vitamin D receptor
• A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease March 2023 FREE PDF
• Lost in Lyme: The Therapeutic Use of Medicinal Plants in Supporting People with Lyme Disease Amazon book Google preview of book
• Recovery from Lyme Disease: The Integrative Medicine Guide to Diagnosing and Treating Tick-Borne Illness - 2021 Amazon
• The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses - July 2023 FREE PDF
• Plants supporting the treatment of Lyme disease - Sept 2023 FREE PDF
• Liberating Yourself from Lyme: An Integrative and Intuitive Guide to Healing Lyme Disease Jan 2021 Amazon Book   Google look inside of the book

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See also – Resveratrol improves health

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Lyme Disease - 500,000 Americans annually - more than Breast Cancer - Mercola Sept 2024

Mercola

• " There are more cases of Lyme disease than HIV and breast cancer combined.
  Of those 500,000, about 10% to 20% will stay sick for some period of time. We now believe that something on the order of 2 million people suffer the aftereffects of Lyme disease in the United States."
• The phrase "Vitamin D" does not occur once

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See also: Lyme and Vitamin D on the web

• In-depth coverage of Lyme disease - 2024 FREE PDF
• Five Common Nutritional Deficiencies In People With Chronic Lyme Disease April 2016
  • Vitamin D3, Magnesium, Zinc
• What's the deal with Vitamin D? LymeMD 2008
  • Appears that people trying to treat Lyme with just daily vitamin D get to toxic levels without any benefit
  • No mention of the Vitamin D Receptor which woul greatly reduce the amount of Vitamin D needed
  
  "According to the U.S. Centers for Disease Control and Prevention (CDC), an estimated 329,000 Americans are diagnosed with Lyme disease each year, although some data suggest it may actually be over 444,000.1 While exact numbers are difficult to ascertain, what is known is that the prevalence is rising."

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Lyme Disease rate increased 4X in 28 years

CDC

Possible reasons for increase include:
- lower D in population,
- increasing rate of poor Vitamin D Receptor,
- warmer climate
- more ticks

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Lyme Disease Is Baffling, Even to Experts

Atlantic Aug 2019
Took 16 years to get her problem correctly diagnosed

• "Reported cases increased almost fivefold from 1992 to 2017, and the Centers for Disease Control and Prevention estimates that annual incidences have risen to more than 300,000, and may even range above 400,000"
• "After 40 years in the public-health spotlight, Lyme disease still can’t be prevented by a vaccine; eludes reliable testing; and continues to pit patients against doctors, and researchers against one another."
• "A significant percentage of people who had Lyme symptoms and later tested positive for the disease had never gotten the rash. Others had many characteristic symptoms but tested negative for the infection, and entered treatment anyway. Most startling, a portion of patients who had been promptly and conclusively diagnosed with Lyme disease and treated with the standard course of doxycycline didn’t really get better."

Lyme Disease Map 2022

Map 2015

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It's Time to Get Serious about Tick-Borne Diseases - Scientific American Aug 2019

Scientific American Vitamin D NOT mentioned

• "Today another epidemic rages unchecked: the number of Lyme disease cases has doubled since 2004, for a total of over 400,000."
• "At least 10 to 20 percent stay sick for a year, with 5 percent still suffering 15 years later—this among patients receiving early treatment, who have the best outcomes"
• 67 Lyme Disease Clinical trials as of 2019
• "In 2017, mosquito-borne West Nile virus, which currently infects about 2,000 people annually in the U.S. received $42 million in support from the U.S. National Institutes of Health. Lyme disease, with 20 times the number of reported cases, got half as much, a figure that has changed little in a decade"

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Lyme Disease charts on the web

https://www.instagram.com/explore/search/keyword/?q=lyme%20diseqse

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