Phytochemicals (Quercetin, Resveratrol, Tumeric, etc.) plus Vitamin D – July 2023

Phytonutrients, also called phytochemicals or antioxidants,
   are compounds produced by plants that provide health benefits to the body

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Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases - July 2023

Int J Mol Sci . 2023 Jul 29;24(15):12167. doi: 10.3390/ijms241512167.
Kazuki Santa 1, Kenji Watanabe 2 3, Yoshio Kumazawa 4 5, Isao Nagaoka 5 6

Table of Contents

Grape Randomized Controlled Trials

A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one category of the chemical compounds mainly known as antioxidants, and recently, their anti-inflammatory effects in preventing chronic inflammation have received much attention. Here, we present a narrative review of the health-promotion and disease-prevention effects of phytochemicals,
including polyphenols, the latter of which are abundant in

• onions,
• oranges,
• tea,
• soybeans,
• turmeric,
• cacao, and
• grapes,
  • along with the synergetic effects of vitamin D.

A phenomenon currently gaining popularity in Japan is finding non-disease conditions, so-called ME-BYO (mibyou) and treating them before they develop into illnesses. In addition to lifestyle-related diseases such as metabolic syndrome and obesity, dementia and frailty, commonly found in the elderly, are included as underlying conditions. These conditions are typically induced by chronic inflammation and might result in multiple organ failure or cancer if left untreated. Maintaining gut microbiota is important for suppressing (recently increasing) intestinal disorders and for upregulating immunity. During the COVID-19 pandemic, the interest in phytochemicals and vitamin D for disease prevention increased, as viral and bacterial infection to the lung causes fatal inflammation, and chronic inflammation induces pulmonary fibrosis. Furthermore, sepsis is a disorder inducing severe organ failure by the infection of microbes, with a high mortality ratio in non-coronary ICUs. However, antimicrobial peptides (AMPs) working using natural immunity suppress sepsis at the early stage. The intake of phytochemicals and vitamin D enhances anti-inflammatory effects, upregulates immunity, and reduces the risk of chronic disorders by means of keeping healthy gut microbiota. Evidence acquired during the COVID-19 pandemic revealed that daily improvement and prevention of underlying conditions, in terms of lifestyle-related diseases, is very important because they increase the risk of infectious diseases. This narrative review discusses the importance of the intake of phytochemicals and vitamin D for a healthy lifestyle and the prevention of ME-BYO, non-disease conditions.
 Download the PDF from VitaminDWiki

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Phytochemicals are produced by plants to fight off fungi, bacteria, virus and consumption by animals.

https://en.wikipedia.org/wiki/Phytochemical
>50,000 phytochemicals are in many categories:
carotenoids and polyphenols
polyphenols: phenolic acids, flavonoids, stilbenes or lignans.
Flavonoids: anthocyanins, flavones, flavanones, isoflavones, and flavonols.
Flavanols: catechins, epicatechins, and proanthocyanidins.

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Chart of Phytochemicals

Science Direct 2016

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5 recent publications on Phytochemicals and Vitamin D

• Editorial: Rising stars in nutrition and inflammation - April 2023 10.3389/fnut.2023.1197351 FREE PDF
• Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D - July 2023 doi: 10.3390/ijms241512167 FREE PDF
• Healthy Diet, Grape Phytochemicals, and Vitamin D: Preventing Chronic Inflammation and Keeping Good Microbiota - 2023 : https://doi.org/10.2174/1871530323666221017151705
• Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies - June 2023 doi: 10.37349/etat.2023.00145 FREE PDF

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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

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11+ VitaminDWiki pages with QUERCETIN in the title

This list is automatically updated

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Quercetin for 12 weeks reduced fatty liver disease and reduced weight by 3.3 lbs - RCT July 2024

Quercetin intervention reduced hepatic fat deposition in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled crossover clinical trial
Am J Clin Nutr 2024 Jul 18:S0002-9165(24)00610-5. doi: 10.1016/j.ajcnut.2024.07.013
Full PDF is behind paywall, but portions are available on the website for free

Background
Non-alcoholic fatty liver disease (NAFLD) has become a growing public health problem worldwide. However, there is still lack of effective treatment strategies except lifestyle intervention.

Objective
To evaluate whether quercetin improves intrahepatic lipid content in patients with NAFLD.

Methods
In this randomized, double-blind, placebo-controlled crossover trial, 41 patients with NAFLD were randomly assigned to receive the quercetin (500 mg) or placebo capsules for 12 weeks, then switched interventions for another 12 weeks after a 4-week washout period. The primary outcome was intrahepatic lipid content evaluated by magnetic resonance imaging estimated proton density fat fraction. The secondary outcomes were liver function measurements, etc. Safety outcomes included blood routine.

Results
36 patients completed the trial. In ITT analyses, the quercetin intervention moderately decreased the intrahepatic lipid contents from 11.5±6.4% to 9.6±5.8%, compared with the placebo intervention (decreased by 0.1±2.6%, P=0.013 and adjusted P value is 0.028).
Body weight and body mass index were mildly reduced by 1.5±2.6 kg and 0.5±0.9 kg/m2 after the quercetin intervention (P<0.05 and both adjusted P values are 0.038), while the reductions were only 0.2±1.8 kg and 0.1±0.7 kg/m2 after the placebo intervention.
The intrahepatic lipid contents reductions were noticeably positively associated with the body weight losses after the quercetin and placebo interventions (r=0.557 and 0.412, P<0.001 and =0.007, respectively). Subgroup analyses found that the reduction of intrahepatic lipid contents in females (3.0±3.7%) was about twice as large as in males (1.4±2.5%) with a trend of statistically significance (P=0.113 and adjusted P value is 0.061). There were no significant differences in other secondary and safety outcomes. No adverse events associated with study intervention were found.

Conclusions
Twelve weeks treatment of quercetin could reduce intrahepatic lipid contents in patients with NAFLD, possibly explained by a slightly larger body weight loss in the quercetin group. The trial is registered at www.chictr.org.cn as ChiCTR2100047904.

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18+ VitaminDWiki pages with CURCUMIN in the title

This list is automatically updated

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Turmeric for Chronic Pain - Green Med Info 2022

Does your active lifestyle leave you aching and inflamed, wishing there was an alternative to dangerous NSAID drugs? Wish no more — turmeric's got your pain covered

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VitaminDWiki – Resveratrol improves health (Vitamin D receptor, etc.) - many studies contains

• The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
• Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
• Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
• Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
  • Quercetin and Curcumin in the case of Resveratrol

18 articles in both of the categories Resveratrol and Vitamin D Receptor

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VitaminDWiki – Vitamin D Receptor category contains

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

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Diseases associated with a poor Vitamin D Receptor

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk increase	Health Problem
50	Lyme Disease *
28	Leprosy - another says 3X
15	Chronic Heart Failure
15	Temporary hair loss
14.7	Childhood solid cancers
14	Hand, Foot, and Mouth disease
13	Sepsis
12	COVID Death
11	Metabolic Syndrome
9.6	Chronic Periodontitis    and smoke
8	Juvenile Rheumatoid Arthritis
8.0	Preterm birth
7.6	Crohn's disease
7.5	Respiratory Tract Infections
7.0	Lung Cancer
5.8	Low back pain in athletes
5	Respiratory Distress in preemies
5	Ulcerative Colitis
5	Coronary Artery Disease
5	Asthma Child see also 1.3, 2.0 and 3.7
4.6	Breast Cancer * 16.9 X another study
4.3	Severe COVID in kids
4.1	Vitiligo
4	Liver Cirhosis
4	Polycystic ovary syndrome
3.8	Lupus
3.6	Pneumonia - children
3.3	Pre-term birth
3.1	Colon Cancer survival
3	Multiple Sclerosis
3	Dengue
3	Waist size
3	Ischemic Stroke
3	Alzheimer’s 9X in women
3	Parkinson’s
3	Gestational Diabetes
2.9	Hand, Foot, Mouth Disease
2.8	Osteoporosis & COPD
2.7	Gastric Cancer
2.6	Lupus in children
2.5	Lumbar Disc Degeneration
2.4	Lung Cancer
2.3	Cardio
2.3	Autism
2.2	Juvenile idiopathic arthritis
2.1	Adolescent idiopathic scoliosis in Asians
2	Obesity
2	Diabetic Retinopathy
2	Parkinson's
2	Wheezing/Asthma see also 5X
2	Melanoma   Non-melanoma Skin Cancers
2	Myopia
2	Preeclampsia
1.9	Uterine Fibroids
1.9	Early tooth decay
1.8	Diabetic nephropathy
1.8	Sleep Apnea
1.6	Diabetes - Type I
1.6	Prostate Cancer while black
1.5	Diabetes -Type II
1.5	Gout
1.5	Pertussis
1.5	Obesity
1.4	Graves Disease
1.4	Rheumatoid arthritis
1.3	Hypertension
1.3	Childhood asthma see also 5X
1.3	Psoriasis in Caucasians
1.3	Tuberculosis

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Is BHT a phytochemical? It fights many enveloped viruses

A Quick Look at BHT - Aug 2023 substack

• "(A seemingly magic bullet for lipid-coated viruses with anti-aging properties)"

See Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011

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