Kidney disease and psoriasis: novel evidences beyond old concepts
Clinical Rheumatology, First online: 28 November 2015
Luca Visconti , Giuseppe Leonardi, Michele Buemi, Domenico Santoro, Valeria Cernaro, Carlo Alberto Ricciardi, Antonio Lacquaniti, Giuseppe Coppolino
88+ Disease associations: Disease 1 ==> Disease 2 (both associated with low vitamin D
- Statins ==> many diseases associated with low vitamin D update Jan 2012
- Parkinson, Alzheimer, Stroke ==>Hip fracture
- Parkinson's ==> Osteoporosis
- Low Grip Strength ==> Osteoporosis
- Immune System disease (CVID) ==> Osteoporosis
- COPD ==> Osteoporosis
- COPD ==> Bone Fracture 4.7 X
- COPD ==> osteoporosis, cardio., skeletal muscle, anemia, metabolic synd.
- HIV ==> Osteoporosis
- Cancer - Prostate ==> Osteoporosis
- Cancer - Prostate ==> Melanoma
- Cancer - Gynecological ==> Atherosclerosis
- Atopic Dermatitis ==> Osteopenia 1.8 X
- Alopecia Areata spot baldness ==> 5X higher risk of Lupus, vitiligo, metabolic syndrome
- Skin wrinkles ==> Fragile bones
- Depression ==> Fragile bones
- Depressed ==> Stroke 1.7X
- Depression ==> Heart Disease 1.4X
- Depression + Stroke ==> death 3X
- Depression ==> premature birth
96% increase in premature birth if anti-depressants in late pregnancy - Depression ==> Cognitive Decline
- Depression <==> Diabetes
- Acne ==> Depression
- Diabetes ==> Cognitive impairment
- Diabetes ==> Vertebral fracture in men only
- Diabetes ==> Rheumatoid Arthritis
- Diabetes ==> PCOS women
- PCOS ==> Diabetes
- Asthma ==> Diabetes 10X
- ear, nose, and throat infection ==> Diabetes 10X
- Periodontitis + Low Vit D ==> Diabetes 2.8X
- Obesity ==> Diabetes
- Diabetes ==> Pancreatic Cancer
- Diabetes ==> Cancers
- Diabetes ==> Alzheimer's
- Diabetes ==> TB?
- Diabetes (T1) ==> Multiple Sclerosis
- Diabetes ==> Parkinson's
- Smoking ==> weak bones
- Dental problems==> depression (pregnancy)
- Endometriosis ==> Coronary Heart Disease 3X
- Pregnancy ==> dental problems
- Pregnancy ==>Restless Legs
- No molar ==> 12X increase in Breast Cancer
- Obesity <==> Multiple Sclerosis
- Obesity ==> Cognitive Decline
- Obesity ==> Psorasis
- Obesity ==> Cancer
- Obesity ==> Migraine Headache 3X
- Aortic calcification==> Vertebral fracture
- Low vitamin D for various reasons ==> 9X Suicide
- Asthma ==> Heart Problems and death
- Kidney ==> Tooth loss 7X
- Kidney Disease ==> Osteoporosis 2014 full text
- Multiple Sclerosis ==> Asthma 3X
- Multiple Sclerosis ==> 2.6X increased Migrane Headache, web, full text online
- Multiple Sclerosis ==> Fractures 4X
- Multiple Sclerosis ==>>Fibromyalgia
- Multiple Sclerosis ==> Diabetes (T1)
- Psoriasis ==> Metabolic Syndrome on the web
- Psoriasis ==> Metabolic Syndrome
- Psoriasis ==> Kidney Disease
- Psoriasis ==> Heart problems
- Psoriasis ==> Diabetes
- Psoriasis==> Osteoporosis
- Psoriasis ==> Sleep Apnea
- Celiac Disease ==> Anemia, Psoriasis
- Celiac Disease ==> poor bones Aug 2014
- Intestinal Failure (gut) ==> Low Bone Mineral Density
- Chronic Pancreatitis ==>Painful bones
- Rheumatoid Arthritis ==> Cardiovascular
- Rheumatoid Arthritis ==>Psorasis 3.6X
- IBD ==> Cancer
- Stroke ==> Hip Fracture
- Stroke ==> Parkinson's Disease 2.4X
- Restless Legs <==> ADHD
- Schizophrenia ==> Depression
- Schizophrenia ==> Diabetes 3X
- Sleep Apnea ==>Fatty Liver disease
- Sleep Apnea ==>Gout
- Gout ==> Depression 3.8 X
- Hepatitis-C ==> Cancers - liver, prostate, ?
- Hepatitis -C ==> peripheral arterial disease 12X increase if > 65 years old
- Vitiligo ==> thyroid problems 2013
- Rickets ==> Autism
- Autism ==> Poor Bones
- Epilepsy ==> Osteoporosis
- Rickets ==> Breathing
- Lupus ==>preterm birth
Psoriasis is an immune-mediated inflammatory disease for a long time considered as a type of pathology characterized by an exclusive skin involvement. Recently it has been shown that patients affected by this disease have a higher risk of developing comorbidities such as
- cardiovascular diseases,
- arterial hypertension,
- diabetes mellitus, and
- metabolic syndrome.
Even the kidneys can be affected by psoriasis through three different mechanisms: immune-mediated renal damage, drug-related renal damage and chronic renal damage. Renal function should be monitored periodically to minimize the risk of renal adverse events.
Publisher wants $40 for the PDF
References
1.
Svedbom A, Dalén J, Mamolo C et al (2015) Increased cause-specific mortality in patients with mild and severe psoriasis: a population-based Swedish register study. Acta Derm Venereol 95:809–815PubMed
2.
Menter A, Griffiths CE, Tebbey PW, Horn EJ, Sterry W (2010) International Psoriasis Council. Exploring the association between cardiovascular and other disease-related risk factors in the psoriasis population: the need for increased understanding across the medical community. J Eur Acad Dermatol Venereol 24:1371–1377CrossRefPubMed
3.
Henseler T, Christophers E (1985) Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 13:450–456CrossRefPubMed
4.
Nestle FO, Kaplan DH, Barker J (2009) Psoriasis. N Engl J Med 361:496–509CrossRefPubMed
5.
Griffiths CE, Barker JN (2007) Pathogenesis and clinical features of psoriasis. Lancet 370:263–271CrossRefPubMed
6.
Paneni F, Osto E, Costantino S et al (2013) Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction. Circulation 127:1229–1240CrossRefPubMed
7.
Green MS, Prystowsky JH, Cohen SR, Cohen JI, Lebwohl MG (1996) Infectious complications of erythrodermic psoriasis. J Am Acad Dermatol 34:911–914CrossRefPubMed
8.
Menter A, Griffiths CE (2007) Current and future management of psoriasis. Lancet 370:272–284CrossRefPubMed
9.
Cassano N, Vestita M, Panaro M, Carbonara M, Vena GA (2011) Renal function in psoriasis patients. Eur J Dermatol 21:264–265PubMed
10.
Chiu HY, Huang HL, Li CH et al (2015) Increased risk of glomerulonephritis and chronic kidney disease in relation to the severity of psoriasis, concomitant medication, and comorbidity: a nationwide population-based cohort study. Br J Dermatol 173:146–154CrossRefPubMed
11.
Singh NP, Prakash A, Kubba S et al (2005) Psoriatic nephropathy does an entity exist? Ren Fail 27:123–127PubMed
12.
Zadrazil J, Tichý T, Horák P et al (2006) IgA nephropathy associated with psoriasis vulgaris: a contribution to the entity of “psoriatic nephropathy”. J Nephrol 19:382–386PubMed
13.
Sakemi T, Hayashida R, Ikeda Y, Baba N, Nishihara G, Kohda H (1996) Membranous glomerulonephropathy associated with psoriasis vulgaris. Nephron 72:351–352CrossRefPubMed
14.
Guilhou JJ, Clot J, Meynadier J, Lapinski H (1976) Immunological aspects of psoriasis. I. Immunoglobulins and anti-IgG factors. Br J Dermatol 94:501–507CrossRefPubMed
15.
Hall RP, Peck GL, Lawley TJ (1983) Circulating IgA immune complexes in patients with psoriasis. J Investig Dermatol 80:465–468CrossRefPubMed
16.
Lindqvist U, Rudsander A, Boström A, Nilsson B, Michaëlsson G (2002) IgA antibodies to gliadin and coeliac disease in psoriatic arthritis. Rheumatology 41:31–37CrossRefPubMed
17.
Damasiewicz-Bodzek A, Wielkoszyński T (2012) Advanced protein glycation in psoriasis. J Eur Acad Dermatol Venereol 26:172–179CrossRefPubMed
18.
Coppolino G, Bolignano D, Campo S, Loddo S, Teti D, Buemi M (2008) Circulating progenitor cells after cold pressor test in hypertensive and uremic patients. Hypertens Res 31:717–724CrossRefPubMed
19.
Wittenberg GP, Oursler JR, Peters MS (1995) Secondary amyloidosis complicating psoriasis. J Am Acad Dermatol 32:465–468CrossRefPubMed
20.
Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA (1983) The pharmacology and clinical use of methotrexate. N Engl J Med 309:1094–1104CrossRefPubMed
21.
Widemann BC, Adamson PC (2006) Understanding and managing methotrexate nephrotoxicity. Oncologist 11:694–703CrossRefPubMed
22.
Buemi M, Floccari F, Costa C et al (2006) Dialysis-related genotoxicity: sister chromatid exchanges and DNA lesions in T and B lymphocytes of uremic patients. Genomic damage in patients on hemodiafiltration. Blood Purif 24:569–574CrossRefPubMed
23.
Furst DE, Herman RA, Koehnke R et al (1990) Effect of aspirin and sulindac on methotrexate clearance. J Pharm Sci 79:782–786CrossRefPubMed
24.
Myers BD, Ross J, Newton L, Luetscher J, Perlroth M (1984) Cyclosporine-associated chronic nephropathy. N Engl J Med 311:699–705CrossRefPubMed
25.
Burdmann EA, Andoh TF, Yu L, Bennett WM (2003) Cyclosporine nephrotoxicity. Semin Nephrol 23:465–476CrossRefPubMed
26.
Wolf G, Killen PD, Neilson EG (1990) Cyclosporin A stimulates transcription and procollagen secretion in tubulointerstitial fibroblasts and proximal tubular cells. J Am Soc Nephrol 1:918–922PubMed
27.
Roodnat JI, Christiaans MH, Nugteren-Huying WM et al (1989) Acute kidney insufficiency in the treatment of psoriasis using fumaric esters. Schweiz Med Wochenschr 119:826–830PubMed
28.
Raschka C, Koch HJ (1999) Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage. Hum Exp Toxicol 18:738–739CrossRefPubMed
29.
Lee MR, Cooper AJ (2006) Biologic agents in psoriasis. Australas J Dermatol 47:217–229CrossRefPubMed
30.
Melgaço SS, Silva GB Jr, Dantas AM et al (2013) Evaluation of renal function in patients with psoriasis using immunobiologicals. An Bras Dermatol 88:667–669PubMedCentralCrossRefPubMed
31.
Little MA, Bhangal G, Smyth CL et al (2006) Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis. J Am Soc Nephrol 17:160–169CrossRefPubMed
32.
Yahya TM, Dhanyamraju S, Harrington TM, Prichard JW (2013) Spontaneous resolution of lupus nephritis following withdrawal of etanercept. Ann Clin Lab Sci 43:447–449PubMed
33.
Menè P, Franeta AJ, Conti G et al (2010) Extracapillary glomerulonephritis during etanercept treatment for juvenile psoriatic arthritis. Clin Exp Rheumatol 28:91–93PubMed
34.
Chin G, Luxton G, Harvey JM (2005) Infliximab and nephrotic syndrome. Nephrol Dial Transplant 20:2824–2826CrossRefPubMed
35.
Davidovici BB, Sattar N, Prinz J et al (2010) Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J Investig Dermatol 130:1785–1796CrossRefPubMed
36.
Wan J, Wang S, Haynes K, Denburg MR, Shin DB, Gelfand JM (2013) Risk of moderate to advanced kidney disease in patients with psoriasis: population-based cohort study. BMJ 347:f5961PubMedCentralCrossRefPubMed
37.
Chi CC, Wang J, Chen YF, Wang SH, Chen FL, Tung TH (2015) Risk of incident chronic kidney disease and end-stage renal disease in patients with psoriasis: a nationwide population-based cohort study. J Dermatol Sci 78:232–238CrossRefPubMed
38.
Gisondi P, Rossini M, Di Cesare A et al (2012) Vitamin D status in patients with chronic plaque psoriasis. Br J Dermatol 166:505–510CrossRefPubMed