- Immune Response: A Missed Opportunity Between Vitamin D and Radiotherapy
- As with Chemotherapy, may need to reduce the amount of radiation therapy when Vitamin D levels are increased
- Loading Dose of Vitamin D category has the following
- TOP articles in Loading Dose of Vitamin D
- VitaminDWiki - Radiation and Vitamin D - many studies
Immune Response: A Missed Opportunity Between Vitamin D and Radiotherapy
Review Front Cell Dev Biol . 2021 Apr 13;9:646981. doi: 10.3389/fcell.2021.646981
Xinyue Yu 1, Baocai Liu 1, Ning Zhang 1, Qian Wang 1, Guanghui Cheng 1
As with Chemotherapy, may need to reduce the amount of radiation therapy when Vitamin D levels are increased__
click on chart for details
- Vitamin D prevents and treats cancer in many ways – May 2021
- 3X less pelvic inflammation from cancer radiation if high level of vitamin D – Feb 2015
- Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021
Note: To be of a benefit, Vitamin D levels need to be raised BEFORE radiation therapy
A large vitamin D loading dose can restore Vitamin D levels in 10 days
Loading Dose of Vitamin D category has the following
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses
TOP articles in Loading Dose of Vitamin D
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
- Large dose Vitamin D before surgery was found to help by 35 studies
- Vitamin D is needed before most surgeries – many studies and RCTs
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
- Take lots of Vitamin D at first signs of COVID
- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
- Can get 50,000 IU Vitamin D anywhere on the globe
Download the PDF from VitaminDWiki
Radiotherapy (RT) is a mainstay treatment in several types of cancer and acts by mediating various forms of cancer cell death, although it is still a large challenge to enhance therapy efficacy. Radiation resistance represents the main cause of cancer progression, therefore, overcoming treatment resistance is now the greatest challenge for clinicians. Increasing evidence indicates that immune response plays a role in reprogramming the radiation-induced tumor microenvironment (TME). Intriguingly, radiation-induced immunosuppression possibly overwhelms the ability of immune system to ablate tumor cells. This induces an immune equilibrium, which, we hypothesize, is an opportunity for radiosensitizers to make actions.
Vitamin D has been reported to act in synergistic with RT by potentiating antiproliferative effect induced by therapeutics. Additionally, vitamin D can also regulate the TME and may even lead to immunostimulation by blocking immunosuppression following radiation. Previous reviews have focused on vitamin D metabolism and epidemiological trials, however, the synergistic effect of vitamin D and existing therapies remains unknown.
This review summarizes vitamin D mediated radiosensitization, radiation immunity, and vitamin D-regulated TME, which may contribute to more successful vitamin D-adjuvant radiotherapy.
VitaminDWiki - Radiation and Vitamin D - many studies
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