Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022

---

Nuclear Magnetic Resonance-Measured Ionized Magnesium Is Inversely Associated with Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study

Nutrients 2022, 14(9), 1792; https://doi.org/10.3390/nu14091792
by Erwin Garcia 1,†ORCID,Irina Shalaurova 1,†,Steven P. Matyus 1,Joelle C. Schutten 2ORCID,Stephan J. L. Bakker 2ORCID,Robin P. F. Dullaart 3ORCID andMargery A. Connelly 1,*ORCID
1 Laboratory Corporation of America Holdings (Labcorp), Morrisville, NC 27560, USA
2 Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
3 Department of Internal Medicine, Division of Endocrinology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands

The aims were to optimize a nuclear magnetic resonance (NMR)-based assay for quantifying ionized or free magnesium and investigate its association with type 2 diabetes (T2D). A high-throughput, ionized magnesium assay was optimized and evaluated. Plasma magnesium was quantified, and associations with T2D were ascertained in Insulin Resistance Atherosclerosis Study (IRAS) participants. Coefficients of variation for the ionized magnesium assay ranged from 0.7–1.5% for intra-assay and 4.2–4.7% for inter-assay precision. In IRAS (n = 1342), ionized magnesium was significantly lower in subjects with prediabetes and T2D than in normoglycemic subjects, and lower in participants with T2D than those with prediabetes (p < 0.0001). Cross-sectional regression analyses revealed that magnesium was associated with T2D at baseline in models adjusted for multiple clinical risk factors (p = 0.032).

This association appeared to be modified by sex, in such a way that the associations were present in women (OR = 0.54 (95% CI 0.37–0.79), p = 0.0015) and not in men (OR = 0.98 (95% CI 0.71–1.35), p = 0.90).

Longitudinal regression analyses revealed an inverse association between magnesium and future T2D in the total population (p = 0.035) that was attenuated by LP-IR (p = 0.22). No interactions were detected between magnesium and age, race, BMI, glucose, insulin, triglycerides, or LPIR for the prospective association with future T2D. However, a significant interaction between magnesium and sex was present, now with a trend for an association in men (OR = 0.75 (95% CI 0.55–1.02), p = 0.065 and absence of an association in women (OR = 1.01 (0.76–1.33), p = 0.97).

Conclusions: lower ionized magnesium, as measured by an NMR-based assay optimized for accuracy and precision, was associated cross-sectionally with T2D at baseline and longitudinally with incident T2D in IRAS
 Download the PDF from VitaminDWiki

---

Review of study by Grassrootshealth (includes summary chart)

Magnesium Status May Be a Predictor of Type 2 Diabetes

GRH sells many types of home tests: Magnesium as well as Vitamin D, Omega-3. etc.
Simple Magnesium (RBC) + Vitamin D together cost $145
Mg tests differences

---

VitaminDWiki - Relationships between Magnesium and health problems

Bone 16,  Cardiovascular 17,   Diabetes 29. Depression 14,  Obesity 11,   Omega-3 39,  Zinc 24,  Pregnancy 11,  Headache 11,   Virus 26,   Calcium 28   Virus 26   Mortality 9   Hypertension 13   Inflammation 4   Pain 7 etc.

---

VitaminDWiki - 29 studies in both categories Magnesium and Diabetes

This list is automatically updated