Respiratory tract microbiome and breathing problems

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PubMed – 238 studies of Lung Microbiome in 2017

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See also VitaminDWiki

• 360X more bacterial than human genes in the body – June 2012 not just the gut
• Antibiotics, probiotics category listing has 93 items along with related searches
• Gut microbiome massively changed by weekly vitamin D – July 2015
• Microbiome improvement by probiotics can be augmented with phages (gut, etc.)

Inhaled Vitamin D

• The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
• Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017
• Inhaled vitamin D helped lungs of new-born (rats) – Dec 2016

Breathing category starts with the following

451 items in Breathing category

Breathing-related Overviews at VitaminDWiki:
Allergy   Lung Cancer   TB   Asthma  Influenza  Colds and flu
Pneumonia   Respiratory infections   COPD   Air Polution   Smoking   Cystic Fibrosis

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See also web

• A Specifically Designed Multispecies Probiotic Supplement Relieves Seasonal Allergic Rhinitis Symptoms May 2018
  Ecologic® AllergyCare twice daily. 63% had meaningful reduction in allergies in 4 weeks, DOI: 10.1089/acm.2017.0342
• Probiotic to improve Quality of life - RCT March 2017 free PDF
• Do probiotics have a role in the treatment of allergic rhinitis? A comprehensive systematic review and meta-analysis Sept 2016
  Yes - it does help. Improving results over the years as the best probiotic strains are found
   Download the PDF from VitaminDWiki
• Nasal probitics on Amazon   28 products got high ratings as of June 2018

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Bacteria in Your Lungs? New Microbiome Study Shows How They Get There - Feb 2017

link

• “Bacteria in the lungs may play a major role in disease — and health. Researchers have just mapped where the bacteria are and how they arrived, paving the way for more discoveries about the lung microbiome.”
• “… evidence that most of the bacteria in the lungs of healthy people got there by way of microaspiration. In other words, they ride in on tiny droplets of saliva that made it from the microbe-filled mouth to the lungs”
• “Unlike the gut, healthy lungs are an inhospitable environment for bacteria, with little nutrition and constant surveillance by the immune system.”
• “We are probably all aspirating small amounts of bacteria constantly, and so long as our immune system is intact, they rarely make us sick.”
• “He and colleagues have already found evidence that the lungs are filled with gut microbes in critically ill patients.”

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Discovery of Gut Bacteria in Critically Ill Lungs May Change ICU Care= July 2016

link

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Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome - July 2016

link  PDF $9 Readcube

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The Role of the Bacterial Microbiome in Lung Disease – June 2013

Link

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Understanding Microbiome Effect on Immune Checkpoint Inhibition in Lung Cancer: Placing the Puzzle Pieces Together – May 2018

Link
Over the past couple of years, human microbiome has received increasing attention as a regulator and predictor of response to the therapies of various diseases. It is speculated that manipulating gut microbiome can modify response to cancer immunotherapies as well. Through this review, we have critically analyzed our current understanding of gut microbiome as a modulator of immunotherapies in lung cancer, explained conflicting data, evaluated current gaps and extrapolated our present knowledge to generate directions for future investigations.

PMID: 29781826 DOI: 10.1097/CJI.0000000000000232

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The microbiome and the lung.– Aug 2014

Ann Am Thorac Soc. 2014 Aug;11 Suppl 4:S227-32. doi: 10.1513/AnnalsATS.201402-052PL.
Cui L1, Morris A, Huang L, Beck JM, Twigg HL 3rd, von Mutius E, Ghedin E.

Investigation of the human microbiome has become an important field of research facilitated by advances in sequencing technologies. The lung, which is one of the latest body sites being explored for the characterization of human-associated microbial communities, has a microbiome that is suspected to play a substantial role in health and disease. In this review, we provide an overview of the basics of microbiome studies. Challenges in the study of the lung microbiome are highlighted, and further attention is called to the optimization and standardization of methodologies to explore the role of the lung microbiome in health and disease. We also provide examples of lung microbial communities associated with disease or infection status and discuss the role of fungal species in the lung. Finally, we review studies demonstrating that the environmental microbiome can influence lung health and disease, such as the finding that the diversity of microbial exposure correlates inversely with the development of childhood asthma.
 Download the PDF from VitaminDWiki

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Lung microbiome in healthy and diseased individuals – July 2017

link
 Download the PDF from VitaminDWiki

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Bacterial Topography of the Healthy Human Lower Respiratory Tract – Jan 2017

 Download the PDF from VitaminDWiki

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The cystic fibrosis lung microbiome - Jan 2014

Link doi: 10.1513/AnnalsATS.201306-159MG.

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Lung microbiota – Wikipedia May 2018

Link

• “The microbial communities are highly variable in particular individuals and compose of about 140 distinct families. The bronchial tree for instance contains a mean of 2000 bacterial genomes per cm2 surface”
• “Changes in microbial community composition seem to play a role in progression of such pulmonary disorders as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis”

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List of human microbiota – Wikipedia – May 2018

1 Whole-body distributed
2 Natural cavities
3 Skin
3.1 Hair follicles
4 External ear
5 Mucous membranes
6 Eye
7 Gastrointestinal tract
8 Respiratory tract
9 Urogenital tract
10 Vagina
11 Placenta
12 Uterus
13 Ovarian follicle
14 Male reproductive tract