Risk of Prostate Cancer 3X higher if very low Magnesium – Feb 2025

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Association between magnesium depletion score and prostate cancer

Hongyang Gong, Xiaomei Lin & Shaoqun
Scientific Reports volume 15, Article number: 4801 https://doi.org/10.1038/s41598-025-89506-y

Model 4 adjusts for” age, education level, marital, PIR, race, obesity, smoking, physical activity, hypertension, diabetes, and high cholesterol.

The Magnesium Depletion Score (MDS) is a practical tool used to assess magnesium deficiency. Studies have indicated that MDS is associated with various urological conditions, such as kidney stones and the prognosis of chronic kidney disease. However, the relationship between MDS and prostate cancer (PCa) remains unclear. Therefore, this study aims to investigate the association between MDS and PCa. This study conducted a cross-sectional analysis of 16,043 participants from the 2005–2018 NHANES database. Subgroup analysis, restricted cubic splines (RCS), and multivariable logistic regression were employed to examine the association between MDS and the prevalence of PCa. A total of 16,043 participants were included in this study, of whom 511 had PCa. After adjusting for all variables using multivariable logistic regression, each 1-unit increase in MDS was associated with a 26% higher prevalence of PCa (OR = 1.26, 95% CI: 1.05, 1.50).
Additionally, compared to an MDS of 0, an MDS of 3 or higher was associated with a 3.04-fold increase in PCa prevalence (OR = 3.04, 95% CI: 1.53, 6.01). RCS analysis demonstrated a significant linear positive correlation between MDS and PCa prevalence. Subgroup analysis indicated that the positive association between MDS and PCa was generally consistent across different population groups. This study indicates a significant association between MDS and the risk of PCa, with higher MDS linked to an increased prevalence of PCa. These findings highlight the potential role of MDS in PCa. Further research is needed to determine whether a causal relationship exists between MDS and PCa, which would help assess the appropriateness of potential interventions.
 Download the PDF from VitaminDWiki

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VitaminDWiki - Magnesium Depletion Score predicts increased risk of various health problems

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VitaminDWiki - Overview Prostate Cancer and Vitamin D contains:

All items in category Prostate Cancer and Vitamin D 105 items

Examples

• Overview Prostate Cancer and Vitamin D
• Prostate Cancer long term survival 1.7 X more likely if high level of vitamin D – Jan 2016
• High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016
• Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
  • Probably better than 40% reduction if 40 ng of Vitamin D and minimize Calcium
• Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
  • Probably better than 40% reduction if 40 ng of Vitamin D and improve Receptor activation (8 ways)
• Low-Grade Prostate Cancer 70 percent less likely to progress if good level of Omega-3 – June 2018
  • Might prevent Prostate Cancer with Omega-3 and Vitamin D
• Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021
• The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019
• Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022
• Can take 40,000 IU of vitamin D daily before prostate cancer surgery – RCT March 2013

The Meta-analysis of Prostate Cancer

Vitamin D prevents/treats Prostate Cancer much better when there is not excess Calcium
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 prevention
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015 treatment
7X increase in stage IV Prostate Cancer survival when vitamin D greater than 32 ng – May 2013
Never too late to have vitamin D - loading dose is great before Prostate Surgery

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VitaminDWiki – Magnesium and Vitamin D contains

373 items in category, see also

• Overview Magnesium and vitamin D
• Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023
• The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023
• Magnesium deficiency – causes and symptoms – May 2016
• Magnesium Depletion Score predicts increased risk of various health problems
• Vitamins and Metals needed by the Immune System – Jan 2020
• Magnesium: intake decreased, difficult to measure in body – Sept 2018
• Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
• Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
• Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
• Magnesium is great for health, topical much faster than oral, MgCl2 is the best – 2019
• Magnesium is important for health but levels are low – July 2018
• How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
• Magnesium etc. reduced in crops (must supplement) – 2009

Magnesium and Vitamin D

• Intracellular Magnesium and Vitamin D - a few studies
• Vitamin D and Magnesium need each other - many studies
• Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
• 500 mg of Magnesium for 8 weeks increased Vitamin D by 4 ng – July 2020
• Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018
• Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
• Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
• Vitamin D Cofactors in a nutshell
• Magnesium and Vitamin D - similar, different and synergistic

12+ VitaminDWiki Magnesium pages have MANY STUDIES in the title
The list is automatically updated

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VitaminDWiki – Overview Magnesium and vitamin D has a Venn diagram

	Magnesium	not Magnesium
Vitamin D	Magnesium or Vitamin D Aging, Amyotrophic Lateral Sclerosis, Alzheimer's Disease; Asthma, Attention Deficit Disorder, Autism, Cancer, Cerebrovascular, Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis, Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones, Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis, Peripheral vascular disease; Pregnancy-related problems, Rheumatoid Arthritis, Sports-related problems,	Vitamin D only Acne, Allergy, Autoimmune, Bone, Breathing, Celiac, Cognition, Colds and Flu, Cystic Fibrosis, Dental, Fertility, hyperparathyroid, Immunity, Kidney, Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson, Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid, Tuberculosis, Vision, Hair, Skin, Sports
Not Vitamin D	Magnesium only Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy, Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation, Cramps, Fluoride Toxicity, Head Injuries, Central Nervous System Injuries, Magnesium Deficiency; Menopause, Mitral Valve Prolapse, Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS, Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence	Neither ALL OTHER DISEASES

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Associations between Magnesium and other categories

Omega-3 33,  Diabetes 27,  Vitamin K 27,  Calcium 26,  Virus 25,  Zinc 24,  Cardiovascular 17,  Bone - Health 15,  Vitamin B12 15,  Iron 14,  Depression 14,  Supplement 12,  Vitamin C 11,  Obesity 11,  Hypertension 11,  Headache 10,  Boron 10,  Pregnancy 10,  Metabolic Syndrome 9,  Intervention 9,  Mortality and D 8,  Iodine 8,  Seniors 8,  Deficiency of Vitamin D 8,  Books,   videos on Vitamin D 7,  Pain - chronic 7,  Resveratrol 7,  Interactions with Vitamin D 6,  Vitamin D and Vitamin A 6,  Cognitive 6,  Falls and Fractures 5,  Trauma and surgery 5,  Kidney 5,  Women 5,  Osteoporosis 4,  Breathing 4,  Infant-Child 4,  ADHD 4,  Cancer - Breast 4,  Cancer - Colon 4,  Predict Vitamin D 4,  Associations 4,  Off Topic 4,  Curcumin 4 (Nov 2023)