The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital
European Journal of Pediatrics (2021) https://doi.org/10.1007/s00431-021-04030-1
Elvan Bayramoğlu, Gülşen Akkoç, Ayşe Ağbaş, Özlem Akgün, Kamer Yurdakul, Hatice Nilgün Selçuk Duru & Murat Elevli
Note: No COVID-19 vaccine is expected to be available to children until 2022
Consider increasing vitamin D levels in children so as to reduce COVID-19 risk until vaccine is available
Items in both categories Virus and Infant/Child:
- Pfizer COVID vaccinations resulted in altering immune systems (increased IgG4 ) – Aug 2024
- FDA study of 4 million children found 2 COVID-19 vaccination red flags, but continue to push boosters – May 2024
- Children in hospital: those with COVID had lower Vitamin D, Iron, etc. – April 2024
- US has the most vaccinations before age 1 and the most deaths - March 2024
- 18,000 schoolchildren in Canada to be suspended for not being vaccinated - Feb 2024
- COVID Vaccinated Children 1.25 X More Likely to Be Hospitalized for Respiratory Illness - CDC Jan 2024
- France has injected 200,000 infants with RSV vaccine, based on no long-term data - Here we go again - Dec 2023
- Brazil mandates COVID-19 vaccine for children - Nov 2023
- Doctors in NY cannot opt out of COVID boosters for children - Oct 2023
- Infants getting lots of vaccinations are 2X more likely to die - July 2023
- COVID, Long-COVID and Vitamin D in children - Review April 2023
- Multisystem Inflammatory Syndrome of COVID in Children 3X more likely if low Vitamin D – Feb 2023
- PICU layoffs due to pandemic lulls, but children are now getting 3 years of viral infection all at once – Oct 2022
- COVID 5.5 X more likely to be severe if low Vitamin D (children in this case) – Oct 2022
- Tripledemic: Flu, COVID, and RSV (all fought by Vitamin D) - Oct 2022
- CDC advised to recommended annual COVID vaccination of all children over 6 months old – Oct 20, 2022
- 6X increase in excess deaths of children since vaccinations were started - Oct 2022
- Early puberty during pandemic (low vitamin D) - several studies
- COVID kids were more likely to have a poor VDR (4.3 X), than low Vitamin D (2.6 X) – Sept 2022
- Recent increases in pediatric endocrine problems may be decreased by Vitamin D – Aug 2022
- COVID children helped by Vitamin D, trial terminated: unethical to not give Vitamin D to all: – RCT July 2022
- Increase in children with low vitamin D and with tibia fractures during COVID – June 2022
- 28,859 deaths and 238,412 serious injuries due to vaccines, how many more when add ages 0.5 - 5 – June 2022
- Pandemic Vitamin D levels dropped by 3.3 ng (perhaps less D, more health problems) – May 2022
- Problems after childhood vaccinations - many studies
- FDA approved 5-11 vaccine booster (based tiny unpublished study without asking advisory panel) May 2022
- Remdesivir approved to treat COVID in Infants, yet Vitamin D is 3000 X more cost effective and widely used - April 2022
- Risk factors for severe COVID in children are all related to low vitamin D (same as adults) - April 2022
- Hepatitis normally rare in children: huge increase after lockdown (Adenovirus, low Vitamin D) - April 2022
- Children with higher Vitamin D had less severe COVID (no surprise) – April 2022
- Children have less severe COVID, but just as much long-haul as adults - April 2022
- Croup (due to viruses) has surged with Omicron - March 2022
- COVID children with multisystem inflammatory syndrome have less than 10 ng of vitamin D – March 2022
- 16,000 Physicians and Scientists Agree Kids Shouldn’t Get COVID Vaccine - Dec 15, 2021
- Younger are much less likely to die of COVID than elderly (posters) - Nov 2021
- COVID Vaccination trial for kids: 11 red flags - Oct 25, 2021
- Children and COVID - many studies
- 8 of 10 pediatric COVID-19 infections were Vitamin D deficient (49 patients) – May 2021
- Severe pediatric COVID 5.5 more likely if low vitamin D (review of 6 studies) -July 2021
- Sudden Infant Deaths (SIDS) soon after vaccination - several studies
- Hospitalized children with COVID-19 and inflammation had lower vitamin D – March 2021
- Severe childhood COVID-19 associated with Vitamin D deficiency (hospital in Turkey) – March 2021
- Vitamin D might reduce Multisystem Inflammatory Syndrome in children – March 2021
- 87 percent of children with COVID–19 had low vitamin D (small study) – Feb 2021
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- 13 possible reasons why COVID-19 is less severe in children – Dec 1, 2020
- Vitamin D associated with reduced COVID-19 risks in children - Grassroots Nov 2020
- Children with low vitamin D far more likely to hospitalized with COVID-19 – Oct 2020
- Respiratory viral infection (RSV) and low vitamin D - many studies
- Increased weight in children 8X more likely for each unit increase in adenovirus (if ignore Vitamin D) – Nov 2019
COVID-19 treated by Vitamin D - studies, reports, videos
As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Vitamin D has an immunomodulating property that regulates the inflammatory response. In this study, the aim was to evaluate the relationship between vitamin D levels and clinical severity and inflammation markers in children and adolescents with COVID-19. The clinical and laboratory records of 103 pediatric cases with COVID-19, whose vitamin D levels had been measured, were retrospectively reviewed. The cases were divided into groups according to their clinical severity (asymptomatic, mild, and moderate-to-severe) and vitamin D levels. The moderate-to-severe clinical group had significantly higher inflammation markers (CRP, procalcitonin, fibrinogen, D-dimer) and a lower lymphocyte count compared to both the mild and asymptomatic groups. The 25 OH vitamin D levels were also significantly lower (p < 0.001), and the ratio of vitamin D deficiency was 70.6% in the moderate-to-severe group. The vitamin D–deficient group had a significantly higher age and fibrinogen levels while also having a lower lymphocyte count compared to the insufficient and normal groups. The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = −0.496, p = <0.001), CRP (r = −0.309, p = 0.002) and fibrinogen levels (r = −0.381, p = <0.001). In a logistic regression analysis, vitamin D deficiency, D-dimer, and fibrinogen levels on admission were independent predictors of severe clinical course.
Conclusion: This study revealed an association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric COVID-19 cases. Prophylactic vitamin D supplementation may be considered, especially in the adolescent age group.
What is Known:
- The pathology of COVID-19 involves a complex interaction between the SARS-CoV-2 and the immune system. Hyperinflammation/cytokine storm is held responsible for the severity of the disease.
- Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection.
What is New:
- Clinically more severe group had significantly lower vit D levels and significantly higher inflammation markers.
- Lower 25 OH vit D levels were associated with higher inflammation markers, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response.
There have actually been
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