- Safety Profile of Vitamin D Supplements Using Real- World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis
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Safety Profile of Vitamin D Supplements Using Real- World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis
This preprint by German authors uses UK data
doi: 10.20944/preprints202406.1027.v1
Sha Sha 1,2, Miriam Degen 1,2, Tomislav Vlaski 1,2, Ziwen Fan 1, Hermann Brenner I3,4,* and Ben Schottker 1
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
- Faculty of Medicine, University of Heidelberg, 69115 Heidelberg, Germany
- Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany
- German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
* Correspondence: h.brenner at dkfz.de; +49-6221-42-1300, Fax: +49-6221-42-1302
1.5% of those in the UK have > 100 nmol (40 ng) of Vitamin D
Background: Potential calcium-related adverse events of vitamin D supplement use have not been addressed in large-scale, real-world data so far. Methods: Leveraging data from the UK Biobank, encompassing 445,493 individuals aged 40-69, we examined associations of high 25-hydroxyvitamin (25[OH]D) levels >100 nmol/L and vitamin D supplementation with hypercalcemia (plasma calcium >2.6 mmol/L), kidney stones, and atherosclerosis assessments (pulse wave arterial stiffness index and carotid intima-medial thickness). Regression models were comprehensively adjusted for 49 covariates.
Results: Approximately 1.5% of the participants had high 25(OH)D levels, 4.3% regularly used vitamin D supplements, and 20.4% reported regular multivitamin use. At baseline, the hypercalcemia prevalence was 1.6%, and 1.1% were diagnosed with kidney stones during follow-up. High 25(OH)D levels were neither associated with calcium-related adverse events nor atherosclerosis assessments. Vitamin D and multivitamin supplementation were associated with an increased prevalence of hypercalcemia (odds ratios and 95% confidence intervals: 1.46[1.32-1.62] and 1.11[1.04-1.18], respectively) but were neither associated with atherosclerosis nor future kidney stones.
Conclusion: High 25(OH)D levels observable in routine care were not associated with any adverse outcome. Vitamin D users have a slightly higher prevalence of hypercalcemia, possibly due to cosupplementation with calcium, but without higher atherosclerosis prevalence or risk of kidney stones.
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VitaminDWiki - Overview Kidney Stones and vitamin D
VitaminDWiki - Many health problems need more than 40 ng of Vitamin D
| Vitamin D | Treats |
| 150 ng | Multiple Sclerosis * |
| 80 ng | Cluster Headache * Reduced office visits by 4X * |
| 70 ng | Sleep * |
| 60 ng | Breast Cancer death reduced 60% Preeclampsia RCT |
| 50 ng | COVID-19 Fertility Psoriasis Infections Review Infection after surgery |
| 40 ng | Breast Cancer 65% lower risk Depression ACL recovery Hypertension Asthma? |
| 30 ng | Rickets |
* Evolution of experiments with patients, often also need co-factors