178 items in Vitamin D Binding Protein category - Increased risk of health problems if poor VDBP
- VDBP is NOT directly detected by vitamin D blood tests
- MS and Vitamin D Binding Protein
7 studies - TB and Vitamin D Binding Protein -
4 studies - Breathing and Vitamin D Binding Protein -
7 studies - Infant-Child and Vitamin D Binding Protein -
8 studies - Pregnancy and Vitamin D Binding Protein -
10 studies - Vitamin D Binding Protein and Its Gene Polymorphisms —The Risk of Malignant Tumors and Other Diseases - Oct 2020
178 VDBP studies - Low response to Vitamin D can be improved in many ways
- See also web
- Vitamin D Binding Protein mutations are not noticed by the Vitamin D Test – March 2024
- Studies of VDBP and diseases: Pregnancy 10, Skin - Dark 8, Breathing 7, Infant-Child 7, Multiple Sclerosis 6, Virus 6, Cardiovascular 6, Diabetes 5, Autoimmune 4, Cancer - Other 4, Obesity 4, Tuberculosis 4 – Jan 2024
178 items in Vitamin D Binding Protein category See also Vitamin D Receptor Genetics CYP27B1
Did you know?
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Increased risk of health problems if poor VDBP
Increased
RiskHealth Problem 11 X Preeclampsia 6.5X T1D in SA Blacks 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2.8 X MS 2.5 X Severe Autism 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility VDBP is NOT directly detected by vitamin D blood tests
MS and Vitamin D Binding Protein
7 studies - Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D genes increase MS relapses in children by 2X – May 2019
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is associated with about 1.5 X more Vitamin D Binding Protein – Jan 2015
- Late-stage MS associated with protein in spinal cord which blocks vitamin D – Jan 2013
TB and Vitamin D Binding Protein -
4 studies - Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021
- Tuberculosis not treated by monthly 140,000 IU (Vitamin D binding protein problem) – RCT Sept 2017
- TB lowers vitamin D, then HIV lowers it even more - 2014
- Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014
Breathing and Vitamin D Binding Protein -
7 studies - Asthma more closely associated with poor VDBP gene than with poor Vitamin D level – June 2014
- COPD in Asians twice as likely if poor Vitamin D Binding Protein – meta-analysis May 2019
- COPD strongly associated with Vitamin D Binding Protein problems – meta-analysis Aug 2015
- Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
- Vitamin D Binding Protein, And Airflow In COPD - April 2012
- Genetic link found between vitamin D and COPD – June 2010
- How vitamin D helps the lung via vitamin D-binding protein - May 2010
Infant-Child and Vitamin D Binding Protein -
8 studies - Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018
- Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
Pregnancy and Vitamin D Binding Protein -
10 studies - Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preeclampsia 11X more likely if poor Vitamin D Binding Protein (South Africa) - Sept 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Fetal Growth poor if Vitamin D-Binding Protein gene poor – Feb 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Preeclampsia changes to Vitamin D Binding Protein reduces Vitamin D in placenta – Dec 2016
- Bio-available Vitamin D is reduced by half during pregnancy – Jan 2017
- Changes during pregnancy of vitamin D (decrease), DBP (2X) and albumin (0.8X) – Oct 2014
Vitamin D Binding Protein and Its Gene Polymorphisms —The Risk of Malignant Tumors and Other Diseases - Oct 2020
178 VDBP studies - wiki page:
- Autism has a 2.5 X higher risk of being severe if poor Vitamin D Binding gene – Nov 2024
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- The potential role of vitamin D binding protein in kidney disease: a comprehensive review – Jan 2024
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies
- Many genes can restrict Vitamin D from getting to the cells – Aug 2023
- Vitamin D and it’s related genes regulate the immune system – Aug 2023
- Melanoma death risk 0.63 X lower if poor Vitamin D Binding Gene – July 2023
- 12 Vitamin D genes (Most are not noticed by blood test) – Sept 2021
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Parkinson’s Disease, low vitamin D and Vit. D genetics – Jan 2023
- Response to Vitamin D - many studies
- Vitamin D genes may be more important than (25(OH)D) to orthopedics – Review Dec 2022
- Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022
- Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes) Sept 2022
- 10,000 years of gene changes: increasing many health problems, 2 Vitamin D changes, – Aug 2022
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Some COVID hospitalizations are due to poor Vitamin D genes (Binding Protein in this commentary) – June 2022
- Vitamin D genes – Review June 2022
- Vitamin D metabolism and genes as of Nov 2019
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Poor vision associated with poor Vitamin D or poor Vit. D genes – June 2022
- Multiple Sclerosis 2.8 X more likely if poor Vitamin D Binding Protein – May 2022
- Poor genes (DBP, CYP24A1, CYP2R, etc.) restrict Vitamin D to cells, increasing COVID hospitalization – May 2022
- Better handgrip strength if some good vitamin D genes (or if supplement) – April 2022
- Gene variants can reduce Vitamin D response by 1.7X (14,000 IU daily, Multiple Sclerosis) – Dec 2021
- Vitamin D Binding Protein may affect immune system dendritic cells – March 2022
- Poor Vitamin D Binding Protein Genes increase the risk of various diseases – Jan 2022
- Lower vitamin D associated with several new genes (Korea GWAS) – Dec 2021
- Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- Vitamin D levels in cells, not blood, is important (IVF follicular fluid in this case) – Aug 2021
- COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021
- Higher risk of pulmonary tuberculosis if any of 3 vitamin D genes are poor – April 2021
- Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Familial Mediterranean Fever is associated with poor Vitamin D Binding Protein – Nov 2020
- Vitamin D in the blood encounters many restrictions in getting to the cells – Sept 2020
- Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020
- During pregnancy less Vitamin D due to increased Vitamin D binding Protein – May 2020
- Colorectal Cancer death 2.1X more likely if poor Vitamin D plus poor Vitamin D Binding protein – May 2020
- Vitamin D genes vary with UVB in Europe, Africa, Asia – March 2020
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- 2 X better survival of digestive cancer if 2,000 IU of Vitamin D plus good VDBP gene – RCT Feb 2020
- Sweat types, folate, binding protein, lighter skin in females and Vitamin D – Jan 2020
- Vitamin D may be a magic bullet for the cells (not based on Vitamin D blood tests) – Jan 2020
- Does survival of the less fit mean less health (poor genes may be inherited)
- A poor Vitamin D Binding protein can confirm various clinical diagnoses - Dec 2019
- Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019
Low response to Vitamin D can be improved in many ways
- No response to Vitamin D was 11 X more likely to have if poor Binding gene – Sept 2022
- Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies
- Reasons for low response to vitamin D
See also web
- Meta-analysis of vitamin D-binding protein and cancer risk Sept 2015
- "Results: We found a borderline decrease in cancer risk for subjects with high compared to low levels of DBP"
- "We included 28 independent studies concerning: basal cell carcinoma, bladder, breast, colon-rectum, endometrium, liver, esophagus, stomach, melanoma, pancreas, prostate and kidney. "
Vitamin D Binding Protein mutations are not noticed by the Vitamin D Test – March 2024
Factors to take into account when interpreting 25-hydroxy-vitamin D serum levels
Acta Clin Belg. 2024 Mar 7:1-6. doi: 10.1080/17843286.2024.2327218 – PDF behind a $65 paywall
Joris R Delanghe 1, Marijn M Speeckaert 2 3, Thomas Maenhout 1Background: Assessing vitamin D status, typically evaluated using serum or plasma 25-hydroxy vitamin D [25(OH)D] concentration, is complex because of various influencing factors.
Methods: Seasonality significantly affects intra-individual variability in 25(OH)D levels. This variation can be addressed by employing cosinor functions that are tailored to the geographical location of the patient to correct for seasonal effects. In addition to seasonality, genetic factors, such as DBP polymorphism and body composition, particularly adiposity, play crucial roles. Dialysis patients with DBP 2-2 phenotype exhibit higher vitamin D requirements. Genotyping/phenotyping of DBP allows for better tailored vitamin D supplementation. The lipid-soluble nature of vitamin D also interacts with plasma components such as serum triglycerides, which can influence vitamin D measurements. Adiposity, which is negatively correlated with vitamin D concentration, necessitates body mass-based mathematical adjustments for accurate vitamin D assessment in subjects with extreme BMI values.
Conclusions: Accordingly, vitamin D replacement therapy must be personalized, taking into account factors such as body size and seasonal variations, to effectively reach the target serum 25(OH)D concentrations.
Introduction (from DeepDyve)
Owing to a markedly increased interest in the role of vitamin D in human health, the determination of 25- hydroxy vitamin D [25(OH)D] in serum or plasma has become a frequently requested laboratory test [1 ]. This rise in popularity can be attributed not only to the growing recognition of the wide-ranging health implications of vitamin D [2,3] but also to significant advancements in the effectiveness of vitamin D analysis techniques [3].The intraindividual biological variability (CVI) has been reported to be 4.7% for 25-hydroxy vitamin D. In contrast, interindividual variation (CVG), representing diverse homeostatic points among subjects within the same population, was significantly higher at 64.3% for 25(OH)D [4]. The calculated reference change value (RCV) for 25(OH)D was 18.0%. These data indicate that interindividual variation markedly surpasses intraindividual variation in 25(OH)D levels [4].
On top of the biological variation of 25(OH) vitamin D, in moderate and Arctic climates, vitamin D levels exhibit significant seasonal variability, primarily due to changes in sunlight exposure. This variability becomes more pronounced with increasing distance from the equator, with studies indicating a marked decrease in vitamin D synthesis in populations at higher latitudes. The biological mechanisms underlying this phenomenon, including the reduced capacity of the skin to synthesize vitamin D under lower UV conditions, warrant further discussion [5,6].
Vitamin D, a fat-soluble vitamin, relies on a specific transport protein, known as the vitamin D binding protein (DBP), for its circulation in the bloodstream. This binding protein plays a crucial role in the bioavail- abilitv and metabolic reoulation of vitamin D. nosino a complex challenge for interpreting the vitamin D status from serum or plasma 25(OH)D concentrations. The complexities of this relationship, particularly in different physiological and pathological states, emphasize the need for a more nuanced approach to vitamin D analysis [7].Most clinical laboratories tend to oversimplify the interpretation of vitamin D status by comparing test results with generic 'summer' and 'winter' reference values. These seasonal reference values, which are often inadequately defined, fail to offer a comprehensive correction for individual variability and geographical differences, leading to potential misinterpretations in vitamin D status assessment. The scientific basis for these reference values, as well as alternative methodologies that might provide more accurate assessments, are areas ripe for exploration [8-10].
Most clinical laboratories tend to oversimplify the interpretation of vitamin D status by comparing test....
Studies of VDBP and diseases: Pregnancy 10, Skin - Dark 8, Breathing 7, Infant-Child 7, Multiple Sclerosis 6, Virus 6, Cardiovascular 6, Diabetes 5, Autoimmune 4, Cancer - Other 4, Obesity 4, Tuberculosis 4 – Jan 2024
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8 pages in both categories: Vit D Binding Protein + Skin - Dark
59 pages in both categories: Vit D Binding Protein + Genetics
47 pages in both categories: Vit D Binding Protein + Vitamin D Receptor
22 pages in both categories: Vit D Binding Protein + CYP27B1
4 pages in both categories: Vit D Binding Protein + Cancer - Other
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6 pages in both categories: Vit D Binding Protein + Cardiovascular
10 pages in both categories: Vit D Binding Protein + Pregnancy
8 pages in both categories: Vit D Binding Protein + Infant-Child
6 pages in both categories: Vit D Binding Protein + Multiple Sclerosis
5 pages in both categories: Vit D Binding Protein + Diabetes
4 pages in both categories: Vit D Binding Protein + Tuberculosis
4 pages in both categories: Vit D Binding Protein + Kidney
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