Vitamin D Workshop presentations and posters - Sept 2022

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Presentations

• George Georgiou (UT-Austin) - Molecular level decomposition of the identity, dynamics and function of the constituent antibodies comprising the serum antibody repertoire in response to infection or vaccination.
• John White (McGill University) Recent updates on the role of vitamin D signaling in innate and adaptive immunity.
• Lori Plum (University of Wisconsin, Madison) Antibody production does not require vitamin D or its receptor.
• Juhi Arora (Pennsylvania State University) Vitamin D and the ability to produce 1,25(OH)2D are critical for protection from viral infection of the lungs.
• Isabelle Piec (University of East Anglia) Vitamin D status was associated with better immune response to SARS-COV-2 immunisation.
• Behdad Afzali (NIDDK) Regulation of T cells by complement activation of a vitamin D system.
• Nicole Froelich (Pennsylvania State University) Developmental control of the vitamin D receptor in T cells.
• Chin May Teoh (Texas State University) Methyl-donor nutrients supplemented to a high-fat diet during pregnancy and lactation alters colonic vitamin D signaling and inflammatory status among offspring rats.
• Vanessa McGaughey (University of Miami) Mechanisms of vitamin D-dependent presentation of tumortargeting neoantigens in osteosarcoma.
• Megan Rodgers (Medical University of South Carolina) Early vitamin D sufficiency is associated with long term neurodevelopmental improvements in 4-6 year old children.
• Yuko Nakamichi (Matsumoto Dental University) The vitamin D receptor in osteoblastic cells is crucial for the proresorptive activity, hypercalcemia, and soft tissue calcification induced by 1a,25(OH)2D3.
• Margherita Cantorna (Pennsylvania State University) The role of the VDR and the effect of vitamin D deficiency on the development of immune cells.
• Carol Wagner (Medical University of South Carolina) The effect of maternal vitamin D status during lactation on the human milk proteome.
• Sonya Ketchens (Medical University of South Carolina) Supplementation of vitamin D in black American pregnant to decrease adverse pregnancy outcomes.
• Jane K. Cleal (University of South Hampton) Placental uptake and metabolism of 25(OH)vitamin D determines its activity within the fetoplacental unit.
• Philip Atherton (University of Nottingham) The vitamin D receptor and skeletal muscle proteostasis.
• Megan Knuth (University of North Carolina Chapel Hill) Developmental vitamin D deficiency alters adult liver energy metabolism pathways.
• Jeffrey Roizen (Children's Hospital of Philadelphia) High dose dietary vitamin D enhances energy sensing and allocates surplus calories to build muscle and increase linear growth by decreasing myostatin and enhancing leptin signaling.
• Shelby Bollen (University of Nottingham) Vitamin D receptor and vitamin D binding protein polymorphisms are associated with skeletal muscle function and physiology in elite master athletes.
• Luke Peppone (University of Rochester Medical Center) High-dose vitamin D supplementation in patients with breast and prostate cancer to prevent cancer-treatment-induced bone loss.
• Sakoto Kise (Toyama Prefectural University) Functional analysis of vitamin D receptor (VDR) using adenovirus vector and its application to gene therapy for VDR KO rats.
• Dan Bikle (UCSF/VA Medical Center) Vitamin D receptor controls injury induced epidermal regeneration through cross-talk with P53/63 signaling.
• Ayse Kilic (Brigham and Women's Hospital, Harvard) Vitamin D mitigates allergic airway inflammation by modulating the expression of key genes on CHR17Q12-21.1.
• Morgan Ritter (North Carolina State University) Early disruption of vitamin D receptor signaling induces developmental behavior deficits in zebrafish.
• Nicole Ball (University of East Anglia) 3'UTR structural elements are associated with CYP24A1-mediated abnormal calcium handling.
• Jim Fleet (University of Texas Austin) Integrating genomic and physiologic data to understand how vitamin D signaling regulates intestinal biology.
• Natalie Watkins (University of Texas Austin) Intestinal epithelial cell-deletion of CYP24A1 reduces renal CYP27B1 mRNA and enhances TRPV6 mRNA induction by low dietary calcium.
• Snehal Chaudhari (Harvard / UW-Madison) The role of vitamin D receptor in remodeling the gut-liver axis following bariatric surgery.
• Thomas Lisse (University of Miami) Vitamin D inhibits the epithelial-mesenchymal transition (EMT) and migration of osteosarcoma cells via differential regulation of EMT and antioxidative genes and chromatin states.
• Ganmaa Davaasambuu (Harvard School of Public Health) Maternal vitamin D intakes during pregnancy and child health outcomes.
• Martyna Stachowicz-Suhs (Hirszfeld Institute) Crosstalk between macrophages and murine 4T1 breast cancer cells in the context of the vitamin D-induced metastasis: COX-2/ PGE-2/ IL-6 as the main factors driving this process.
• Kirstin Krieger (University of Illinois Chicago) Vitamin D sufficiency enhances epithelial differentiation of mouse prostate organoids and cancer cell lines.
• Steven Strugnell (OPKO Health) Extended-release calcifediol may accelerate resolution of respiratory symptoms and mitigate pneumonia risk in patients with mild-moderate COVID-19.
• Mark B. Meyer (University of Wisconsin, Madison) The rapid genomic mechanisms controlling renal vitamin D metabolism.
• Glenville Jones (Queen's University) R396W mutation of CYP24A1: a humanizedpreclinical model of infantile hypercalcemia Type I.
• Etienne Sochett (Hospital for Sick Children, Toronto) Rifampin use in children with idiopathic infantile hypercalcemia.
• Martin Kaufmann (Queen's University) Clinical Utility of measuring the serum vitamin D metabolome including 24,25(OH)2D3 by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Eva Liu (Brigham and Women's Hospital/Harvard) Role of 1,25 dihydroxyvitamin D in regulating enthesopathy development in the HYP mouse model of XLH.
• Stefanie Doms (KU Leuven) The vitamin D3 analog, WY1048, affects cortical bone directly through VDR induced signaling in osteoblast precursors.
• Seong Min Lee (University of Wisconsin, Madison) A complex genomic mechanism governs the regulation of fibroblast growth factor 23 expression in response to 1,25-dihydroxyvitamin D3, phosphate and inflammation.
• Serra Ucer Ozgurel (University of Texas Austin) Male LRP5 A214V mutant mice with genetically programmed high bone mass have disruption of the vitamin D endocrine system.
• Lieve Verlinden (KU Leuven) Osteoblast-specific deletion of neuropilin 2 results in trabecular and cortical bone loss in male mice.
• Sudhaker Rao (Henry Ford Health) Effect of vitamin D metabolites on bone histomorphometry in health black and white women: an attempt to unravel the so-called Vitamin D Paradox in blacks.
• Clayton Yates (Tuskegee University) Prostate cancer and vitamin D - GWAS, skin color and health disparities
• Madhu Biyani (Kanazawa University) A novel DNA aptamer for CYP24 inhibition exerts a therapeutic effect by enhancing anti-proliferative function of vitamin D in lung cancer cells.
• Cydney Dennis (Virginia Commonwealth University) 24R,25(OH)2D3 induces its anti-apoptotic effect in laryngeal cancer cells through a PLD mediated mechanism.
• Rocio Garcia-Becerra (Universidad Nacional Autonoma de Mexico) Re-establishment of the antitumoral effects of antiestrogens by calcitriol in triple-negative breast cancer models.
• Susan A. Lanham-new (University of Surrey, UK) Differential effects of vitamin D2 and vitamin D3 on vitamin D metabolism in health and disease.
• Tom Thacher (Mayo Clinic) Serum 1,25-dihydroxyvitamin D and the pathogenesis of vitamin D/calcium deficiency rickets - a multivariable re-analysis.
• Sue Shapses (Rutgers University) Vitamin D deficiency in older mice causes excess weight gain and compromises the biomechanical strength of bone without a decrease in BMD.
• Sophie Davies (University of Bath) 25(OH)D3 expenditure does not differ meaningfully between active, lean and sedentary overweight adults.
• Roger Bouillon (Leuven, Belgium) Calcifediol as a treatment option for hypovitamin D.

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Plenary Posters

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