Changes in Parameters of Bone Metabolism in Postmenopausal Women Following a 12-Month Intervention Period Using Dairy Products Enriched with Calcium, Vitamin D, and Phylloquinone (Vitamin K1) or Menaquinone-7 (Vitamin K2): The Postmenopausal Health Study II
CALCIFIED TISSUE INTERNATIONAL
Volume 90, Number 4 (2012), 251-262, DOI: 10.1007/s00223-012-9571-z
International Osteoporosis Foundation
Spyridon Kanellakis, George Moschonis, Roxane Tenta, Anne Schaafsma, Ellen G. H. M. van den Heuvel, Nikolaos Papaioannou, George Lyritis and Yannis Manios
Comment on the web
After a year of supplementation, subjects in the K1 and K2 groups showed significantly lower ratios of undercarboxylated (inactivated) osteocalcin to carboxylated osteocalcin than subjects in the other groups, suggesting better bone utilization of available calcium.
Deoxypyridinoline, a common marker of bone breakdown, was significantly lower in the vitamin K groups compared to the placebo group and the calcium and vitamin D group.
Total-body bone mineral density was improved in all test groups compared to placebo, but lumbar spine bone mineral density improved only in the vitamin K groups.
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Wish it said if there was any difference between K1 and K2