- Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial
- See also Google Scholar
- See also VitaminDWiki
-
26 Items in both categories Cardiovascular and Vitamin K 29 Items in both categories Bones and Vitamin K - See also Life Extension Magazine Nov 2017
- See also web
- There have been
15085 visits to this page
Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial
Thrombosis and Haemostasis, DOI: http://dx.doi.org/10.1160/TH14-08-0675
M. H. J. Knapen (1), L. A. J. L. M. Braam (1), N. E. Drummen (1), O. Bekers (2), A. P. G. Hoeks (3), C. Vermeer (1)
(1) VitaK & Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands; (2) Central Diagnostic Laboratory, University Hospital Maastricht, The Netherlands; (3) Biomedical Engineering, Maastricht University, The NetherlandsObservational data suggest a link between menaquinone (MK, vitamin K2) intake and cardiovascular (CV) health. However, MK intervention trials with vascular endpoints are lacking. We investigated long-term effects of MK-7 (180 µg MenaQ7/day) supplementation on arterial stiffness in a double-blind, placebo-controlled trial. Healthy postmenopausal women (n=244) received either placebo (n=124) or MK-7 (n=120) for three years. Indices of local carotid stiffness (intima-media thickness IMT, Diameter end-diastole and Distension) were measured by echotracking. Regional aortic stiffness (carotid-femoral and carotid-radial Pulse Wave Velocity, cfPWV and crPWV, respectively) was measured using mechanotransducers. Circulating desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP) as well as acute phase markers Interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), tumour necrosis factor-α (TNF-α) and markers for endothelial dysfunction Vascular Cell Adhesion Molecule (VCAM), E-selectin, and Advanced Glycation Endproducts (AGEs) were measured. At baseline dp-ucMGP was associated with IMT, Diameter, cfPWV and with the mean z-scores of acute phase markers (APMscore) and of markers for endothelial dysfunction (EDFscore).
After three year MK-7 supplementation- cfPWV and the Stiffness Index β significantly decreased in the total group, whereas
- distension,
- compliance,
- distensibility,
- Young’s Modulus, and the
- local carotid PWV (cPWV)
improved in women having a baseline Stiffness Index β above the median of 10.8.
MK-7 decreased dp-ucMGP by 50 % compared to placebo, but did not influence the markers for acute phase and endothelial dysfunction.
In conclusion, long-term use of MK-7 supplements improves arterial stiffness in healthy postmenopausal women, especially in women having a high arterial stiffness.Download the PDF from VitaminDWiki
See also Google Scholar
Google Scholar has links to 234 papers citing this study as of July 2023
- Vitamin K2—a neglected player in cardiovascular health: a narrative review - Nov 2021 FREE PDF
- Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial - April 2022 10.1161/CIRCULATIONAHA.121.053708 FREE PDF
- 720 µg MK-7 plus 25 µg vitamin D for 24 months did not help those with severe plaque
- Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial) 2015, full text online, no publication of that trial as of Aug 2017
- Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness 2017, full text online
See also VitaminDWiki
- Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015
- Interview of Vitamin K2 and Calcium Paradox author by Dr. Mercola – Dec 2012
- Overview Vitamin K and Vitamin D many items by Vermeer, who co-authored this paper
- Arterial stiffness reduced by vitamin D
- Hypothesis – Vascular calcification is associated with both too much and too little vitamin D - May 2018\
26 Items in both categories Cardiovascular and Vitamin K - Vitamin K, cardiovascular health, and stroke - many studies
- Bone loss results in blood vessel plaque if low Vitamin K2, less bone loss if high K2– April 2021
- Cardiovascular Disease prevented by Vitamin K2-4 when enough is used – RCT review Sept 2020
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Vitamin K reduces calcification (reported yet again) – Feb 2019
- Vitamin K (across all dose sizes and types) decrease Vascular Stiffness – meta-analysis - Dec 2018
- Vitamin D and Vitamin K together fight CVD Part 1- Pizzorno
- Vitamin K, Cardiovascular and interactions with Vitamin D and Vitamin A – Pizzorno July 2018
- Mortality associated with Vitamin K insufficiency (PREVEND Study) – Nov 2017
- Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017
- Decalcify Aortic Valve – 3 year trial with 1 mg of Vitamin K and 5,000 IU of Vitamin D – 2021
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Athletes maximal cardiac output increased 12 percent with Vitamin K2 – RCT July 2017
- Fast blood flow 6.8 X more likely if high vitamin D AND high vitamin K – Aug 2017
- Low Vitamin K2 is as risky as smoking for heart disease - Oct 2016
- Cardiovascular death: 9 percent due to hypertension or air pollution, 7 percent: low Vitamin K2 or smoking – Oct 2016
- Decreased need for warfarin after Vitamin D levels optimized – RCT May 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- The health benefits of vitamin K – Oct 2015
- If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015
- Vitamin K2-7 decreases arterial stiffness (cleans arteries) – RCT Feb 2015
- Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Cholesterol, Vitamins D3 and K2, heart disease, sulfates, LDL, – Masterjohn Interview Jan 2013
- Soft Bones, Hard Arteries, Vitamin D, Vitamin K2 and antibiotics – Sept 2012
- Low Vitamin D and Vitamin K: brittle bones and hardened arteries – LEF Sept 2010
29 Items in both categories Bones and Vitamin K - Which supplements are often taken for healing hairline bone fractures
- Vitamin K2-7 helps bone, blood vessels, cancer, diabetes, etc. – June 2022
- Role of Vitamin K in Bones and Muscles - Feb 2022
- Bone loss results in blood vessel plaque if low Vitamin K2, less bone loss if high K2– April 2021
- Bone increased : Stiffness (Vitamin D), Flexibility (Vitamin K2) – Sept 2020
- Bone quality improved 2X by Vitamin D plus Vitamin K2 (trend) – meta-analysis March 2020
- Vitamin D and Calcium do not increase bone density (also need exercise, Mg, K2, protein etc.) – RCT Aug 2019
- Vitamin K (any amount and any kind) reduced bone fractures by 24 percent – meta-analysis – May 2019
- Calcium Supplementation is OK provided you also take Vitamin K – Feb 2019
- Hard bones, soft arteries, rather than vice versa (Vitamin D and Vitamin K) – March 2016
- Many seniors do not get enough protein, Vitamin D, Mg, etc. needed for bones – Feb 2019
- Adding just vitamin D again failed to add bone density (also need Magnesium, Vitamin K, etc) – RCT Aug 2018
- Osteocalcin – overview of the hormone needed to build bones, etc. Jan 2018
- Vitamin K and bone – review Oct 2017
- Bone formation in the lab is aided by Vitamin D, Vitamin K1, and Vitamin K2 – meta-analysis Nov 2017
- Better bones again associated with higher vitamin K intake – Nov 2015
- Vitamin K-2 – bone biomarkers indicate at least 600 ug of MK-4 are needed daily – Sept 2014
- Vitamin K2 (as MK-7) is needed for bone quality – Review Feb 2013
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
- Vitamin K and bone health – need more research Oct 2013
- Vitamin K-2 (180 ug MK-7) helped both bone density and strength – RCT March 2013
- Healthy bones need Ca, Silicon, Vitamins B, C, D, and K – Dec 2012
- Increasing bone mineral density increases breast cancer by at least 2X – Aug 2012
- Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Vitamin D, K2, Magnesium, etc increase bone density when taking together– Jan 2012
- BONE SPURS not produced if have enough Vitamin D3, Vitamin K2, etc. – Nov 2011
- Vitamin K1 reduced hip fracture but Vitamin K2 did not – Aug 2011
- Women with hip fractures very low on vitamins D3 and K – Mar 2011
- Vitamin K2 from natto improved bone mineral density – March 2011
See also Life Extension Magazine Nov 2017
Download "Vitamin K Reverses Arterial Stiffness" from VitaminDWiki
has 62 references
See also web
- Arterial Stiffness Index and Coronary Artery Plaques in Patients with Subclinical Coronary Atherosclerosis - Jan 2015 - doi: 10.6515/ACS20140630B FREE PDF
- Carotid artery plaque and arterial stiffness = about conflicts between ultrasound and tonometry and between local and global Aug 2017
- Chronic plaque psoriasis is associated with increased arterial stiffness - 2009
short url = is.gd/K2CalciumRCT
There have been
15085 visits to this page Vitamin K2-7 decreases arterial stiffness (cleans arteries) – RCT Feb 2015Printer Friendly Follow this page for updates2733 visitors, last modified 22 Jul, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 15345 Psorasis vs PWV.jpg admin 30 Mar, 2021 22.30 Kb 716 15344 Chronic Plaque Psoriasis 2009 sci-hub.pdf admin 30 Mar, 2021 118.45 Kb 309 8578 LEF Vit K Nov 2017.pdf admin 22 Oct, 2017 908.28 Kb 2260 8315 Arterial stiffness 2015.jpg admin 19 Aug, 2017 53.77 Kb 2734 8314 arterial stiffness.pdf admin 19 Aug, 2017 247.41 Kb 1084