Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 Supplementation on Recovery of Symptoms in Patients with Mild to Moderate Covid-19: A Randomized Clinical Trial
Nutrients 2021, 13(7), 2170; https://doi.org/10.3390/nu13072170
by Shaun Sabico 1OrcID,Mushira A. Enani 2,Eman Sheshah 3,Naji J. Aljohani 1,4,Dara A. Aldisi 5,Naif H. Alotaibi 6,Naemah Alshingetti 7,Suliman Y. Alomar 8OrcID,Abdullah M. Alnaami 1,Osama E. Amer 1OrcID,Syed D. Hussain 1 and Nasser M. Al-Daghri 1,*OrcID
5,000 IU statistically reduced only 2 of 11 mild symptoms
Note: Ageusia is associated with loss of taste
Vitamin D 21 ng ==> 25 ng
COVID-19 treated by Vitamin D - studies, reports, videos
- As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries
Note: >70% of the RCT using Vitamin D to fight COVID-19 were using at least 100,000 IU during the first week
The founder of VitaminDWiki had predicted very little success in RCTs using less
Note: Clincal trials in hospitals using much higher doses of Vitamin D have found far better results
Also: Those people who had been taking a good amount of vitamin D before COVID were
1) Less likely to get infected
2) Less likely to need to go to hospital
3) Less likely to have severe COVID-19
4) Less likely to die of COVID-19
Items in both categories Virus and Intervention:
- Over 48 Virus studies have RCT in the title
- Viral infections reduced 40% by monthly 100,000 IU Vitamin D – RCT review Aug 2024
- Long-COVID fatigue, anxiety, and cognition treated by 60,000 IU of vitamin D weekly – RCT July 2024
- 15.3 X fewer COVID deaths in those getting Vitamin D injections in ICU – RCT July 2024
- After COVID infection, Vitamin D helps - many studies
- Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024
- COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis May 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis March 2024
- 5 X less COVID infection of health care workers who took lots of vitamin D – meta-analysis Feb 2024
- COVID deaths cut in half by a single dose of 600,000 IU of Vitamin D - RCT Jan 2024
- COVID in hospital stopped by Vitamin D Receptor activators (curcumin, quercetin) – RCT June 2023
- Vitamin D Supplements Don’t Reduce COVID-19 Risk (used only 3,200 IU daily) - Oct 2022
- High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ – Oct 2022
- COVID in hospital fought by Vitamin D (25,000 IU daily for 4 days, then 25K weekly) - RCT – July 2022
- Small Vitamin D doses for a short time never help (not improve vaccination in this case) – RCT Sept 2022
- The challenges of a Vitamin D RCT – too many already taking it, etc. – Martineau Sept 2022
- Early COVID treatments rarely work 7 days after symptoms, this trial gave Vitamin D on 7th day – RCT May 2022
- COVID children helped by Vitamin D, trial terminated: unethical to not give Vitamin D to all: – RCT July 2022
- COVID hospital deaths reduced 2X by 8 days of UVB – pilot RCT May 2022
- 21 fewer days in hospital with ARDS (COVID) if 10,000 IU of Vitamin D daily after enter hospital – RCT April, 2022
- 4X less likely to get COVID following 4,000 IU daily for a month – RCT April 2022
- Risk of COVID not reduced by 3,200 IU of vitamin D during 6 months (no surprise) – RCT March 2022
- Group achieving 30 ng (vs 26 ng) were 2X less likely to get COVID symptoms - RCT Jan 2022
- Tested positive for COVID, taking probiotics stopped symptoms 5 days sooner - RCT Jan 2022
- Vitamin D given slowly in hospital did not fight COVID-19 much - Nov 2021
- Nursing home vaccinated against Influenza, 800 IU of vitamin D daily cut infection rate in half – small RCT Oct 2021
- COVID-19 appears reduced by Resveratrol plus 100K IU of vitamin D – Small RCT Sept 2021
- Vitamin D trial for COVID-19 – using their patented slow-release form – Aug 2021
- COVID-19 mortality reduced 4X (chart looks like 2X) by large, infrequent doses of Vitamin D in France – July 2021
- COVID-19 outpatients getting Quercetin nanoemulsion had excellent outcomes (Q increased Vitamin D in cells) – RCT – June 2021
- 5,000 U daily raised Vitamin D a bit and helped COVID-19 a bit – RCT June 2021
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Better response to shingles virus after 6,400 IU Vitamin D raised above 40 ng – Jan 2021
- COVID-19 ICU survival rate increased 7X by daily Omega-3 – RCT March 2021
- Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021
- Vitamin D not help 10 days after COVID-19 symptoms - RCT March 2021
- 5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021
- calcifediol rct
- COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020
- COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020
- Swine flu not prevented by 2,000 IU of vitamin D daily (the upper limit at the time) – RCT 2014
- Influenza vaccine antibodies not change with Vitamin D – 21 ng or 44 ng – RCT Feb 2019
- Dengue virus prevented by a small amount of Vitamin D – RCT Nov 2019
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Chikungunya virus arthritis pain reduced by weekly 60,000 IU vitamin D – Sept 2016
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015
- Infection fighting ability increased with 5,000 IU Vitamin D daily – April 2015
- Vitamin D prevents Hepatitis-C and helps treat it (many studies)
Download the PDF from VitaminDWiki
Objective: Vitamin D deficiency has been associated with an increased risk of COVID-19 severity. This multi-center randomized clinical trial aims to determine the effects of 5000 IU versus 1000 IU daily oral vitamin D3 supplementation in the recovery of symptoms and other clinical parameters among mild to moderate COVID-19 patients with sub-optimal vitamin D status. Study
Design and Setting: A total of 69 reverse transcriptase polymerase chain reaction (RT-PCR) SARS-CoV-2 positive adults who were hospitalized for mild to moderate COVID-19 disease were allocated to receive once daily for 2 weeks either 5000 IU oral vitamin D3 (n = 36, 21 males; 15 females) or 1000 IU oral vitamin D3 (standard control) (n = 33, 13 males; 20 females). Anthropometrics were measured and blood samples were taken pre- and post-supplementation. Fasting blood glucose, lipids, serum 25(OH)D, and inflammatory markers were measured. COVID-19 symptoms were noted on admission and monitored until full recovery.
Results: Vitamin D supplementation for 2 weeks caused a significant increase in serum 25(OH)D levels in the 5000 IU group only (adjusted p = 0.003). Within-group comparisons also showed a significant decrease in BMI and IL-6 levels overtime in both groups (p-values < 0.05) but was not clinically significant in between-group comparisons. Kaplan–Meier survival analysis revealed that the 5000 IU group had a significantly shorter time to recovery (days) than the 1000 IU group in resolving cough, even after adjusting for age, sex, baseline BMI, and D-dimer (6.2 ± 0.8 versus 9.1 ± 0.8; p = 0.039), and ageusia (loss of taste) (11.4 ± 1.0 versus 16.9 ± 1.7; p = 0.035).
Conclusion: A 5000 IU daily oral vitamin D3 supplementation for 2 weeks reduces the time to recovery for cough and gustatory sensory loss among patients with sub-optimal vitamin D status and mild to moderate COVID-19 symptoms. The use of 5000 IU vitamin D3 as an adjuvant therapy for COVID-19 patients with suboptimal vitamin D status, even for a short duration, is recommended.