Annual Ambient UVB at Wavelengths that Induce Vitamin D Synthesis is Associated with Reduced Esophageal and Gastric Cancer Risk: A Nested Case-Control Study
February 2018 Photochemistry and Photobiology 94(5), DOI: 10.1111/php.12915
Fiona O'SullivanJos van GeffenJos van GeffenM. van WeeleM. van WeeleLina ZgagaLina Zgaga
- Getting little UV is associated with 15 types of Cancer – Jan 2012
- Vitamin D needed for 12 ng in winter in Finland – Whites 320 IU, Blacks 720 IU – July 2018
- Multiple Sclerosis rates are highest in Canada (far from equator) – May 2018
- Brain cancer in 175 countries related to low UVB and low vitamin D – Oct 2010
- MS onset 2 years earlier in northern latitudes – June 2010
- Breast Cancer vs latitude
- Solar UVB reduces Cancer Risk – Grant, Jan 2013
- US Cities with least amount of sunshine - top 15 all in Washington
- Founder of VitaminDWiki lives near Seattle
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Vitamin D has been shown to be beneficial at reducing the risk of cancer, however studies examining oesophageal and gastric cancer have been scarce and findings inconsistent. The UK Biobank cohort was used for this nested case‐control study (N=3,732). Primary, incident oesophageal and gastric cancer cases diagnosed after recruitment were identified via linkage to National Cancer Registries. Tropospheric emissions monitoring internet service database was used to calculate ambient annual UVB dose (D‐UVB). Conditional logistic regression was used to investigate the relationship between annual ambient D‐UVB and risk of oesophageal and gastric cancer and odds ratios (OR) are reported. In total, 373 oesophageal and 249 gastric cancer cases and 3,110 age‐ and gender‐matched controls were included in the study.
We found a strong inverse association between annual ambient UVB and odds of developing oesophageal or gastric cancer: compared to the lowest tertile, OR for the highest tertile was 0.64 (95%CI:0.51‐0.79) in adjusted analysis. The association was strengthened when restricted to oesophageal cancer (OR=0.60;95%CI:0.45‐0.80), and oesophageal adenocarcinoma cases (OR=0.48;95%CI:0.34‐0.68). Similar results were found in unadjusted and stratified analysis. In conclusion, ambient UVB radiation is inversely associated with the development of oesophageal and gastric cancer, even in a high latitude country.