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Gut problems associated with low vitamin D (dogs in this case) – Sept 2024


Dysregulated serum concentrations of fat-soluble vitamins in dogs with chronic enteropathy
J Vet Intern Med. 2024 Sep-Oct;38(5):2612-2619. doi: 10.1111/jvim.17107
Federica Serafini 1, Kristen M Maxwell 2, Xiaojuan Zhu 3, Elizabeth M Lennon 1

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Background: In inflammatory bowel disease (IBD) of humans, nutrient malabsorption can result in fat-soluble vitamin deficiency, especially of vitamin D. In veterinary species, decreased concentrations of vitamin D are relatively common in dogs with chronic enteropathy (CE), but data on the status of other fat-soluble vitamins (FSVs) is lacking.

Objectives: Determine the serum concentrations of retinol, vitamin D, and α-tocopherol in dogs with CE compared with healthy dogs and compare clinical, clinicopathologic variables between CE and healthy dogs to detect associations with decreased FSVs concentrations.

Animals: Eighteen client-owned dogs with CE and 33 healthy dogs.

Methods: Serum 25-hydroxyvitamin D (25[OH]D), serum retinol and α-tocopherol concentrations were compared between groups. Correlations and multiple regression modeling were used to examine the relationship between serum 25(OH)D, retinol, and α-tocopherol concentrations and clinical and clinicopathological variables.

Results: Dogs with low serum albumin concentrations were more likely to have lower 25(OH)D concentrations than dogs with normal serum albumin concentration. Dogs with CE had higher serum concentrations of retinol, and variable α-tocopherol concentrations. The cause of these dysregulated vitamin concentrations is unclear and requires further study.

Conclusion and clinical importance: Dogs with severe forms of CE should be monitored for decreased concentrations of 25(OH)D. Additional studies are needed to evaluate the clinical relevance and the possible benefit of vitamin D supplementation in these patients.
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Gut problems are treated with Gut-Friendly Vitamn D (not regular)

VitaminDWiki – Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
   you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be usefulit is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


VitaminDWiki - Overview Veterinary and vitamin D contains:

Veterinary category has 151 items

Animals need Vitamin D too

Pets as well

Farm Vets are paid when their "patients" are healthy,
   vs doctors who are paid only when "patients" become sick

Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)
Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')
Virtually all US farmers who raise livestock use feed that is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight


26+ VitaminDWiki Veterinary pages have DOG or CAT in the title

The list is automatically updated

Items found: 25
Title Modified
Gut problems associated with low vitamin D (dogs in this case) – Sept 2024 26 Sep, 2024
Cats 8.2X more likely to die in 30 days if low vitamin D when enter hospital – May 2015 25 Sep, 2024
Vitamin D is great for dogs and cats too 24 May, 2024
Cats often have similar range of Vitamin D as humans - 10 to 30 ng - Jan 2024 26 Jan, 2024
450,000 IU of Vitamin D daily too much for a cat - Aug 2021 18 Aug, 2021
Calcidiol increased blood levels of Vitamin D in one month (dogs) – Feb 2021 10 Jun, 2021
Poor immune system associated with low Vitamin D (dogs in this case) – June 2020 05 Aug, 2020
Many non-bone diseases associated with low Vitamin D (dog and cats in this study) – Dec 2019 06 Dec, 2019
Some Dog food had excess vitamin D, first dry food, then canned – Speculation Feb 2019 03 Feb, 2019
Acute pancreatitis in dogs is associated with low vitamin D (lowest D equals death) – Aug 2017 18 Sep, 2018
Half of dogs now get cancer, it used to be just 1 percent (probably low Vitamin D) 08 May, 2018
Critically ill dogs with good levels of vitamin D have much better outcomes (humans too) – March 2018 29 Mar, 2018
Companion animals (dog, cats) need vitamin D too – March 2016 19 Mar, 2018
Dogs, cats, rabbits, guinea pigs, pet birds, etc need Vitamin D 18 Feb, 2018
Atopic dermatitis treated by Vitamin D (in dogs too) - RCT Feb 2018 04 Feb, 2018
Dogs, like humans, need vitamin D for many reasons – Jan 2018 23 Jan, 2018
Dogs with Cancer have low vitamin D, same as humans – Sept 2017 24 Sep, 2017
Cats with feline HIV and hospitalized cats have low levels of vitamin D – Nov 2015 28 Nov, 2015
Dog Cancer 4X more likely if low Vitamin D – Nov 2015 22 Nov, 2015
Dog Cancer (hemangiosarcoma) is rare if more than 100 ng of vitamin D – July 2014 22 Nov, 2015
Rickets increasing in dogs 17 Oct, 2015
Hospitalized cats 8X more likely to die if low vitamin D (Vit. D helps humans too) – May 2015 11 Sep, 2015
Controversy cats and vitamin D 19 Jan, 2014
Inflammatory Bowel Disease and Lymphoma – associated with low vitamin D in cats too – Jan 2014 19 Jan, 2014
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012

Note: First category in VitaminDWiki was Veterinary - they were far ahead of human doctors in understanding the imporance of Vitamin D

Attached files

ID Name Comment Uploaded Size Downloads
21805 CE vit D dogs.webp admin 26 Sep, 2024 9.01 Kb 41
21804 chronic enteropathy in dogs_CompressPdf.pdf admin 26 Sep, 2024 227.71 Kb 7