Hodgkin’s lymphoma and Vitamin D Receptor - June 2012

Vitamin D3 receptor is highly expressed in Hodgkin’s lymphoma.

Christoph Renne, Alexander Benz and Martin L Hansmann
BMC Cancer 2012, 12:215 doi:10.1186/1471-2407-12-215; Published: 6 June 2012

Background
Hodkin’s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as potential therapeutic target structure in Hodgkin’s lymphoma as well as in non Hodgkin’s lymphoma.

Methods
We used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of Hodgkin s lymphoma and 138 cases on several non Hodgkin’s lymphoma entities.

Results
Vitamin D receptor is strongly expressed in Hodgkin s lymphoma, regardless of the subentity with an overall positivity of 80% of all Hodgkin lymphoma cases.
In contrast, only about 17% of the analyzed non Hodgkin’s lymphoma of B-cell origin showed positivity for vitamin D receptor.
Predominant nuclear localization of vitamin D receptor in Hodgkin’s lymphoma suggests activated status of the vitamin D receptor.

Conclusions
From this study, we conclude that vitamin D receptor plays a potentially important role in pathogenesis of Hodgkin’s lymphoma but not in non Hodgkin’s lymphoma. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in Hodgkin’s lymphoma.

Provisional PDF is attached at the bottom of this page

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See also VitaminDWiki

• All items in category Lymphoma and vitamin D 26 items
• Hypothesis: Blacks get more cancer than whites due to lower levels of vitamin D – June 2012 includes Hodgkin's lymphoma

Vitamin D Receptor and Cancers

89+ Vitamin D Receptor pages with CANCER in the title
This list is automatically updated

The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019

Vitamin D Receptor table shows what compensates for low VDR activation
Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Vitamin D Receptor category has the following

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

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Increased risk of diseases if poor VDR

Increased risk associated with a poor Vitamin D Receptor
   Note: Some diseases reduce VDR activation
those with a * are known to decrease activation

Risk increase	Health Problem
50	Lyme Disease *
28	Leprosy - another says 3X
15	Chronic Heart Failure
15	Temporary hair loss
14.7	Childhood solid cancers
14	Hand, Foot, and Mouth disease
13	Sepsis
12	COVID Death
11	Metabolic Syndrome
9.6	Chronic Periodontitis    and smoke
8	Juvenile Rheumatoid Arthritis
8.0	Preterm birth
7.6	Crohn's disease
7.5	Respiratory Tract Infections
7.0	Lung Cancer
5.8	Low back pain in athletes
5	Respiratory Distress in preemies
5	Ulcerative Colitis
5	Coronary Artery Disease
5	Asthma Child see also 1.3, 2.0 and 3.7
4.6	Breast Cancer * 16.9 X another study
4.3	Severe COVID in kids
4.1	Vitiligo
4	Liver Cirhosis
4	Polycystic ovary syndrome
3.8	Lupus
3.6	Pneumonia - children
3.3	Pre-term birth
3.1	Colon Cancer survival
3	Multiple Sclerosis
3	Dengue
3	Waist size
3	Ischemic Stroke
3	Alzheimer’s 9X in women
3	Parkinson’s
3	Gestational Diabetes
2.9	Hand, Foot, Mouth Disease
2.8	Osteoporosis & COPD
2.7	Gastric Cancer
2.6	Lupus in children
2.5	Lumbar Disc Degeneration
2.4	Lung Cancer
2.3	Cardio
2.3	Autism
2.2	Juvenile idiopathic arthritis
2.1	Adolescent idiopathic scoliosis in Asians
2	Obesity
2	Diabetic Retinopathy
2	Parkinson's
2	Wheezing/Asthma see also 5X
2	Melanoma   Non-melanoma Skin Cancers
2	Myopia
2	Preeclampsia
1.9	Uterine Fibroids
1.9	Early tooth decay
1.8	Diabetic nephropathy
1.8	Sleep Apnea
1.6	Diabetes - Type I
1.6	Prostate Cancer while black
1.5	Diabetes -Type II
1.5	Gout
1.5	Pertussis
1.5	Obesity
1.4	Graves Disease
1.4	Rheumatoid arthritis
1.3	Hypertension
1.3	Childhood asthma see also 5X
1.3	Psoriasis in Caucasians
1.3	Tuberculosis