Table of contents
- Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial
- VitaminDWiki -
28 studies in both categories Omega-3 and Depression - VitaminDWiki -
14 studies in both categories Omega-3 and Obesity - Obese tend to consume more Omega-6, so need more Omega-3
Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial
J Clin Psychiatry. 2022 Aug 22;83(5):21m14074. doi: 10.4088/JCP.21m14074. PDF is behind a $40 paywall
David Mischoulon 1 2 3 , Boadie W Dunlop 4 2 , Becky Kinkead 4 , Pamela J Schettler 4 , Stefania Lamon-Fava 5 , Jeffrey J Rakofsky 4 , Andrew A Nierenberg 1 , Alisabet J Clain 1 , Tanja Mletzko Crowe 4 , Andrea Wong 4 , Jennifer C Felger 4 , Lisa Sangermano 1 , Thomas R Ziegler 6 , Cristina Cusin 1 , Lauren B Fisher 1 , Maurizio Fava 1 7 , Mark Hyman Rapaport 4 8 7Objective: This study compared the impact of 3 eicosapentaenoic acid (EPA) doses versus placebo on inflammatory biomarkers and depressive symptoms.
Methods: Sixty-one unmedicated adults (75% female; 45.5 ± 13.8 years) with DSM-5 major depressive disorder (MDD), body mass index > 25 kg/m2, and plasma high-sensitivity C-reactive protein (hs-CRP) ≥ 3.0 mg/L were randomly assigned to receive EPA 1 g/d, 2 g/d, or 4 g/d or placebo for 12 weeks. Prespecified endpoints were a ≥ 0.40 effect size decrease in plasma interleukin (IL)-6, peripheral blood mononuclear cell (PBMC) cytokines, and lipopolysaccharide-stimulated tumor necrosis factor (TNF) production. Response was defined as a ≥ 50% decrease of Inventory of Depressive Symptomatology, Clinician-Rated version (IDS-C30) scores. We compared outcomes for the 3 EPA doses versus placebo.
Results: In 45 completers, only median PBMC TNF decreased at 2 g/d EPA. No EPA dose produced a ≥ 0.35 effect size reduction in plasma IL-6 or mitogen-stimulated TNF. Response rates for EPA 4 g/d were 64%, versus 40% for placebo (odds ratio OR = 2.63; Cohen d = 0.53), 38% for EPA 1 g/d, and 36% for EPA 2 g/d (all P > .05). EPA 4 g/d showed a significant correlation between percent decrease in plasma hs-CRP and IDS-C30 symptom reduction at 12 weeks (Spearman ρ = 0.691, P = .019).
Conclusions: EPA 4 g/d demonstrated a medium effect size for response rates versus placebo. This dose may alleviate MDD in overweight individuals with elevated inflammatory markers, and change in hs-CRP may be correlated with clinical response.
VitaminDWiki -
28 studies in both categories Omega-3 and Depression This list is automatically updated
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022
- Omega-3 did not prevent depression (they failed to reduce Omega-6, which blocks Omega-3) – RCT Dec 2021
- Mental health not helped by vitamin D monotherapy (adding Omega-3 and Magnesium help) – review Nov 2021
- Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021
- Depression treatments: diet, exercise, bright light, Vitamin D, B12, Omega-3, Zinc, Music, etc. – May 2019
- Omega-3 helps treat Major Depression – International Consensus Sept 2019
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018
- Depression treated by Omega-3 (again) – meta-analysis Aug 2019
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Occupational burnout reduced after 8 weeks of Omega-3 – RCT July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Psychotic disorders not treated by Omega-3 when patents take anti-depressants and get therapy – June 2018
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Depression – is it reduced by Vitamin D and or Omega-3 – RCT 2019
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Omega-3 improves gut bacteria, reduces inflammation and depression – Dec 2017
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- Omega-3 does not consistently treat depression if use small amounts for short time period – review Oct 2016
- How Omega-3 Fights Depression – LEF July 2016
- Depression due to inflammation reduced by Omega-3 (children and pregnant) – Nov 2015
- Depression treated somewhat by Omega-3 (St. John's Wort better) – RAND org reviews 2015
- Depression substantially decreased with Omega-3 – Sept 2015
- Omega-3 for just 3 months greatly reduced psychosis for 80 months – RCT Aug 2015
- Omega-3 prevents PTSD and some mood disorders - Aug 2015
- Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015
VitaminDWiki -
14 studies in both categories Omega-3 and Obesity This list is automatically updated
- Omega-3 added to father’s diet reduced offspring’s obesity (mice) – June 2024
- Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022
- 4 weeks of Omega-3 better than 2 week 800 calorie diet before Bariatric Surgery – RCT March 2019
- Omega-3 may reduce weight gain and maintain weight loss – Aug 2018
- Severe Non-Alcoholic fatty liver disease treated by Omega-3 – RCT April 2018
- How Omega-3 fights metabolic syndrome and weight – Feb 2018
- NAFLD in children nicely treated by combination of Vitamin D and Omega-3 – RCT Dec 2016
- Obese youths 2X less likely to develop Metabolic Syndrome if take Omega-3 – RCT April 2016
- Omega-3 in infancy reduces Obesity following antibiotic (confirmed in rats, suspected in humans) – Feb 2016
- Huge increases in Omega-6 to Omega-3 ratio increase risk of obesity, etc. – March 2016
- Overweight women on caloric restriction diet got 3X benefits from 8 weeks of Omega-3 – RCT Dec 2015
- Hypothesis – Omega-6 to Omega-3 ratio increases obesity – Nov 2015
- Omega-3 reduced vitamin D3 inflammation for obese – RCT Jan 2013
- Reasons for low response to vitamin D
Obese tend to consume more Omega-6, so need more Omega-3
Omega-3 index is the important measure ignored by this paper.
VitaminDWiki pages with OMEGA-3 INDEX in title
This list is automatically updatedItems found: 21Overweight needed more EPA (4 grams) to fight depression – RCT Aug 2022Printer Friendly Follow this page for updates748 visitors, last modified 30 Aug, 2022, This page is in the following categories (# of items in each category) - VitaminDWiki -