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Antibiotic, Antimicrobial Resistance, and Vitamin D - many studies

Does Vitamin D play a significant role in antimicrobial defense? - asked Perplexity AI Dec 2024

Vitamin D plays a crucial role in antimicrobial defense through multiple mechanisms, particularly by enhancing both innate and adaptive immune responses.
Antimicrobial Mechanisms
Direct Antimicrobial Effects
Vitamin D demonstrates antimicrobial properties against both Gram-positive and Gram-negative bacteria, as well as fungi and viruses  1  4
 It exerts direct bactericidal activity against various pathogens, including Helicobacter pylori, Streptococcus mutans, and Mycobacterium tuberculosis  4
Antimicrobial Peptide Production
The vitamin D-cathelicidin axis is a key component of antimicrobial defense. Vitamin D stimulates the expression of potent antimicrobial peptides, particularly:

  • Cathelicidin (LL-37)
  • β-defensin 2  1

These peptides are present in various immune cells, including neutrophils, monocytes, natural killer cells, and respiratory tract epithelial cells  1
Immune System Enhancement
Innate Immunity
Vitamin D strengthens innate immunity by:

  • Increasing macrophage oxidative burst potential
  • Facilitating neutrophil motility and phagocytic function
  • Enhancing monocyte and macrophage activity  1

Adaptive Immunity
Vitamin D modulates T-cell responses by:

  • Suppressing inflammatory T helper (Th1) and Th17 cells
  • Inducing immunotolerogenic T regulatory responses  9

Clinical Significance
Research has demonstrated that vitamin D supplementation can reduce the risk of respiratory tract infections by up to 70% in vitamin D-deficient individuals  3
 This protective effect is particularly notable when using daily doses rather than large bolus doses  8
Therapeutic Potential
Vitamin D represents a promising and cost-effective option for:

  • Preventing infections
  • Serving as an adjunct to traditional antimicrobial treatments
  • Potentially reducing antibiotic resistance by decreasing inappropriate antibiotic prescriptions  1

Antimicrobial Resistance deaths may exceed Cancer deaths by 2050

MDEdge Dec 2024
AMR is responsible for 1.27 million global deaths annually.

  • "“If this trend continues, it is entirely reasonable to predict that in 25 years, some antibiotics will become useless, certain bacterial infections will be much harder to treat, and deaths will outnumber those caused by cancer."

45+ VitaminDWiki pages have ANTIBIOTIC or ANTIMICROBIAL in the title

The list is automatically updated

Items found: 45
Title Modified
Antibiotic, Antimicrobial Resistance, and Vitamin D - many studies 27 Dec, 2024
Fathers taking antibiotics at time of conception had 3X higher infant deaths (mice – so far) – May 2024 04 May, 2024
10,000,000 deaths annually in 2050 due to antibiotics no longer working (vitamin D can help) 28 Jun, 2021
Bacterial infections reduced by Vitamin D without antibiotics – Oct 2019 24 Jun, 2021
Antibiotic resistance interactions – Oct 2015 24 Jun, 2021
Antibiotic resistance charts by Information Is Beautiful - 2014 24 Jun, 2021
Vitamin D may reduce Respiratory Tract Infections and the use of antibiotics – March 2021 24 Jun, 2021
Antibiotic use decreased after supplementing with 1500 IU of Vitamin D – Sept 2016 23 Jun, 2021
Vitamin D reduces Respiratory Tract Infections and reduces use of antibiotics – March 2021 15 Apr, 2021
Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019 31 Dec, 2019
Antibiotics in children associated with low Vitamin D and short height (Ethiopia) – March 2019 29 Jul, 2019
Antibiotics found in many rivers – June 2019 11 Jun, 2019
Antibiotics during pregnancy may cause childhood health problems – Feb 2019 13 Feb, 2019
Antibiotics and Vitamin D are associated with many of the same diseases 23 Nov, 2018
Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018 02 Jun, 2018
Kidney Stones risk increased 1.3 X to 2 X by antibiotics, especially children – May 2018 11 May, 2018
Child Asthma increased 2.1 X by antibiotics, Child milk allergy increased 4.4 X by PPI – April 2018 02 Apr, 2018
Antibiotic usage US map is very similar to obesity US map - June 2015 06 Mar, 2018
5 Antibiotic courses raised risk of diabetes by 37 percent (200,000 diabetics, more than 1 year after antibiotic) - 2015, 2016 24 Jan, 2018
RSV (bronchitis and viral pneumonia) in infants associated with low vitamin D and antibiotics – Aug 2015 10 Jan, 2018
Exposing some blood to Ultraviolet light has treated various health problems, then antibiotics came along – April 2016 11 Nov, 2017
Huge increases in health problems – risk factors include Vitamin D, Antibiotics, and Roundup 07 Aug, 2017
Antibiotics, probiotics 22 Nov, 2016
Antimicrobial implications of vitamin D – Oct 2011 17 Nov, 2016
Antibiotic use cut in half by elderly (over 70) after monthly 60,000 IU of vitamin D – RCT Dec 2013 06 Oct, 2016
Off topic: Ecoli adapts to 1000 times toxic dose of antibiotics in just 11 days – Sept 2016 20 Sep, 2016
Antimicrobial peptides (which attack pathogens) are increased by Vitamin D, etc. – May 2014 01 Sep, 2016
Antimicrobial peptides (which attack pathogens) are increased by Vitamin D 01 Sep, 2016
Hypothesis – Multiple Sclerosis risk increases with low UV, viral infections, and antibiotics in childhood – March 2015 31 Aug, 2016
2000 IU vitamin D during pregnancy and 800 IU to infant resulted in less use of antibiotics – RCT April 2014 17 Apr, 2016
Omega-3 in infancy reduces Obesity following antibiotic (confirmed in rats, suspected in humans) – Feb 2016 14 Apr, 2016
Autism associated with low gut flora (due to antibiotics) – Mercola Oct 2014 01 Dec, 2015
Diabetes risk increased by 50 percent if had 5 courses of antibiotics – Aug 2015 09 Sep, 2015
Antibiotics, even short-term, cause long-term microbiome and metabolic changes in mice – June 2015 13 Jul, 2015
Antibiotic resistance will kill 300 million in 35 years, FDA doing nothing, UK considering wrong things – Feb 2015 18 Feb, 2015
Medical use of antibiotics increased 36 percent globally in a decade – Aug 2014 16 Jan, 2015
Hypothesis: antibiotic resistant bacteria can be controlled with vitamin D 11 Jan, 2015
1.8X increased risk of Obesity if antibiotics were used during pregnancy – Nov 2014 29 Dec, 2014
Do antibiotics given to speedup weight gain in farm animals result in decreased vitamin D for humans 06 Dec, 2014
The Antibiotic Effects of Vitamin D – 2014 24 Nov, 2014
Low-level antibiotics causes weight gain in mice (and most mammals) – Aug 2014 09 Nov, 2014
Antimicrobial peptides and proteins can be boosted by vitamin D, etc. – May 2014 14 Oct, 2014
Soft Bones, Hard Arteries, Vitamin D, Vitamin K2 and antibiotics – Sept 2012 20 Jul, 2014
antibiotics and vitamin D 20 Jul, 2014
Antibiotics for Q-Fever result in photosensitivity and huge drop in vitamin D levels – Dec 2013 20 Jun, 2014

42+ VitaminDWiki pages have SEPSIS (an example AMR) in the title

The list is automatically updated

Items found: 42
Title Modified
Kidney disease with sepsis: mortality reduced 40% by Vitamin D (dose not specified) - Dec 2024 17 Dec, 2024
People with Sepsis and Kidney injury and who got vitamin D were much more likely to survive – Dec 2024 02 Dec, 2024
Sepsis (with mechanical ventilation) treated by 5days of 50,000 IU of Vitamin D – RCT May 2024 06 May, 2024
Sepsis mortality greater in Black than White children (low vitamin D) - Dec 2023 03 Dec, 2023
Sepsis 2X-3X more likely if poor Vitamin D Receptor – meta-analysis Sept 2023 27 Sep, 2023
Sepsis is both prevented and treated by Vitamin D - many studies 25 Sep, 2023
Sepsis is fought by Vitamin D in 9 ways – Feb 2023 13 Feb, 2023
Doctors Still Struggle to Diagnose a Condition That Kills More Than Stroke (Sepsis, Vitamin D helps) Oct 2022 16 Oct, 2022
Sepsis patients 2.7 X more likely to die if low Vitamin D – Aug 2022 11 Aug, 2022
Vitamin D and infectious diseases like RTI, TB and Sepsis – Nov 2014 16 Jan, 2022
Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells) – Aug 2021 16 Aug, 2021
Vitamin C IV, which treats Sepsis, also treats COVID-19 - May 2020 01 Aug, 2020
3X less Septic Shock in children with sepsis getting 150,000 IU of Vitamin D - RCT June 2020 03 Jun, 2020
Role and Mechanism of Vitamin D in Sepsis (Chinese) – Feb 2020 27 Feb, 2020
Omega-3 reduced pancreas transplant failure by 3X and sepsis by 2X – review Dec 2019 18 Dec, 2019
Fewer Burn problems if adequate Vitamin D – Less ICU, Hospital, Sepsis (10X) – Dec 2019 17 Dec, 2019
Treatment of neonate sepsis greatly aided by Vitamin D – RCT June 2019 27 Jun, 2019
Sepsis mortality cut in half with Omega-3 – RCT Sept 2017 14 Apr, 2019
Sepsis reduced the Omega-3 response and half life – April 2019 14 Apr, 2019
Vitamin D for Sepsis prevention – June 2018 24 Jul, 2018
Omega-3 reduced cost of Sepsis by 2900 dollars per patient (12 RCT) – April 2018 24 Apr, 2018
Neonatal Sepsis 4.8 X more likely if poor Vitamin D receptor – June 2018 22 Apr, 2018
Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018 06 Apr, 2018
Sepsis in infants 4.8 X more likely if poor vitamin D receptor – March 2018 14 Mar, 2018
Vitamin D deficiency with severe sepsis increased risk of dying by 7.7 X – Nov 2017 20 Nov, 2017
Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023 23 Oct, 2017
Sepsis was present in 6 percent of US adult hospitalizations – JAMA Oct 2017 04 Oct, 2017
Infant sepsis strongly associated with low vitamin D – Aug 2014 16 Aug, 2017
Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017 24 Jul, 2017
Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017 13 Jun, 2017
Severe Sepsis associated with very low vitamin D – Sept 2016 26 May, 2017
Increased Hospital, Sepsis deaths if low vitamin D – March 2014 21 May, 2017
Sepsis in first year of life is much more likely if preterm (low Vitamin D) – May 2017 10 May, 2017
Vitamin D might reduce sepsis 04 May, 2017
More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013 21 Sep, 2016
Neonates with sepsis had half the levels of vitamin D - 2015 30 Aug, 2016
Newborns with sepsis – 9 ng of vitamin D, without sepsis 19 ng – Aug 2015 30 Aug, 2016
Sepsis associated with low vitamin D - April 2012 22 Mar, 2016
1.5X increased infection, sepsis, and death if in ICU with low vitamin D - Meta-analysis Dec 2014 20 Oct, 2015
More sepsis deaths in those entering hospital with low vitamin D – Jan 2014 07 Jun, 2014
ICU surgical patients with low vitamin D stayed longer and had more sepsis – Dec 2011 22 Jul, 2013
Sepsis bacteria can be killed by blue as well as UV light – Jan 2013 29 Jan, 2013

6+ VitaminDWiki pages have HOSPITAL and ACQUIRED in the title

The list is automatically updated

Items found: 6

VitaminDWiki – Immunity category contains

275 items in Immunity category

    see also

Virus category listing has 1401 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection
Image

52 studies are in both Immunity and Virus categories
Antibiotic, Antimicrobial Resistance, and Vitamin D - many studies        
56 visitors, last modified 27 Dec, 2024,
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Immunity 251 Antibiotics, probiotics 92 Microbiome 40 AI 115
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