See also "Autism, Vitamin D and Early Brain Development" 2016
Download the attached PDF from VitaminDWiki
Gestational vitamin D deficiency and autism-related traits:
the Generation R Study
Molecular Psychiatry advance online publication 29 November 2016; doi: 10.1038/mp.2016.213
A A E Vinkhuyzen1, D W Eyles1,2, T H J Burne1,2, L M E Blanken3,4, C J Kruithof3,5, F Verhulst4, V W Jaddoe3,5,6, H Tiemeier4,5 and J J McGrath1,2,7
- Overview Autism and vitamin D
- Autism 4 times more likely if low vitamin D during first trimester – Oct 2016
The TOP articles in Autism and Vitamin D are listed here:
- High-Dose Vitamin D Therapy – book July 2018
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- Autism associated with low vitamin D during pregnancy – Nov 2016
- Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- Autism is associated with low vitamin D – meta-analysis Oct 2015
- Most Autism Risk factors are associated with low vitamin D - March 2014
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Dr. Cannell on Autism – Spring 2013
- Autistic measure 5X more likely if low vitamin D in second trimester – Oct 2012
Items in both categories Autism and Pregnancy are listed here:
- 24% lower risk of Autism for every 4 ng higher level of vitamin D during pregnancy – Feb 2024
- Autism risk if toxins, heavy metals, microplastics, etc during pregnancy (unless add Vitamin D) – Feb 2024
- Autism reduced 24% for each 4 ng more Vitamin D while pregnant ( ADHD 12%) – Feb 2024
- Low maternal Vitamin D results in larger portion of brain associated with autism – Jan 2020
- Autism risk increased 30 percent by Cesareans (both low vitamin D) – meta-analysis Sept 2019
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Conception in winter increases rate of Autism, learning disabilities, dyslexia – Oct 2016
- Autism associated with low Zinc during pregnancy (Zinc is needed by Vitamin D Receptor) – July 2018
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Hypothesis: male autism risk increased if placental virus and low vitamin D – Feb 2018
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Autism rate cut in half when multivitamins (including vitamin D) used during pregnancy – Oct 2017
- ADHD 2 X more likely if Tylenol used a lot during pregnancy (Autism increased too) – Dec 2016
- Autistic child 2.4 X more likely if less than 10 ng of vitamin D during 2nd trimester – April 2017
- Autism risk increased by 44% if there were pregnancy and labor complications (probably low vitamin D) – Kaiser Jan 2017
- Herpes virus infection while pregnant increases Autism risk by 2 X (Vitamin D not mentioned) – Feb 2017
- Autism associated with low vitamin D during pregnancy – Nov 2016
- Autism 2.1 times more likely if obese and PCOS (relationships to vitamin D not mentioned) Oct 2016
- Autism 17 times more likely with excessive Folic Acid and B-12 (now added to bread) – May 2016
- Autism with intellectual disability 2.5 times more likely if low vitamin D during pregnancy – April 2016
- Autism risk increased if short time between pregnancies (no surprise) – April 2016
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
- All pregnant women (in UK) should have free vitamin D – Gillie Aug 2015
- Autistic measure 5X more likely if low vitamin D in second trimester – Oct 2012
- Low vitamin D in pregnancy and 2X worse language skills later – Feb 2012
- Autism has different causes but same inflammation in brain in half of autistics – May 2011
- Hypothesis being tested: 5000 IU prevent second autistic child - May 2010
- Vitamin D Newsletter May 2010
- Autism and Vitamin D - Newsletter April 2010
Autism treated by Vitamin D: Dr. Cannell - video June 2013
includes many reasons why he believes Autism is related to Vitamin D
- Both have strong inheritance features – Vitamin D about 60%
- Both have gotten substantially worse in last 30 years
- Vitamin D is known to be involved in brain development
- All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
- When giving vitamin D to cure children of rickets “mental dullness” decreases as well
- Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
- Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
- Both associated with weak bones
- Both worse around the age of weaning
- Autism is more common in rich families – more likely to apply sun screen and stay indoors
- Autism increases with drugs which lower levels of vitamin D
- Seizures are common with Autism - Vitamin D has been shown to reduce seizures
- Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
- Both worse with latitude
- Both vary with Ultraviolet light
- Both vary with time of year (more birth of autistics in March in Northern hemisphere)
- 2X more urban autism – less UVB in urban environments
- Both worse with pollution
- Both worse with increased clouds and rain
- Both worse with closely spaced pregnancies
- Autistics have abnormal immune response – similar to that of vitamin D deficiency
- Low levels of vitamin D in mother animals reduces brain function in offspring
- Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
- Autistic children get less vitamin D in their blood for the same amount of sun exposure
- The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
- Both worse in African Americans (A-A 2-3 increased autism rate)
- Both worse in Dark-skinned immigrants in Europe
- Note: All articles in Autism category
163 items Social Responsiveness (SRS) of 22,000 Japanese school children - lower score is better
Download the PDF from VitaminDWiki1Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia
2Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia
3The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
4Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
5Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
6Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
7National Centre for Register-Based Research, Aarhus University, Aarhus C, Denmark
Correspondence: Professor JJ McGrath, Queensland Brain Institute, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. E-mail: j.mcgrath at uq.edu.auThere is intense interest in identifying modifiable risk factors associated with autism-spectrum disorders (ASD). Autism-related traits, which can be assessed in a continuous fashion, share risk factors with ASD, and thus can serve as informative phenotypes in population-based cohort studies. Based on the growing body of research linking gestational vitamin D deficiency with altered brain development, this common exposure is a candidate modifiable risk factor for ASD and autism-related traits. The association between gestational vitamin D deficiency and a continuous measure of autism-related traits at ~6 years (Social Responsiveness Scale; SRS) was determined in a large population-based cohort of mothers and their children (n=4229). 25-hydroxyvitamin D (25OHD) was assessed from maternal mid-gestation sera and from neonatal sera (collected from cord blood). Vitamin D deficiency was defined as 25OHD concentrations less than 25 nmol l 1. Compared with the 25OHD sufficient group (25OHD>50 nmol l 1), those who were 25OHD deficient had significantly higher (more abnormal) SRS scores (mid-gestation n=2866, β=0.06, P<0.001; cord blood n=1712, β=0.03, P=0.01).
The findings persisted- (a) when we restricted the models to offspring with European ancestry,
- (b) when we adjusted for sample structure using genetic data,
- (c) when 25OHD was entered as a continuous measure in the models and
- (d) when we corrected for the effect of season of blood sampling.
Gestational vitamin D deficiency was associated with autism-related traits in a large population-based sample. Because gestational vitamin D deficiency is readily preventable with safe, cheap and accessible supplements, this candidate risk factor warrants closer scrutiny.
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