Clin Nutr. 2023 May 17;S0261-5614(23)00151-6. doi: 10.1016/j.clnu.2023.05.009
Tafirenyika Gwenzi 1, Anna Zhu 2, Petra Schrotz-King 3, Ben Schöttker 4, Michael Hoffmeister 5, Hermann Brenner 6
Background & aims: Inflammation plays a key role in tumor development and progression. Vitamin D has potential tumor suppressing effects through modulation of inflammatory processes. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to summarize and evaluate the effects of vitamin D3 supplementation (VID3S) on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions.
Methods: We searched PubMed, Web of Science and Cochrane databases until November 2022. The effects of VID3S were estimated from pooled standardized mean differences (SMDs) with their 95% confidence intervals (CIs) for inflammatory biomarker follow-up levels between intervention and control groups.
Results: Meta-analysis of eight RCTs (total of 592 patients with cancer or pre-cancerous conditions) showed that VID3S significantly lowered levels of serum tumor necrosis factor (TNF)-α (SMD [95%CI]: -1.65 [-3.07; -0.24]). VID3S also resulted in statistically non-significantly lower serum levels of interleukin (IL)-6 (SMD [95%CI]: -0.83, [-1.78; 0.13]) and C-reactive protein (CRP) (SMD [95%CI]: -0.09, [-0.35; 0.16]), whereas IL-10 levels were unaltered (SMD [95%CI]: -0.00, [-0.50; 0.49]).
Conclusion: Our study shows evidence of a significant reduction of TNF-α levels by VID3S for patients with cancer or precancerous lesions. Patients with cancer or precancerous lesions may benefit from personalized VID3S in suppressing tumour-promoting inflammatory response.
Prospero registration number: CRD42022295694.
No such attachment on this page
Note: Many of the trials used too little vitamin D to be of any possible benefit
4+ VitaminDWiki Inflammation pages with CANCER in the title
This list is automatically updated
Items found: 4
VitaminDWiki – Cancer category contains
- Cancer
| 298 |
items Overview Cancer and vitamin D
- Cancer and Vitamin D - many studies
- After Cancer Diagnosis
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items
- Bladder Cancer
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items
- Breast Cancer
| 260 |
items Overview Breast Cancer and Vitamin D
- Colon Cancer
| 146 |
items Overview Cancer-Colon and vitamin D
- Leukemia
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items
- Liver Cancer
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items
- Lung Cancer
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items Overview Lung cancer and vitamin D
- Lymphoma Cancer
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items
- Other Cancer
| 66 |
items
- Ovarian Cancer
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items
- Pancreatic Cancer
| 58 |
items
- Prostate Cancer
| 105 |
items Overview Prostate Cancer and Vitamin D
- Skin Cancer
| 121 |
items Overview Suntan, melanoma and vitamin D
- Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
VitaminDWiki – Cancer increases if poor Vitamin D Receptor (not mentioned in study on this page)
Cancers get less Vitamin D when there is a poor Vitamin D Receptor
- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
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articles
- Breast Cancer and VDR
| 24 |
articles
- Colon Cancer and VDR
| 14 |
articles
- Prostate Cancer and VDR
| 7 |
articles
- Skin Cancer and VDR
| 10 |
articles
- Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
39+ VitaminDWiki Mortality pages have CANCER in the title
This list is automatically updated
Items found: 40
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US Cancer statistics - Jan 2025 |
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19 Feb, 2025 |
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Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 |
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28 Nov, 2024 |
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3 Cancers have higher mortality if high PTH (which can be lowered by Vitamin D) - Aug 2024 |
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15 Aug, 2024 |
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Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024 |
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01 May, 2024 |
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People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023 |
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23 Nov, 2023 |
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Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
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31 Jul, 2023 |
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Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023 |
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01 May, 2023 |
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Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
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30 Apr, 2023 |
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Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022 |
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03 Jul, 2022 |
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Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021 |
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15 Oct, 2021 |
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Cancer mortality not reduced by small vitamin D doses - Sept 2021 |
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21 Sep, 2021 |
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Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021 |
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17 Aug, 2021 |
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Deaths after Cancer Surgery higher in blacks (probably low vitamin D) – Dec 2020 |
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10 Jan, 2021 |
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Cancer patients in ICU with low vitamin D were 3.4 X more likely to die within a year – Dec 2020 |
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31 Dec, 2020 |
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Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
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09 Nov, 2020 |
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Cancer is leading cause of death - Vitamin D and Receptor activators help |
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09 Nov, 2019 |
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Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014 |
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08 Nov, 2019 |
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Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019 |
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10 Sep, 2019 |
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Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
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05 Jul, 2019 |
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People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
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05 Jul, 2019 |
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Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019 |
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07 May, 2019 |
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Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019 |
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13 Apr, 2019 |
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Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 |
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26 Nov, 2018 |
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Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival |
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10 Sep, 2018 |
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The “Deadly Breast Cancer Gene” Is A Myth, Lancet Study Confirms – Jan 2018 |
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13 Jan, 2018 |
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Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
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29 Dec, 2017 |
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Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
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13 Jun, 2017 |
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Death after Breast Cancer 2 times less likely if take lots of Magnesium – Dec 2015 |
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15 Jun, 2016 |
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Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 |
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09 Nov, 2014 |
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Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
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30 Sep, 2014 |
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Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014 |
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17 Jun, 2014 |
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Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
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More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
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Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
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08 Apr, 2014 |
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Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
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Vitamin D and Cancer Mortality – review Jan 2013 |
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17 Sep, 2013 |
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Mortality and Cancer varies with latitude in France too – 2010 |
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26 Oct, 2012 |
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More US deaths due to cancer than heart if dark skinned – Sept 2012 |
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18 Sep, 2012 |
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Lack of solar UVB in US is associated with some Cancers - 2006 |
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28 Dec, 2011 |
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Solar radiation, vitamin D and cancer incidence and mortality in Norway |
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13 Apr, 2010 |
20 Most-visited pages in Cancer (general) category
This list is automatically updated
Items found: 89
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Non-cancer colon growths 7 % less likely per 10 ng increase in Vitamin D – Oct 2011 |
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08 Dec, 2024 |
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Graphs of Vitamin D and Cancer – meta-analysis Dec 2011 |
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08 Dec, 2024 |
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Pancreatic cancer mortality 28% more likely if low vitamin D – meta-analysis Jan 2024 |
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28 Nov, 2024 |
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Analysis of 280 Breast Cancer meta-analyses: having low vitamin D was highly suggestive – umbrella July 2024 |
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28 Jul, 2024 |
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Bladder cancer in muscles 2.7 times more-likely if vitamin D less than 20 ng -meta-analysis May 2024 |
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23 May, 2024 |
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1.5X more likely to die of Prostate Cancer if low vitamin D when initially diagnosed – meta-analysis March 2024 |
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13 Mar, 2024 |
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Pancreatic Cancer survival 2.3 X more likely if good level of Vitamin D – meta-analysis Sept 2023 |
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15 Sep, 2023 |
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Thyroid Cancer 1.4 X higher risk if low vitamin D– meta-analysis Feb 2018 |
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29 Aug, 2023 |
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Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013 |
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31 Jul, 2023 |
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16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023 |
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22 May, 2023 |
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Melanoma is 1.4X more-likely if low Vitamin D – meta-analysis May 2023 |
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18 May, 2023 |
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Breast Cancer not prevented by vitamin D when use small doses or for just a short time – Meta-analysis April 2023 |
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11 May, 2023 |
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Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018 |
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30 Apr, 2023 |
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Breast Cancer risk - meta-analysis of 50 studies - Dec 2019 |
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25 Mar, 2023 |
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Ovarian Cancer 37 percent less likely if high vitamin D – meta-analysis March 2023 |
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20 Mar, 2023 |
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Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis Jan 2023 |
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08 Jan, 2023 |
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Melanoma might be suppressed by Vitamin D - many studies |
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25 Nov, 2022 |
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Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022 |
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13 Sep, 2022 |
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USPSTF says no evidence that Vitamins prevent CVD or Cancer (data disagrees) Aug 2022 |
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05 Sep, 2022 |
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Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022 |
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19 Aug, 2022 |
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Colorectal cancer 40 percent less likely if 1000 IU more Vitamin D – 21st meta-analysis – Oct 2021 |
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29 Oct, 2021 |
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Colorectal cancer 25 percent less likely if good level of Vitamin D – 20th meta-analysis – June 2021 |
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02 Jul, 2021 |
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Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020 |
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24 Nov, 2020 |
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Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020 |
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09 Nov, 2020 |
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Vitamin D fights 13 cancers – review of 35 meta-analyses – Oct 2020 |
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06 Oct, 2020 |
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Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020 |
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02 Oct, 2020 |
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Colorectal cancer treated by Vitamin D – 19th meta-analysis – Sept 2020 |
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17 Sep, 2020 |
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3X less risk of Liver cancer if more than 30 ng of vitamin D – meta-analysis July 2020 |
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28 Jul, 2020 |
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Liver Cancer 8 percent less likely for every 4 ng higher level of vitamin D – Meta-analysis April 2020 |
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02 Apr, 2020 |
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Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 |
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11 Jan, 2020 |
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Breast Cancer risk reduced 17 percent by 1 hour of daily summer sun – meta-analysis Jan 2020 |
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07 Jan, 2020 |
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Liver Cancer – higher risk if poor genes (Vitamin D receptor etc) – meta-analysis Dec 2019 |
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14 Dec, 2019 |
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Colon cancer both prevented and treated by Vitamin D – meta-analysis Dec 2019 |
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04 Dec, 2019 |
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Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 |
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09 Nov, 2019 |
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Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019 |
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05 Jul, 2019 |
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People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019 |
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05 Jul, 2019 |
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Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013 |
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16 Jun, 2019 |
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Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019 |
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13 Jun, 2019 |
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Variety of Vitamin D forms treat Prostate Cancer – RCT Review April 2019 |
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01 May, 2019 |
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Pancreatic cancer risk of death reduced 19 percent by Vitamin D – meta-analysis June 2017 |
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20 Mar, 2019 |
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Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019 |
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05 Mar, 2019 |
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16 percent less Prostate Cancer sometimes for each 10 ng vitamin D increase - meta-analysis Jan 2011 |
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13 Oct, 2018 |
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Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018 |
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15 Sep, 2018 |
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Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 |
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18 Jul, 2018 |
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Thyroid Cancer 1.3X higher risk if low vitamin D (yet again) – meta-analysis June 2018 |
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02 Jun, 2018 |
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Cancer not treated by Vitamin D when ignore dose size, type, and length of trial – meta-analysis April 2018 |
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09 Apr, 2018 |
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Pancreatic cancer risk reduced 25 percent by just 10 micrograms of Vitamin D or Vitamin B12 – meta-analysis March 2018 |
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30 Mar, 2018 |
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Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 |
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11 Jan, 2018 |
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Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017 |
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29 Dec, 2017 |
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Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017 |
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14 Dec, 2017 |
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Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017 |
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27 Jul, 2017 |
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Lymphoma, leukemia etc, survival poor if low vitamin D – meta-analysis March 2015 |
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06 Jul, 2017 |
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Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis May 2015 |
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06 Jul, 2017 |
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Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017 |
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13 Jun, 2017 |
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Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015 |
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22 Feb, 2017 |
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Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016 |
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22 Dec, 2016 |
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Colorectal Cancer recurrence not prevented by 1,000 IU of vitamin D – meta-analysis Dec 2016 |
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09 Dec, 2016 |
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Bladder cancer modifiable risk factors include low vitamin D – meta-analysis March 2016 |
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08 Dec, 2016 |
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Bladder cancer 60 percent less likely if have high vitamin D – meta-analysis Dec 2015 |
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08 Dec, 2016 |
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Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014 |
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12 Nov, 2016 |
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10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 |
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23 Sep, 2016 |
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Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015 |
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30 Mar, 2016 |
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Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis April 2015 |
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24 Dec, 2015 |
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Bladder cancer 25 percent less likely if have high vitamin D – meta-analysis Oct 2014 |
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24 Dec, 2015 |
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Cancer risk weakly associated with vitamin D-binding protein – meta-analysis Sept 2015 |
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15 Oct, 2015 |
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Colon cancer 30 percent more likely if low vitamin D – 12th meta-analysis Aug 2015 |
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14 Aug, 2015 |
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Obesity causes 20 percent of all cancer, low vitamin D may be the connection – meta-analysis - Sept 2014 |
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31 May, 2015 |
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Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015 |
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03 May, 2015 |
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Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015 |
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11 Dec, 2014 |
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Breast Cancer – review of 2 RCT did not find association with 1000 IU of Vitamin D – July 2013 |
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16 Nov, 2014 |
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Cancer (colon, breast, lymph) survival about 2X better with high level vitamin D – meta-analysis July 2014 |
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30 Sep, 2014 |
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Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014 |
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30 Sep, 2014 |
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Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014 |
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12 May, 2014 |
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More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014 |
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08 May, 2014 |
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Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014 |
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08 Apr, 2014 |
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Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013 |
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06 Mar, 2014 |
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Breast Cancer post menopause down 12 percent for every 5 ng of vitamin D – meta-analysis May 2013 |
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28 Oct, 2013 |
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Probably need more than 1000 IU of vitamin D to prevent cancer – meta-analysis Aug 2013 |
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20 Aug, 2013 |
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3.2 percent less Breast Cancer for 2.4 ng more vitamin D – meta-analysis June 2013 |
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08 Jul, 2013 |
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Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011 |
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10 Nov, 2012 |
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Breast cancer association with low vitamin D suggested by Meta-analysis -April 2010 |
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19 Jul, 2012 |
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Colon cancer probability increases with decreased vitamin D – Meta-analysis July 2011 |
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23 Jun, 2012 |
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Vitamin D has a complex relationship with Cancer – meta-analysis July 2011 |
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30 Sep, 2011 |
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Meta-analysis of 3 cancers - 10 ng more vitamin D decrease colorectal by 15 percent– May 2010 |
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31 Aug, 2011 |
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Risk of Prostate Cancer weakly associated with vitamin D - meta-analysis March 2011 |
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11 Aug, 2011 |
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Meta-analysis found vitamin D association with colon but not prostate nor breast cancer May 2010 |
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17 Jan, 2011 |
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Meta-analysis not find low vitamin D years before breast cancer – Aug 2010 |
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10 Sep, 2010 |
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Meta-analysis confirmed that vitamin D and calcium prevents breast cancer – June 2010 |
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30 Aug, 2010 |
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Meta-analysis did not find strong association between vitamin D and breast cancer risk -April 2010 |
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12 May, 2010 |
See also web
- Phrases associated with cancer NYT Jan 2015
“failed tamoxifen”,“platinum resistant” or “refractory” patient, “relapsed” scans which are “clean,” “positive” or “advancing” spells trouble
nodes have been “harvested”; a tumor is “indolent, “minimal or acceptable side effects,” scanxiety,
Nothing about vitamin D
- How cancer cells form tumors by reaching out with ‘cables’ and grabbing cells Jan 2016 (nothing about vitamin D)
"Surprisingly, as little as five percent of cancerous cells are needed to form the tumors, a ratio previously unknown."
“It’s that these cells go out and actively recruit. It’s complicated stuff, and it’s not passive. No one had a clue that there were specialized cells in this process, and that it’s a small number that pulls all the rest in.”
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