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Menstrual pain reduced by Vitamin D (50,000 weekly or 300,000 monthly) – meta-analyses

Vitamin D: 50K weekly or 300K monthly reduced menstural pain - meta-analysis April 2024

Vitamin D Supplementation for Patients with Dysmenorrhoea: A Meta-Analysis with Trial Sequential Analysis of Randomised Controlled Trials
Nutrients 2024, 16(7), 1089; https://doi.org/10.3390/nu16071089

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Vitamin D reduces prostaglandin levels and inflammation, making it a promising treatment option for dysmenorrhoea. However, its effects on pain intensity in different types of dysmenorrhoea remain unclear. We examined whether vitamin D supplementation decreases pain intensity in patients with dysmenorrhoea. The Cochrane Library, Embase, Google Scholar, Medline, and Scopus databases were searched from inception to 30 December 2023. Randomised controlled trials (RCTs) evaluating vitamin D supplementation effects on such patients were included. The primary and secondary outcomes were measured by the changes in pain intensity and rescue analgesic use, respectively. Pooled mean differences and rate ratios were calculated using a random-effect model; trial sequential analysis (TSA) was also performed. Overall, 11 studies involving 687 participants were included. Vitamin D supplementation significantly decreased pain intensity in patients with dysmenorrhoea compared with controls (pooled mean difference, −1.64; 95% confidence interval, −2.27 to −1.00; p < 0.001; CoE, moderate; I2 statistic, 79.43%) and indicated substantial heterogeneity among the included studies. TSA revealed that the current RCTs provide sufficient information. In subgroup analyses, vitamin D supplement reduced primary dysmenorrhoea pain but not secondary dysmenorrhoea pain. In conclusion, although substantial heterogeneity persists, vitamin D supplementation decreased pain intensity in patients with dysmenorrhea, especially in those with primary dysmenorrhoea. Download the PDF from VitaminDWiki

Vitamin D: 50K weekly reduced menstural pain - meta-analysis June 2023

Effect of Vitamin D Supplementation on Primary Dysmenorrhea: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Nutrients. 2023 Jun 21;15(13):2830. doi: 10.3390/nu15132830.
Yi-Chun Chen 1 2, Yi-Fen Chiang 1, Ying-Jiun Lin 1, Ko-Chieh Huang 1, Hsin-Yuan Chen 1, Nadia M Hamdy 3, Tsui-Chin Huang 4, Hsin-Yi Chang 5, Tzong-Ming Shieh 6, Yun-Ju Huang 7, Shih-Min Hsia 1 8 9 10 11

Dysmenorrhea causes pain and inconvenience during menstruation. In addition to medication, natural compounds are widely used to relieve various types of pain. In this study, we aimed to assess the effects of vitamin D (vit. D) supplementation in relieving the symptoms of primary dysmenorrhea. A comprehensive systematic database search of randomized controlled trials (RCTs) was performed. Oral forms of vit. D supplementation were included and compared with a placebo or standard care. The degree of dysmenorrhea pain was measured with a visual analogue scale or numerical rating scale. Outcomes were compared using the standardized mean difference (SMD) and 95% confidence intervals (CIs) in a meta-analysis. RCTs were assessed using the Cochrane risk-of-bias v2 (RoB 2) tool. The meta-analysis included 8 randomized controlled trials involving 695 participants. The results of the quantitative analysis showed a significantly lower degree of pain in the vit. D versus placebo in those with dysmenorrhea (SMD: -1.404, 95% CI: -2.078 to -0.731).
The results of subgroup analysis revealed that pain lessened when the average weekly dose of vit. D was over 50,000 IU, in which dysmenorrhea was relieved regardless of whether vit. D was administered for more or less than 70 days and in any dose interval. The results revealed that vit. D treatment substantially reduced the pain level in the primary dysmenorrhea population. We concluded that vit. D supplementation is an alternative treatment for relieving the pain symptoms of dysmenorrhea.
 Download the PDF from VitaminDWiki

14+ VitaminDWiki pages contain PREMENSTRUAL or PMS in title

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Items found: 14

155 VitaminDWiki pages have 50,000 or 50000 IU in the title

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Items found: 159
Title Modified
Depression cost-effectively reduced by 50,000 IU of Vitamin D monthly (Iranian teens) – July 2023 28 Nov, 2024
Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017 16 Oct, 2024
Migraine Headache duration and intensity reduced by 50,000 IU vitamin D every two week plus probiotics – RCT Oct 2024 14 Oct, 2024
Health can be greatly improved by weekly 50,000 IU of Vitamin D - video and charts Lahore- March 2023 30 Aug, 2024
Health can be greatly improved by weekly 50,000 IU of Vitamin D - video Lahore - March 2023 30 Aug, 2024
High-Doses (50,000 IU weekly, etc.) if at high risk of Vitamin D deficiency - Aug 2024 12 Aug, 2024
50,000 IU of Vitamin D monthly is safe for 1 year, levels still rising – June 2024 13 Jun, 2024
Depression in seniors greatly reduced by Vitamin D (50,000 IU weekly) – meta-analysis June 2023 10 Jun, 2024
Children with ADHD again helped by 50,000 IU weekly Vitamin D – RCT June 2024 18 May, 2024
Sepsis (with mechanical ventilation) treated by 5days of 50,000 IU of Vitamin D – RCT May 2024 06 May, 2024
50,000 IU of Vitamin D - many studies 07 Apr, 2024
50,000 IU of Vitamin D weekly greatly decreased bone loss from prostate cancer therapy - RCT March 2024 24 Mar, 2024
PMS reduced by 50,000 IU every two weeks - RCT Jan 2024 15 Jan, 2024
Following Bariatric surgery, weekly 50,000 IU of standard Vitamin D is not enough – Jan 2024 12 Jan, 2024
Venous ulcers healed 4X faster with weekly 50,000 IU vitamin D – RCT Oct 2012 08 Sep, 2023
Muscle pain in obese women reduced by aerobic exercise plus 50,000 IU Vitamin D - RCT May 2021 27 Aug, 2023
IBS reduced by 50,000 IU of Vitamin D (weekly or bi-weekly) – Meta-analysis July 2023 16 Aug, 2023
Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018 07 Aug, 2023
Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023 22 Jul, 2023
How often might 50,000 IU vitamin D be taken - results of clinical trials 18 Jul, 2023
Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 17 Jul, 2023
Multiple Sclerosis fatigue reduced by weekly Vitamin D (50,000 IU) – June 2023 15 Jul, 2023
Multiple Sclerosis treated equally by UVB and weekly 50,000 IU of Vitamin D – RCT July 2023 18 Jun, 2023
Mild Obstructive Sleep Apnea decreased by 50,000 IU weekly vitamin D – June 2021 20 May, 2023
Chronic tonsillitis virtually eliminated in children by Vitamin D (50,000 IU weekly) – RCT May 2023 20 May, 2023
Breast Cancer trial using 50,000 IU Vitamin D weekly cancelled (no funding) 18 Apr, 2023
Urinary Incontinence reduced by 50,000 IU of vitamin D weekly (details behind paywall) – RCT Feb 2023 24 Feb, 2023
50,000 IU and other high dose vitamin studies 15 Jan, 2023
Can get 50,000 IU Vitamin D anywhere on the globe 21 Dec, 2022
50,000 IU Vitamin D weekly is often recommended 30 Nov, 2022
Diabetes prevented by 50,000 IU vitamin D monthly (Iran) – Jan 2022 03 Nov, 2022
COVID etc. prevented and treated with 50,000 IU Vitamin D capsules - July 2022 22 Jul, 2022
50,000 IU of Vitamin D weekly for 6 months after cardiac failure helps – RCT May 2022 11 Jun, 2022
50,000 IU capsules of Vitamin D can be obtained everywhere - Jan 2022 26 Jan, 2022
Poor odor detection if low Vitamin D, better after 50,000 IU weekly - July 2021 23 Jan, 2022
Resistance training can be aided by Vitamin D, 50,000 IU monthly is not often enough – RCT Dec 2021 11 Jan, 2022
Several smoking problems treated by Vitamin D (bi-weekly, 50,000 IU) - RCT Dec 2021 29 Dec, 2021
50,000 IU Vitamin D weekly was the most popular for Breast Cancer - May 2020 30 Aug, 2021
Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021 19 Aug, 2021
Vitamin D for infections and COVID (50,000 IU weekly for 3 months) – July 2021 02 Aug, 2021
Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019 09 Jul, 2021
Cognitive function of adult women improved in 3 months of 50,000 IU weekly Vitamin D – Jan 2019 09 Jul, 2021
Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021 03 Jun, 2021
Peripheral diabetic neuropathy helped by weekly 50,000 IU vitamin D – Jan 2019 25 May, 2021
Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021 25 Apr, 2021
Reduce COVID-19 risks with 50,000 IU Vitamin D doses 14 Mar, 2021
Stroke patients getting weekly 50,000 IU Vitamin D did better – trial March 2021 12 Mar, 2021
Weekly 50,000 IU was the most succesful way to restore vitamin D levels (football) - Aug 2020 08 Feb, 2021
Endometriosis treated by Vitamin D (50,000 IU bi-weekly) – RCT Jan 2021 30 Jan, 2021
Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT Jan 2021 19 Jan, 2021
Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015 14 Jan, 2021
Take 50,000 IU of Vitamin D weekly before and after COVID-19 vaccination 27 Dec, 2020
Trial: Can 50,000 IU of Vitamin D weekly help with Breast Cancer Chemotherapy - Early 2021 21 Dec, 2020
50,000 IU vitamin D weekly to avoid Osteroporosis after Breast Cancer - May 2020 26 Nov, 2020
BPH (PSA) decreased by Vitamin D (50,000 IU bi-weekly) – RCT Nov 2020 21 Nov, 2020
In Vitro Fertilization clinical trial using 50,000 IU of Vitamin D bi-weekly – Dec 2024 14 Sep, 2020
Newborn Vitamin D - single 50,000 IU is better than daily – RCT Sept 2016 25 Jul, 2020
Weekly 50,000 IU of vitamin D is again found to be good – RCT May 2020 27 May, 2020
Reduce Coronavirus risk with Vitamin D (50,000 IU once a week) 27 Mar, 2020
IBS diarrhea treated by weekly 50,000 IU of Vitamin D – RCT March 2020 25 Mar, 2020
50,000 IU Vitamin D weekly provided enough benefit for combat sport athletes – March 2020 21 Mar, 2020
Response by obese to weekly 50,000 IU of Vitamin D – May 2018 12 Feb, 2020
Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019 18 Jan, 2020
Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023 16 Jan, 2020
Obese lost more weight on diet if added 50,000 IU of vitamin D weekly – many RCTs 25 Dec, 2019
Obese taking 50,000 IU of vitamin D weekly lost more weight (again) – RCT Dec 2019 25 Dec, 2019
General Anxiety Disorder treated by weekly Vitamin D (50,000 IU -Omega-3, Mg also help) – Sept 2019 09 Dec, 2019
Cystic Fibrosis not helped by 50,000 IU of Vitamin D taken twice a month – RCT Feb 2019 01 Nov, 2019
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 19 Oct, 2019
PMS again significantly reduced by 50,000 IU of vitamin D (This time, every two weeks) – RCT Oct 2019 19 Oct, 2019
Depression decreased after vitamin D (50,000 IU weekly to elderly in the case) – RCT Oct 2019 17 Oct, 2019
Long-term neck and back pains greatly reduced by 50,000 IU of Vitamin D – 4 cases – Sept 2019 14 Sep, 2019
Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019 10 Sep, 2019
Athletes helped by weekly 50,000 IU Vitamin D – RCT Aug 2019 10 Aug, 2019
Hay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019 02 Aug, 2019
Urgency Urinary Incontinence in senior black women decreased 40 percent by weekly 50,000 IU vitamin D – RCT Dec 2018 07 Jul, 2019
Treating Vitamin D deficiency in senior women – such as 50,000 IU daily for 15 days then twice a month – Review April 2019 14 Jun, 2019
Grip strength following wrist fracture increased by 50,000 IU Vitamin D monthly – May 2019 09 May, 2019
PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018 23 Mar, 2019
Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019 21 Feb, 2019
Poor Vitamin D binding had 30 percent less response to Vitamin D (50,000 IU weekly) – Feb 2019 04 Feb, 2019
Sleep improved with 50,000 IU Vitamin D every two weeks – RCT Oct 2018 20 Dec, 2018
Depression probably treated by bi-weekly 50,000 IU of vitamin D - RCT 2020 05 Dec, 2018
50,000 IU of vitamin D weekly following cardiac failure helps – RCT 2014 24 Nov, 2018
Attention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018 21 Nov, 2018
Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019 17 Nov, 2018
Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017 02 Nov, 2018
Depression in seniors treated by weekly 50,000 IU of vitamin D – RCT Sept 2018 15 Oct, 2018
50,000 IU of Vitamin D weekly for 9 weeks did not improve CVD – Aug 2018 28 Aug, 2018
Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018 06 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 24 Jun, 2018
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 23 Jun, 2018
Pancreatic Cancer stabilized by a woman taking 50,000 IU of vitamin D daily - 2016 03 Jun, 2018
Pregnancies helped a lot by Vitamin D (injection then 50,000 IU monthly) – RCT May 2018 28 May, 2018
Knee pain and depression reduced by monthly 50,000 IU vitamin D – RCT April 2018 21 Apr, 2018
50,000 IU vitamin D routinely given monthly in New Zealand senior homes since 2011– Dec 2016 07 Apr, 2018
IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016 14 Mar, 2018
HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017 01 Mar, 2018
Cystic Fibrosis got some benefit from 50,000 IU of vitamin D weekly (need gut-friendly form) – Feb 2018 03 Feb, 2018
Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017 18 Nov, 2017
Vitamin D taken daily (4,000 IU) vs weekly (50,000 IU) – RCT 2019 23 Oct, 2017
Vitamin D supplementation for newborns – 400 IU daily vs 50,000 IU dose – RCT Sept 2016 21 Oct, 2017
Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017 01 Sep, 2017
Sleep quality improved with 50,000 IU of vitamin D every two weeks – RCT May 2017 23 Aug, 2017
Preeclampsia reoccurred half as often if get 50,000 IU of Vitamin D every two weeks – Aug 2017 22 Aug, 2017
Vitamin D supplementation guidelines (adults – 50,000 IU per week) – Feb 2017 21 Aug, 2017
Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017 27 Jul, 2017
Canadian grant funding lost for prescribing 50,000 IU of vitamin D – July 2017 23 Jul, 2017
Cervical lesions (precancerous, identified by pap smear) treated by bi-weekly 50,000 IU of vitamin D – RCT Feb 2017 22 Jul, 2017
Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014 20 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
Chinese women in tropics needed 50,000 IU of Vitamin D monthly to keep above 30 ng – RCT May 2017 14 Jul, 2017
50,000 IU of vitamin D every two weeks – Jordan conclusion - RCT July 2017 08 Jul, 2017
Fertility marker (Anti-Müllerian Hormone) improved in a week by a single dose to 50,000 IU of vitamin D – RCT July 2017 08 Jul, 2017
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – Nov 2016 27 Jun, 2017
Many benefits of 50,000 IU vitamin D every two weeks (methadone treatment) – RCT June 2017 21 Jun, 2017
Don’t take a PRESCRIPTION of 50,000 IU of vitamin D – June 2017 05 Jun, 2017
Vitamin D – 50,000 IU monthly is enough if near the equator and have normal weight – May 2017 25 Apr, 2017
50,000 IU vitamin D weekly is safe and effective for Primary Hyperparathyroidism – Jan 2013 23 Jan, 2017
Pulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016 16 Jan, 2017
Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015 24 Nov, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015 06 Aug, 2016
Free Vitamin D in New Zealand to prevent falls in nursing homes (50,000 IU monthly) – June 2016 30 Jul, 2016
50,000 IU vitamin D daily in ICU greatly reduces number and cost of heart attacks – Nov 2015 24 Jun, 2016
Nursing home residents need Vitamin D 4,000 IU daily or 50,000 IU weekly – Jan 2016 25 May, 2016
IBS quality of life improved by vitamin D (50,000 IU weekly) – RCT May 2016 17 May, 2016
Prediabetics not helped by 50,000 IU of vitamin D weekly and Calcium– Jan 2013 03 Apr, 2016
New Zealand – new 50,000 IU vitamin D capsule has soy which can cause allergic reactions – March 2016 09 Mar, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 08 Mar, 2016
Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015 22 Oct, 2015
Vitamin D loading dose then weekly 50,000 IU not help (COPD) if very deficient – Oct 2015 16 Oct, 2015
Preeclampsia reduced by Vitamin D (50,000 IU bi-weekly) and Calcium – Oct 2015 15 Oct, 2015
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Vitamin D more than 40 ng: 1300 IU 50% chance: 5,000 IU 80% chance - Aug 2014 13 Sep, 2015
Vitamin D levels of HIV and non HIV equally restored with 50,000 IU twice a week - July 2015 24 Jul, 2015
Diabetes not treated by MONTHLY 50,000 IU vitamin D (which is not quite enough) – May 2015 12 Jul, 2015
Diabetes RCT we expect to fail just 50,000 IU monthly - July 2014 12 Jul, 2015
No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015 21 Jun, 2015
Near the end of pregnancy 50,000 IU vitamin D weekly was great – RCT April 2013 08 Jun, 2015
Pregnant mothers in Quatar needed more than weekly 50,000 IU Vitamin D – Nov 2013 28 Mar, 2015
Peripheral Neuropathy in type II Diabetes reduced a bit by 50,000 IU weekly of vitamin D – RCT Feb 2015 28 Mar, 2015
Lupus not treated by monthly 50,000 IU vitamin D (no surprise) – RCT April 2015 23 Mar, 2015
50,000 IU Vitamin D one time after birth helped – RCT Jan 2015 14 Jan, 2015
50,000 IU monthly safe to take without any vitamin D testing – RCT Dec 2013 22 Dec, 2014
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 22 Nov, 2014
Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014 24 Oct, 2014
Diabetes treated by 50,000 IU of vitamin D weekly with 1 g Calcium daily – RCT July 2014 14 Sep, 2014
7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012 20 Aug, 2014
Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014 03 Aug, 2014
Vitamin D repaired nerve in rat (50,000 IU daily dose equivalent for human) – June 2013 28 Jun, 2014
Optic neuritis progession into Multiple Sclerosis reduced 68 percent by 50,000 IU of vitamin D weekly 08 May, 2014
COPD helped by weekly 50,000 IU Vitamin D – Aug 2013 03 May, 2014
7100 IU vitamin D (50,000 weekly) significantly reduced fibromyalgia – 2009 20 Jan, 2014
Need to adjust cofactors if take 50,000 IU of vitamin D weekly – Nov 2013 12 Jan, 2014
50,000 IU of vitamin D monthly in winter gets most above 20 ng – RCT Nov 2013 21 Dec, 2013
50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013 13 Nov, 2013
50,000 IU vitamin D 1-3 times per week helped obese patients in rehab. – May 2013 01 Aug, 2013
50,000 IU vitamin D suggested to prevent osteoporosis (weekly then monthly)– April 2019 No value for &#039;modification_date_major&#039;
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Menstrual pain reduced by Vitamin D (50,000 weekly or 300,000 monthly) – meta-analyses        
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21087 Dys pain score.png admin 11 Apr, 2024 64.22 Kb 60
21086 dysmenorrhea table.png admin 11 Apr, 2024 80.12 Kb 47
21085 Dysmenorrhoea Meta-Analysis_CompressPdf.pdf admin 11 Apr, 2024 367.29 Kb 34
19804 Dysmenorrhea meta_CompressPdf.pdf admin 15 Jul, 2023 363.88 Kb 83