Psychotic problems associated with low vitamin D – review Sept 2021

The association between vitamin D and symptom domains in psychotic disorders: A systematic review

Schizophr Res . 2021 Sep 8;237:79-92. doi: 10.1016/j.schres.2021.08.001 - PDF is behind a paywall
Jonathan Tsiglopoulos 1, Nicholas Pearson 1, Nathan Mifsud 1, Kelly Allott 1, Brian O'Donoghue 2

VitaminDWiki

NOTE: This review probably ignores
dose size,
dose duration.
dose type,
any use of Omega-3,
initial vitamin D level in RCTs
low vitamin D as child or in utero, etc.

Intervention of Vitamin D for Depression

Meta-analyses of Depression

Meta-analyses of Omega-3 and Depression

Depression category listing has 268 items along with related searches

Depression summary

Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
Depression substantially reduced by Vitamin D, Omega-3, Magnesium, etc – many studies
Depression 1.6 X more likely if low Vitamin D, taking Vitamin D reduces depression – umbrella of meta-analyses – Jan 2023
Depression: Low vitamin D in the strongest of 11 risk factors – Jan 2023
Yet another study confirms Depression is treated by weekly Vitamin D (50,000 IU)– RCT Dec 2019
Depression treated by Omega-3 (again) – meta-analysis Aug 2019
Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
Omega-3, Magnesium, and St. Johns' Wort also decrease depression
- Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
- Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
There are 268 items in the Depression category in VitaminDWiki

Some recent publications

Anxiety studies include

14+ VitaminDWiki pages with ANXIETY in title
This list is automatically updated

Items found: 17

Title		Modified
Long-COVID fatigue, anxiety, and cognition treated by 60,000 IU of vitamin D weekly – RCT July 2024		29 Jul, 2024
New anxiety after age 50 predicts 2.1 X increased risk of Parkinson’s – July 2024		06 Jul, 2024
International Adolescent Anxiety and suicide rates - GBD April 2024		07 Apr, 2024
Half as much anxiety and sleep problems if get lots of vitamin D from food (excluded getting D from supplements) – Feb 2024		23 Feb, 2024
Anxiety, Vitamin D, Omega-3 - many studies		23 Feb, 2024
Low Vitamin D is associated with risk of Depression 5X, Stress 4.8 X, and Anxiety 3.9 X (Saudi Arabia college students) – July 2023		29 Jul, 2023
Parkinson’s – Vitamin D, bone density, insomnia, falls, poor sleep, anxiety – March 2019		10 May, 2023
Anxiety and Depression decreased in senior prediabetics with weekly 25,000 IU of Vitamin D – RCT Sept 2022		22 Dec, 2022
Depression and Anxiety treatment with Vitamin D - probable molecular pathways - June 2022		21 Dec, 2022
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022		07 Oct, 2022
Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022		29 May, 2022
General Anxiety Disorder treated by weekly Vitamin D (50,000 IU -Omega-3, Mg also help) – Sept 2019		09 Dec, 2019
Omega-3 reduces Depression. Anxiety, Stress, PTSD, etc. – Aug 2018		02 Sep, 2019
Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018		10 Nov, 2018
Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018		19 Sep, 2018
Why is teen anxiety increasing so much (no mention of Magnesium, Vitamin D nor Omega-3) – Oct 2017		11 Oct, 2017
Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014		11 Feb, 2015

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

391 items in Cognition category

Studies in both categories of Cognition and:
Cardiovascular (8 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (52 studies), Intervention (20 studies), Meta-analyses (22 studies), Depression (24 studies), Parkinson's (24 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

Overview Schizophrenia and Vitamin D contains the following summary

14 reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored

Background: Vitamin D deficiency is prevalent among people with psychosis and may play a role in the aetiology of psychotic disorders. However, its impact on clinical symptom severity has not been independently reviewed.

Methods: We conducted a systematic search of randomized trials and observational studies that assessed the relationship between vitamin D and symptom domains (positive and negative psychotic symptoms, total and general psychopathology, cognitive and depressive) in people with a psychotic disorder.

Results: 1040 articles were identified, of which 29 were eligible for inclusion: 26 observational studies and 3 randomized trials. Five studies included people with First-Episode Psychosis (FEP) and 24 included people with enduring psychosis. Most observational studies found that vitamin D was

inversely associated with negative symptoms (57%; 13/23),
positively associated with cognitive performance (63%; 5/8), and
bore no association with positive symptoms (68%; 15/22),
- total psychopathology (64%; 7/11),
- general psychopathology (57%; 4/7) or
- depressive symptoms (64%; 9/14).

Randomized controlled trials indicated that vitamin D supplementation

improved cognitive performance (100%; 1/1) and, in some cases,

reduced

total psychopathology (50%; 1/2),
general psychopathology (50%; 1/2) and
negative symptoms (30%; 1/3), but had
no effect on positive (100%; 3/3) or depressive (100%; 3/3) symptoms.

Some positive associations were attenuated when controlled for potential confounders.

Conclusion: Low vitamin D was found to be inversely associated with more severe clinical symptoms in some, but not all symptom domains in people with psychosis. These preliminary findings warrant further exploration, particularly in regard to cognitive performance and negative symptoms.