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Vitamin D response independent of dosing interval – meta-analysis July 2023


Efficacy of intermittent versus daily vitamin D supplementation on improving circulating 25(OH)D concentration: A Bayesian network meta-analysis of randomized controlled trials

Front. Nutr.Sec. Nutritional Epidemiology Volume 10 - 2023 | doi: 10.3389/fnut.2023.1168115   PDF not available initially
Hui Liu1, 2* Haibo Zhou1 Zhicheng Peng1 Haoyue Cheng1 Peihan Chi1 Xing Xin1 Wenliang Luo1 Shuting Si1 Minjia Mo1 Danqing Chen1 Yunxian Yu1*
1 Zhejiang University, China
2 Sir Run run shaw hospital, China

NMOL achieved (reminder, need >2 months to get full response)
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Background: Vitamin D deficiency is a widespread issue globally, resulting in increased use of vitamin D supplements. However, it is unclear whether intermittent (weekly or monthly) vitamin D supplementation is as effective as daily supplementation in improving circulating 25-hydroxyvitamin D [25(OH)D] levels.

Methods: Three databases including Medline, EMBASE, and Cochrane Library were systematically searched up to Nov 10, 2020. Risk of bias was evaluated according to Cochrane Collaboration's tool for rating methodological quality assessment. Direct and indirect comparisons between interventions and controls were performed by a Bayesian network meta-analysis (NMA), where mean difference (MD) and its 95% confidence interval (CI) was used to indicate the efficacy.

Results: This NMA analysis included 116 RCTs with a total of 11,376 participants. Generally, we observed 25(OH)D concentrations were significantly elevated regardless of vitamin D supplementation frequency. Although the findings of SUCRA indicated that daily vitamin D supplementation had a higher rank value than intermittent supplementation when the supplement dosage was similar, no statistically significant pooled mean differences of 25(OH)D concentration were noted between daily supplementation group and intermittent supplementation group.
Additionally, weekly supplementation with a total of 600,000 IU vitamin D supplementation during three months had the best efficacy in elevating 25(OH)D concentration (pooled MD=63 nmol/L, 95%CI: 49-77). To achieve optimal 25(OH)D concentration (>75 nmol/L), we recommended 60,000 IU vitamin D supplementation monthly (~2000 IU/day).

Conclusion: To sum up, the efficacy of intermittent vitamin D supplementation was similar to daily supplementation. Coupled with its convenience, frequency and dosage of intermittent vitamin D supplements were recommended to reach optimal 25(OH)D 4 level.
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VitaminDWiki – Better than Daily contains
33 items in BETTER THAN DAILY category

Non-daily (Bolus) is better:

  1. Better compliance for everyone
    • Fewer opportunities to forget.
    • If happen to forget, just take the dose many days later
    • Fewer times to have to take a pill - for those who dislike doing so
  2. Non-daily gets more vitamin D to the cells for the ~20% who have a poor Vitamin D Receptor

VitaminDWiki – Intervention - non daily category has 48 items


Attached files

ID Name Comment Uploaded Size Downloads
20363 Dosing daily, weekly monthly.png admin 13 Nov, 2023 83.82 Kb 76
20362 Dosing Meta.pdf admin 13 Nov, 2023 967.88 Kb 2019